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Compartmentalized dendritic plasticity and input feature storage in neurons

Nature volume 452, pages 436–441 (2008)Cite this article

Abstract

Although information storage in the central nervous system is thought to be primarily mediated by various forms of synaptic plasticity, other mechanisms, such as modifications in membrane excitability, are available. Local dendritic spikes are nonlinear voltage events that are initiated within dendritic branches by spatially clustered and temporally synchronous synaptic input. That local spikes selectively respond only to appropriately correlated input allows them to function as input feature detectors and potentially as powerful information storage mechanisms. However, it is currently unknown whether any effective form of local dendritic spike plasticity exists. Here we show that the coupling between local dendritic spikes and the soma of rat hippocampal CA1 pyramidal neurons can be modified in a branch-specific manner through an N-methyl-d-aspartate receptor (NMDAR)-dependent regulation of dendritic Kv4.2 potassium channels. These data suggest that compartmentalized changes in branch excitability could store multiple complex features of synaptic input, such as their spatio-temporal correlation. We propose that this ‘branch strength potentiation’ represents a previously unknown form of information storage that is distinct from that produced by changes in synaptic efficacy both at the mechanistic level and in the type of information stored.

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Figure 1: Two populations of dendritic spike strengths.
Figure 2: Relationship of dendritic morphology and branch strength.
Figure 3: Branch strength potentiation.
Figure 4: Specificity and associativity of branch strength potentiation.
Figure 5: BSP is mediated by reduced A-type K + channel function.

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Acknowledgements

We thank G. Buzsaki, D. Johnston, J. Lisman and Z. Nusser for their comments on a previous version of the manuscript. We thank D. Johnston for the Kv.4.2 mice and B. K. Andrasfalvy for valuable discussions and help with experiments using Kv4.2 mice.

Author Contributions A.L. and J.K.M. performed and analysed the experiments, A.L., J.K.M. and J.C.M. designed the experiments, and all authors contributed to the manuscript preparation.

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  1. Attila Losonczy and Judit K. Makara: These authors contributed equally to this work.

Authors and Affiliations

  1. Howard Hughes Medical Institute, Janelia Farm Research Campus, 19700 Helix Dr Ashburn, Virginia 20147, USA,

    Attila Losonczy, Judit K. Makara & Jeffrey C. Magee

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  1. Attila Losonczy
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  2. Judit K. Makara
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Correspondence to Attila Losonczy or Judit K. Makara.

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Losonczy, A., Makara, J. & Magee, J. Compartmentalized dendritic plasticity and input feature storage in neurons. Nature 452, 436–441 (2008). https://doi.org/10.1038/nature06725

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