Notch signals control the fate of immature progenitor cells in the intestine

1. Artavanis-Tsakonas, S., Rand, M. D. & Lake, R. J. Notch signaling: cell fate control and signal integration in development. Science 284, 770–776 (1999)

   Article  ADS  CAS  Google Scholar 

2. Greenwald, I. LIN-12/Notch signaling: lessons from worms and flies. Genes Dev. 12, 1751–1762 (1998)

   Article  CAS  Google Scholar 

3. Kimble, J. & Simpson, P. The LIN-12/Notch signaling pathway and its regulation. Annu. Rev. Cell Dev. Biol. 13, 333–361 (1997)

   Article  CAS  Google Scholar 

4. Weinmaster, G. The ins and outs of notch signaling. Mol. Cell. Neurosci. 9, 91–102 (1997)

   Article  CAS  Google Scholar 

5. Shen, Q. et al. Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells. Science 304, 1338–1340 (2004)

   Article  ADS  CAS  Google Scholar 

6. Varnum-Finney, B. et al. Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling. Nature Med. 6, 1278–1281 (2000)

   Article  CAS  Google Scholar 

7. Jensen, J. et al. Control of endodermal endocrine development by Hes-1. Nature Genet. 24, 36–44 (2000)

   Article  ADS  CAS  Google Scholar 

8. Yang, Q., Bermingham, N. A., Finegold, M. J. & Zoghbi, H. Y. Requirement of Math1 for secretory cell lineage commitment in the mouse intestine. Science 294, 2155–2158 (2001)

   Article  ADS  CAS  Google Scholar 

9. Jenny, M. et al. Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium. EMBO J. 21, 6338–6347 (2002)

   Article  CAS  Google Scholar 

10. Pinto, D., Robine, S., Jaisser, F., El Marjou, F. E. & Louvard, D. Regulatory sequences of the mouse villin gene that efficiently drive transgenic expression in immature and differentiated epithelial cells of small and large intestines. J. Biol. Chem. 274, 6476–6482 (1999)

    Article  CAS  Google Scholar 

11. Madison, B. B. et al. Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine. J. Biol. Chem. 277, 33275–33283 (2002)

    Article  CAS  Google Scholar 

12. Maunoury, R. et al. Developmental regulation of villin gene expression in the epithelial cell lineages of mouse digestive and urogenital tracts. Development 115, 717–728 (1992)

    CAS  Google Scholar 

13. Maunoury, R. et al. Villin expression in the visceral endoderm and in the gut anlage during early mouse embryogenesis. EMBO J. 7, 3321–3329 (1988)

    Article  CAS  Google Scholar 

14. el Marjou, F. et al. Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis 39, 186–193 (2004)

    Article  CAS  Google Scholar 

15. Murtaugh, L. C., Stanger, B. Z., Kwan, K. M. & Melton, D. A. Notch signaling controls multiple steps of pancreatic differentiation. Proc. Natl Acad. Sci. USA 100, 14920–14925 (2003)

    Article  ADS  CAS  Google Scholar 

16. Hofer, D. & Drenckhahn, D. Cytoskeletal markers allowing discrimination between brush cells and other epithelial cells of the gut including enteroendocrine cells. Histochem. Cell Biol. 105, 405–412 (1996)

    Article  CAS  Google Scholar 

17. Bry, L. et al. Paneth cell differentiation in the developing intestine of normal and transgenic mice. Proc. Natl Acad. Sci. USA 91, 10335–10339 (1994)

    Article  ADS  CAS  Google Scholar 

18. Ohtsuka, T. et al. Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation. EMBO J. 18, 2196–2207 (1999)

    Article  CAS  Google Scholar 

19. Zine, A. & de Ribaupierre, F. Notch/Notch ligands and Math1 expression patterns in the organ of Corti of wild-type and Hes1 and Hes5 mutant mice. Hear. Res. 170, 22–31 (2002)

    Article  CAS  Google Scholar 

20. Lee, J. C. et al. Regulation of the pancreatic pro-endocrine gene neurogenin3. Diabetes 50, 928–936 (2001)

    Article  CAS  Google Scholar 

21. Go, M. J., Eastman, D. S. & Artavanis-Tsakonas, S. Cell proliferation control by Notch signaling in Drosophila development. Development 125, 2031–2040 (1998)

    CAS  Google Scholar 

22. Capobianco, A. J., Zagouras, P., Blaumueller, C. M., Artavanis-Tsakonas, S. & Bishop, J. M. Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2. Mol. Cell. Biol. 17, 6265–6273 (1997)

    Article  CAS  Google Scholar 

23. Gerdes, J., Schwab, U., Lemke, H. & Stein, H. Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. Int. J. Cancer 31, 13–20 (1983)

    Article  CAS  Google Scholar 

24. Fath, K. R., Obenauf, S. D. & Burgess, D. R. Cytoskeletal protein and mRNA accumulation during brush border formation in adult chicken enterocytes. Development 109, 449–459 (1990)

    CAS  Google Scholar 

25. Louvard, D., Kedinger, M. & Hauri, H. P. The differentiating intestinal epithelial cell: establishment and maintenance of functions through interactions between cellular structures. Annu. Rev. Cell Biol. 8, 157–195 (1992)

    Article  CAS  Google Scholar 

26. van Es, J. et al. Notch pathway/γ-secretase inhibition turns proliferative cells in intestinal crypts and neoplasia into Goblet cells. Nature doi:10.1038/nature03659 (this issue)

27. Crosnier, C. et al. Delta-Notch signalling controls commitment to a secretory fate in the zebrafish intestine. Development 132, 1093–1094 (2005)

    Article  CAS  Google Scholar 

28. Korinek, V. et al. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nature Genet. 19, 379–383 (1998)

    Article  CAS  Google Scholar 

29. Galceran, J., Sustmann, C., Hsu, S. C., Folberth, S. & Grosschedl, R. LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis. Genes Dev. 18, 2718–2723 (2004)

    Article  CAS  Google Scholar 

30. Sancho, E., Batlle, E. & Clevers, H. Live and let die in the intestinal epithelium. Curr. Opin. Cell Biol. 15, 763–770 (2003)

    Article  CAS  Google Scholar 

31. Ito, T. et al. Basic helix–loop–helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium. Development 127, 3913–3921 (2000)

    CAS  Google Scholar 

Download references