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  • Review Article
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Memory enhancement: the search for mechanism-based drugs

Nature Neuroscience volume 5, pages 1035–1038 (2002)Cite this article

Abstract

Rapid progress has been made in understanding the synaptic changes required for memory encoding. Several companies are now attempting to use information about the induction and consolidation phases of this process to build memory-enhancing drugs. These efforts have produced novel compounds that improve retention scores across a broad range of tests and species. Initial clinical results are encouraging. Issues now arise about appropriate applications of candidate drugs and optimal cellular targets for future development.

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Figure 1: Targets for the development of memory-enhancing drugs.
Figure 2: Positive modulators of AMPA receptors.
Figure 3: Effects of a positive modulator on the recall of nonsense syllables by aged subjects.

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Authors and Affiliations

  1. Department of Psychiatry, University of California, Irvine, 92612, California, USA

    Gary Lynch

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  1. Gary Lynch
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Lynch, G. Memory enhancement: the search for mechanism-based drugs. Nat Neurosci 5 (Suppl 11), 1035–1038 (2002). https://doi.org/10.1038/nn935

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  • DOI: https://doi.org/10.1038/nn935

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