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Rational design of potent sialidase-based inhibitors of influenza virus replication

Nature volume 363, pages 418–423 (1993)Cite this article

An Erratum to this article was published on 28 October 1993

Abstract

Two potent inhibitors based on the crystal structure of influenza virus sialidase have been designed. These compounds are effective inhibitors not only of the enzyme, but also of the virus in cell culture and in animal models. The results provide an example of the power of rational, computer-assisted drug design, as well as indicating significant progress in the development of a new therapeutic or prophylactic treatment for influenza infection.

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Author notes

  1. Hume F. White

    Present address: CSIRO Division of Wool Technology, Clayton, Victoria, Australia

Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, Victorian College of Pharmacy, Monash University, 381 Royal Parade, Parkville, Victoria, 3052, Australia

    Mark von Itzstein, Wen-Yang Wu, Gaik B. Kok, Michael S. Pegg, Jeffrey C. Dyason, Betty Jin, Tho Van Phan, Mark L. Smythe, Hume F. White & Stuart W. Oliver

  2. CSIRO Division of Biomolecular Engineering, Parkville, Victoria, 3052, Australia

    Peter M. Colman & Joseph N. Varghese

  3. Glaxo Group Research Ltd, Greenford, Middlesex, UB6 OHE, UK

    D. Michael Ryan, Jacqueline M. Woods, Richard C. Bethell, Vanessa J. Hotham, Janet M. Cameron & Charles R. Penn

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  1. Mark von Itzstein
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von Itzstein, M., Wu, WY., Kok, G. et al. Rational design of potent sialidase-based inhibitors of influenza virus replication. Nature 363, 418–423 (1993). https://doi.org/10.1038/363418a0

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