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Macrophage-induced angiogenesis is mediated by tumour necrosis factor-α

Nature volume 329, pages 630–632 (1987)Cite this article

Abstract

Macrophages are important in the induction of new blood vessel growth during wound repair, inflammation and tumour growth1–4. We show here that tumour necrosis factor-α (TNF-α), a secretory product of activated macrophages that is believed to mediate tumour cytotoxicity5–9, is a potent inducer of new blood vessel growth (angiogenesis). In vivo, TNF-α induces capillary blood vessel formation in the rat cornea and the developing chick chorioallantoic membrane at very low doses. In vitro, TNF-α stimulates chemotaxis of bovine adrenal capillary endothelial cells and induces cultures of these cells grown on type-1 collagen gels to form capillary-tube-like structures. The angiogenic activity produced by activated murine peritoneal macrophages is completely neutralized by a polyclonal antibody to TNF-α, suggesting immunological features are common to TNF-α and the protein responsible for macrophage-derived angiogenic activity. In inflammation and wound repair, TNF-α could augment repair by stimulating new blood vessel growth; in tumours, TNF-α might both stimulate tumour development by promoting vessel growth and participate in tumour destruction by direct cytotoxicity10–12.

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Authors and Affiliations

  1. Department of Oral Biology, Northwestern University Dental School, 303 E. Chicago Avenue, Chicago, Illinois, 60611, USA

    S. Joseph Leibovich, David M. Wiseman, Vera Shively & Nureddin Nuseir

  2. Department of Pathology, Northwestern University Dental School, 303 E. Chicago Avenue, Chicago, Illinois, 60611, USA

    Peter J. Polverini

  3. Department of Pharmacological Sciences, Genentech Inc., South San Francisco, California, 94080, USA

    H. Michael Shepard

Authors
  1. S. Joseph Leibovich
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  2. Peter J. Polverini
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  3. H. Michael Shepard
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  4. David M. Wiseman
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  5. Vera Shively
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  6. Nureddin Nuseir
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Leibovich, S., Polverini, P., Shepard, H. et al. Macrophage-induced angiogenesis is mediated by tumour necrosis factor-α. Nature 329, 630–632 (1987). https://doi.org/10.1038/329630a0

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