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Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein

Nature volume 312, pages 711–716 (1984)Cite this article

Abstract

Exposure of quiescent mouse fibroblasts to platelet-derived growth factor induces mRNA from the c-fos proto-oncogene within 10 min followed by synthesis of nuclear c-fos proteins. These are amongst the earliest described nuclear events that follow a mitogenic stimulus.

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Authors and Affiliations

  1. Molecular Biology and Virology Laboratory, The Salk Institute, PO Box 85800, San Diego, California, 92138, USA

    Wiebe Kruijer, Jonathan A. Cooper, Tony Hunter & Inder M. Verma

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  1. Wiebe Kruijer
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  2. Jonathan A. Cooper
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  3. Tony Hunter
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  4. Inder M. Verma
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Kruijer, W., Cooper, J., Hunter, T. et al. Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein. Nature 312, 711–716 (1984). https://doi.org/10.1038/312711a0

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