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An Analytical Model for the ‘Large, Fluctuating Synaptic Conductance State’ Typical of Neocortical Neurons In Vivo

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Abstract

A model of in vivo-like neocortical activity is studied analytically in relation to experimental data and other models in order to understand the essential mechanisms underlying such activity. The model consists of a network of sparsely connected excitatory and inhibitory integrate-and-fire (IF) neurons with conductance-based synapses. It is shown that the model produces values for five quantities characterizing in vivo activity that are in agreement with both experimental ranges and a computer-simulated Hodgkin-Huxley model adapted from the literature (Destexhe et al. (2001) Neurosci. 107(1): 13–24). The analytical model builds on a study by Brunel (2000) (J. Comput. Neurosci. 8: 183–208), which used IF neurons with current-based synapses, and therefore does not account for the full range of experimental data. The present results suggest that the essential mechanism required to explain a range of data on in vivo neocortical activity is the conductance-based synapse and that the particular model of spike initiation used is not crucial. Thus the IF model with conductance-based synapses may provide a basis for the analytical study of the ‘large, fluctuating synaptic conductance state’ typical of neocortical neurons in vivo.

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Authors and Affiliations

  1. The Bionic Ear Institute, 384-388 Albert St, East Melbourne, Vic, 3002, Australia

    Hamish Meffin, Anthony N. Burkitt & David B. Grayden

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  1. Hamish Meffin
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  2. Anthony N. Burkitt
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  3. David B. Grayden
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Meffin, H., Burkitt, A.N. & Grayden, D.B. An Analytical Model for the ‘Large, Fluctuating Synaptic Conductance State’ Typical of Neocortical Neurons In Vivo . J Comput Neurosci 16, 159–175 (2004). https://doi.org/10.1023/B:JCNS.0000014108.03012.81

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