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Flavonol and flavone intake and the risk of cancer in male smokers (Finland)

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Abstract

Objective: To study the associations between the intake of flavonols and flavones and the risk of cancer.

Methods: The study cohort consisted of 27,110 male smokers, aged 50–69 years, without history of cancer. They were participants of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study in Finland. The men completed a validated dietary questionnaire at baseline. Incident cases of cancers were identified through national registers. During an average 6.1-year follow-up, 791 lung cancers, 226 prostate cancers, 156 urothelial cancers, 133 colorectal cancers, 111 stomach cancers, and 92 renal cell cancers were diagnosed.

Results: Intake of flavonols and flavones was inversely associated with the risk of lung cancer; multivariate relative risk in the highest vs. the lowest quartile 0.56, 95% confidence interval 0.45–0.69, p for trend 0.0001. The risk was similar in all histological types of lung cancer. No association was found between flavonol and flavone intake and the risk of other cancers.

Conclusions: Intake of flavonols and flavones seemed to be inversely associated with the risk of lung cancer, but not with that of other cancers.

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References

  1. Agullo G, Gamet-Payrastre L, Fernandez Y, Anciaux N, Demigné C, Rémésy C (1996) Comparative effects of flavonoids on the growth, viability and metabolism of a colonic adenocarcinoma cell line (HT29 cells). Cancer Lett 105: 61–70.

    PubMed  Google Scholar 

  2. Kuo SM (1996) Antiproliferative potency of structurally distinct dietary flavonoids on human colon cancer cells. Cancer Lett 110: 41–48.

    PubMed  Google Scholar 

  3. Zeng LH, Wu J, Fung B, Tong JH, Mickle D, Wu TW (1997) Comparative protection against oxyradicals by three flavonoids on cultured endothelial cells. Biochem Cell Biol 75: 717–720.

    PubMed  Google Scholar 

  4. Fotsis T, Pepper MS, Aktas E, et al. (1997) Flavonoids, dietary-derived inhibitors of cell proliferation and in vitro angiogenesis. Cancer Res 57: 2916–2921.

    PubMed  Google Scholar 

  5. Kawaii S, Tomono Y, Katase E, Ogava K, Yano M (1999) Antiproliferative activity of flavonoids on several cancer cell lines. Biosci Biotechnol Biochem 63: 896–899.

    PubMed  Google Scholar 

  6. Kawaii S, Tomono Y, Katase E, Ogawa K, Yano M (1999) Effect of citrus flavonoids on HL-60 cell differentiation. Anticancer Res 19: 1261–1270.

    PubMed  Google Scholar 

  7. Verma AK, Johnson JA, Gould MN, Tanner MA (1988) Inhibition of 7,12-dimethylbenz(a)anthracene-and N-nitrosomethylurea-induced rat mammary cancer by dietary flavonol quercetin. Cancer Res 48: 5754–5758.

    PubMed  Google Scholar 

  8. Deschener EE, Ruperto J, Wong G, Newmark HL (1991) Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia. Carcinogenesis 12: 1193–1196.

    PubMed  Google Scholar 

  9. Makita H, Tanaka T, Fujitsuka H, et al. (1996) Chemoprevention of 4-nitroquinoline 1-oxide-induced rat oral carcinogenesis by the dietary flavonoids chalcone, 2-hydroxychalcone, and quercetin. Cancer Res 56: 4904–4909.

    PubMed  Google Scholar 

  10. Khanduja KL, Gandhi RK, Pathania V, Syal N (1999) Prevention of N-nitrosodiethylamine-induced lung tumorigenesis by ellagic acid and quercetin in mice. Food Chem Toxicol 37: 313–318.

    PubMed  Google Scholar 

  11. Kang ZC, Tsai SJ, Lee H (1999) Quercetin inhibits benzo[a]pyrene-induced DNA adducts in human Hep G2 cells by altering cytochrome P-450 1A1 gene expression. Nutr Cancer 35: 175–179.

    PubMed  Google Scholar 

  12. Kandaswami C, Middleton E (1994) Free radical scavenging and antioxidant activity of plant flavonoids. Adv Exp Med Biol 366: 351–376.

    PubMed  Google Scholar 

  13. Gamet-Payrastre L, Manenti S, Gratacap MP, Tulliez J, Chap H, Payrastre B (1999) Flavonoids and the inhibition of PKC and PI-kinase. Gen Pharmacol 32: 279–286.

    PubMed  Google Scholar 

  14. Csokay B, Prajda N, Weber G, Olah E (1997) Molecular mechanisms in the antiproliferative action of quercetin. Life Sci 60: 2157–2163.

    PubMed  Google Scholar 

  15. Wei YQ, Kariya Y, Fukata H, Teshigawara K, Uchida A (1994) Induction of apoptosis by quercetin: involvement of heat shock protein. Cancer Res 54: 4952–4957.

    PubMed  Google Scholar 

  16. Sahu SC, Gray GC (1996) Pro-oxidant activity of flavonoids: effects of glutathione and glutathione S-transferase in isolated rat liver nuclei. Cancer Lett 104: 193–196.

    PubMed  Google Scholar 

  17. Galati G, Chan T, Wu B, O'Brien PJ (1999) Glutathione-dependent generation of reactive oxygen species by the peroxidase-catalyzed redox cycling of flavonoids. Chem Res Toxicol 12: 521–525.

    PubMed  Google Scholar 

  18. ElAttar TMA, Virji AS (1993) Modulating effect of resveratrol and quercetin on oral cancer cell growth and proliferation. Anticancer Drugs 10: 187–193.

    Google Scholar 

  19. Rowland I (1993) Dietary modification of the activity of food mutagens. Mutagenesis 8: 476.

    Google Scholar 

  20. Hertog MGL, Feskens EJM, Hollman PCH, Katan MB, Kromhout D (1994) Dietary flavonoids and cancer risk in the Zutphen Elderly Study. Nutr Cancer 22: 175–184.

    PubMed  Google Scholar 

  21. Hertog MGL, Sweetnam PM, Fehily AM, Elwood PC, Kromhout D (1997) Antioxidant flavonols and ischemic heart disease in a Welsh population of men — the Caerphilly Study. Am J Clin Nutr 65: 1489–1494.

    PubMed  Google Scholar 

  22. Knekt P, Järvinen R, Seppänen R, et al. (1997) Dietary flavonoids and the risk of lung cancer and other malignant neoplasms. Am J Epidemiol 146: 223–230.

    PubMed  Google Scholar 

  23. Garcia-Closas R, Agudo A, Gonzalez CA, Riboli E (1998) Intake of specific carotenoids and flavonoids and the risk of lung cancer in women in Barcelona, Spain. Nutr Cancer 32: 154–158.

    PubMed  Google Scholar 

  24. Garcia R, Gonzalez CA, Agudo A, Riboli E (1999) High intake of specific carotenoids and flavonoids does not reduce the risk of bladder cancer. Nutr Cancer 35: 212–214.

    PubMed  Google Scholar 

  25. Garcia-Closas R, Gonzales CA, Agudo A, Riboli E (1999) Intake of specific carotenoids and flavonoids and the risk of gastric cancer in Spain. Cancer Causes Control 10: 71–75.

    PubMed  Google Scholar 

  26. Stefani ED, Ronco A, Mendilaharsu M, Deneo-Pellegrini H (1999) Diet and risk of cancer of the upper aerodigestive tract — II: Nutrients. Oral Oncol 35: 22–26.

    PubMed  Google Scholar 

  27. Stefani ED, Boffetta P, Deneo-Pellegrini H, et al. (1999) Dietary antioxidants and lung cancer risk — a case-control study in Uruguay. Nutr Cancer 34: 100–110.

    PubMed  Google Scholar 

  28. Le Marchand, Murphy SP, Hankin JH, Wilkens LR, Kolonel LN (2000) Intake of flavonoids and lung cancer. J Natl Cancer Inst 19: 154–160.

    Google Scholar 

  29. The ATBC Cancer Prevention Study Group (1994) The Alpha-Tocopherol, Beta-Carotene Lung Cancer Study: design, methods, participant characteristics, and compliance. Ann Epidemiol 4: 1–10.

    Google Scholar 

  30. Pietinen L, Hartman AM, Haapa E, et al. (1998) Reproducibility and validity of dietary assessment instruments. I: A self-administered food use questionnaire with a portion size picture booklet. Am J Epidemiol 128: 655–666.

    Google Scholar 

  31. Hertog MGL, Hollman PC, Katan MB (1992) Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands. J Agric Food Chem 40: 2379–2383.

    Google Scholar 

  32. Hertog MGL, Hollman PC, van de Putte P (1993) Content of potentially anticarcinogenic flavonoids in tea infusions, wines, and fruit juices. J Agric Food Chem 41: 1242–1246.

    Google Scholar 

  33. Häkkinen SH, Kärenlampi SO, Heinonen IM, Mykkänen HM, Törrönen AR (1999) Content of the flavonols quercetin, myricetin and kaempherol in 25 edible berries. J Agric Food Chem 47: 2274–2279.

    PubMed  Google Scholar 

  34. Willett WC, Stampfer MJ (1986) Total energy intake — implications for epidemiologic analyses. Am J Epidemiol 124: 17–27.

    PubMed  Google Scholar 

  35. Teppo L, Pukkala L, Lehtonen M (1994) Data quality and quality control of a population-based cancer registry — experience in Finland. Acta Oncol 33: 365–369.

    PubMed  Google Scholar 

  36. Hertog MGL, Kromhout D, Aravanis C, et al. (1995) Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study. Arch Intern Med 155: 381–386.

    PubMed  Google Scholar 

  37. Wargovich MJ, Eng VW, Newmark HL (1985) Inhibition of plant phenols by benzo(a)pyrene-induced nuclear aberrations in mammalian intestinal cells: a rapid in vivo assessment method. Food Chem Toxicol 23: 47–49.

    PubMed  Google Scholar 

  38. Ogawa S, Hirayma T, Nohara M, Tokuda M, Hirai K, Fukui S (1985) The effect of quercetin on the mutagenicity of 2-acetylaminofluorene and benzo[alpha]pyrene in Salmonella typhimurium strains. Mutat Res 142: 103–107.

    PubMed  Google Scholar 

  39. Sousa RL, Marletta MA (1985) Inhibition of cytochrome P-450 activity in rat liver microsomes by the naturally occurring flavonoid, quercetin. Arch Biochem Biophys 240: 345–357.

    PubMed  Google Scholar 

  40. Das M, Khan WA, Asokan P, Bickers DR, Mukhtar H (1987) Inhibition of polycyclic aromatic hydrocarbon-DNA adduct formation in epidermis and lung of SENCAR mice by naturally occurring plant phenols. Cancer Res 47: 767–773.

    PubMed  Google Scholar 

  41. Mukhtar H, Das M, Khan WA, Wang ZY, Bik DP, Bickers DR (1988) Exceptional activity of tannic acid among naturally occurring plant phenols in protecting against 7,12-dimethyl-benz(a)anthracene-, benzo(a)pyrene, 3-methylcholanthrene-, and N-methyl-N-nitrosourea-induced skin tumorigenesis in mice. Cancer Res 48: 2361–2365.

    PubMed  Google Scholar 

  42. Le Bon AM, Siess MH, Suschetet M (1992) Inhibition of microsome-mediated binding of benzo[a]pyrene to DNA by flavonoids either in vitro or after dietary administration to rats. Chem Biol Interact 83: 65–71.

    PubMed  Google Scholar 

  43. Mendilaharsu M, De Stefani E, Deneo-Pellegrini H, Carzoglio JC, Ronco A (1998) Consumption of tea and coffee and the risk of lung cancer in cigarette-smoking men: a case-control study in Uruguya. Lung Cancer 19: 101–107.

    PubMed  Google Scholar 

  44. Mohr DL, Blot WJ, Tousey PM, Van Doren ML, Wolfe KW (1999) Southern cooking and lung cancer. Nutr Cancer 35: 34–43.

    PubMed  Google Scholar 

  45. Heilbrun LK, Nomura A, Stemmerman GN (1986) Black tea consumption and cancer risk: a prospective study. Br J Cancer 54: 677–683.

    PubMed  Google Scholar 

  46. Goldbohm RA, Hertog MGL, Brants HAM, van Poppel G, van den Brandt PA (1996) Consumption of black tea and cancer risk: a prospective cohort study. J Natl Cancer Inst 88: 93–100.

    PubMed  Google Scholar 

  47. Zheng W, Doyle TJ, Kushi LH, Sellers TA, Hong CP, Folsom AR (1996) Tea consumption and cancer incidence in a prospective cohort study of postmenopausal women. Am J Epidemiol 144: 175–182.

    PubMed  Google Scholar 

  48. Hirvonen T, Pietinen P, Virtanen M, et al. (2001) Intake of flavonols and flavones and risk of coronary heart disease in male smokers. Epidemiology 12: 62–67.

    PubMed  Google Scholar 

  49. Steinmetz KA, Potter JD (1996) Vegetables, fruit, and cancer prevention: a review. J Am Diet Assoc 96: 1027–1039.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Epidemiology and Health Promotion, National Public Health Institute, Mannerheimintie 166, Fin 0300, Helsinki, Finland

    Tero Hirvonen, Jarmo Virtamo, Pasi Korhonen & Pirjo Pietinen

  2. Division of Clinical Sciences, National Cancer Institute, Bethesda, MD, USA

    Demetrius Albanes

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Hirvonen, T., Virtamo, J., Korhonen, P. et al. Flavonol and flavone intake and the risk of cancer in male smokers (Finland). Cancer Causes Control 12, 797–802 (2001). https://doi.org/10.1023/A:1012232008016

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