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Alginate-casein microspheres as bioactive vehicles for nutrients

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Abstract

The aim of this work was to develop an alginate-casein composite microsphere as a bioactive vehicle for oral administration of nutrients by a simple extrusion dripping method. Riboflavin was selected as a model drug, and the microencapsulation efficiency was raised to 97.94% after optimizing the preparation conditions by response surface methodology. In vitro release studies showed that riboflavin was released completely from alginate-casein microspheres in simulated intestinal fluids. Meanwhile, the morphology, structure and interaction between alginate and casein were characterized by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectra.

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Author information

Authors and Affiliations

  1. State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China

    Zhimin He  (何志敏), Xiqing Zhang  (张茜青), Wei Qi  (齐 崴) & Rongxin Su  (苏荣欣)

  2. Collaborative Innovation Center of Chemical Science and Engineering(Tianjin), Tianjin, 300072, China

    Wei Qi  (齐 崴) & Rongxin Su  (苏荣欣)

  3. Tianjin Key Laboratory of Membrane Science and Desalination Technology, Tianjin University, Tianjin, 300072, China

    Wei Qi  (齐 崴) & Rongxin Su  (苏荣欣)

  4. School of Environmental Science and Engineering, Tianjin University, Tianjin, 300072, China

    Renliang Huang  (黄仁亮)

Authors
  1. Zhimin He  (何志敏)
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  2. Xiqing Zhang  (张茜青)
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  3. Wei Qi  (齐 崴)
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  4. Renliang Huang  (黄仁亮)
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  5. Rongxin Su  (苏荣欣)
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Corresponding author

Correspondence to Wei Qi  (齐 崴).

Additional information

Supported by the National High Technology Research and Development Program of China(“863” Program, No. 2013AA102204), National Natural Science Foundation of China(No. 31071509), program of Ministry of Science and Technology of China(No. 2012YQ090194), Program of Beiyang Young Scholar of Tianjin University(2012), and Program of Introducing Talents of Discipline to Universities of China(No. B06006).

Supplementary material is available in the online version of this article at http://dx.doi.org/10.1007/s12209-015-2692-5.

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He, Z., Zhang, X., Qi, W. et al. Alginate-casein microspheres as bioactive vehicles for nutrients. Trans. Tianjin Univ. 21, 383–391 (2015). https://doi.org/10.1007/s12209-015-2692-5

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  • DOI: https://doi.org/10.1007/s12209-015-2692-5

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