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18F-FDG uptake by rectal cancer is similar in mucinous and nonmucinous histological subtypes

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Annals of Nuclear Medicine Aims and scope Submit manuscript

Abstract

Purpose

PET/CT has been considered limited for the evaluation of mucinous colorectal tumors due to low 18F-FDG uptake. The aim of our study was to compare PET/CT variables in mucinous (MC) and nonmucinous (NMC) rectal adenocarcinomas.

Methods

Consecutive patients with cT2-4N0-2M0 rectal cancer included in a prospective clinical trial were reviewed. PET/CT was performed for primary baseline staging. Visual and quantitative analysis included SUVmax and SUVmean, metabolic tumor volume (MTV) and total lesion glycolysis (TLG). PET/CT parameters were compared according to histological subtypes.

Results

Overall, 73 patients were included (18 mucinous and 55 nonmucinous). SUVmax values were similar between MC and NMC (19.7 vs. 16.6; p = 0.5). MTV and TLG values were greater in the MC group (103.9 vs. 54.1; p = 0.007 and 892.5 vs. 358.8; p = 0.020) due to larger tumor volumes of MC.

Conclusions

Metabolic parameters at baseline PET/CT for patients with rectal cancer are similar in mucinous and nonmucinous histological subtypes.

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References

  1. Gallagher BM, Fowler JS, Gutterson NI, MacGregor RR, Wan C-N, Wolf AP. Metabolic trapping as a principle of radiopharmaceutical design: some factors responsible for the biodistribution of [18F] 2-deoxy-2-fluoro-d-glucose. J Nucl Med. 1978;19(10):1154–61.

    CAS  PubMed  Google Scholar 

  2. Martoni AA, Di Fabio F, Pinto C, Castellucci P, Pini S, Ceccarelli C, et al. Prospective study on the FDG-PET/CT predictive and prognostic values in patients treated with neoadjuvant chemoradiation therapy and radical surgery for locally advanced rectal cancer. Ann Oncol. 2011;22(3):650–6. doi:10.1093/annonc/mdq433.

    Article  CAS  PubMed  Google Scholar 

  3. Melton GB, Lavely WC, Jacene HA, Schulick RD, Choti MA, Wahl RL, et al. Efficacy of preoperative combined 18-fluorodeoxyglucose positron emission tomography and computed tomography for assessing primary rectal cancer response to neoadjuvant therapy. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 2007;11(8):961–9. doi:10.1007/s11605-007-0170-7 (discussion 9).

    Article  Google Scholar 

  4. Perez RO, Habr-Gama A, Gama-Rodrigues J, Proscurshim I, Juliao GP, Lynn P, et al. Accuracy of positron emission tomography/computed tomography and clinical assessment in the detection of complete rectal tumor regression after neoadjuvant chemoradiation: long-term results of a prospective trial. Cancer. 2012;118(14):3501–11. doi:10.1002/cncr.26644 (National Clinical Trial 00254683).

    Article  PubMed  Google Scholar 

  5. Cascini GL, Avallone A, Delrio P, Guida C, Tatangelo F, Marone P, et al. 18F-FDG PET is an early predictor of pathologic tumor response to preoperative radiochemotherapy in locally advanced rectal cancer. J Nucl Med. 2006;47(8):1241–8.

    CAS  PubMed  Google Scholar 

  6. Hugen N, Brown G, Glynne-Jones R, de Wilt JH, Nagtegaal ID. Advances in the care of patients with mucinous colorectal cancer. Nat Rev Clin Oncol. 2015;. doi:10.1038/nrclinonc.2015.140.

    PubMed  Google Scholar 

  7. Bosman FT. WHO classification of tumors of the digestive system. Lyon: IARC Press; 2010.

    Google Scholar 

  8. Whiteford MH, Whiteford HM, Yee LF, Ogunbiyi OA, Dehdashti F, Siegel BA, et al. Usefulness of FDG-PET scan in the assessment of suspected metastatic or recurrent adenocarcinoma of the colon and rectum. Dis Colon Rectum. 2000;43(6):759–67 (discussion 67–70).

    Article  CAS  PubMed  Google Scholar 

  9. Berger KL, Nicholson SA, Dehdashti F, Siegel BA. FDG PET evaluation of mucinous neoplasms: correlation of FDG uptake with histopathologic features. AJR Am J Roentgenol. 2000;174(4):1005–8. doi:10.2214/ajr.174.4.1741005.

    Article  CAS  PubMed  Google Scholar 

  10. Delbeke D, Martin WH. PET and PET-CT for evaluation of colorectal carcinoma. Semin Nucl Med. 2004;34(3):209–23. doi:10.1053/j.semnuclmed.2004.03.006.

    Article  PubMed  Google Scholar 

  11. O’Connor OJ, McDermott S, Slattery J, Sahani D, Blake MA. The use of PET-CT in the assessment of patients with colorectal carcinoma. Int J Surg Oncol. 2011;2011:846512. doi:10.1155/2011/846512.

    PubMed  PubMed Central  Google Scholar 

  12. Dewhurst C, Rosen MP, Blake MA, Baker ME, Cash BD, Fidler JL, et al. ACR appropriateness criteria pretreatment staging of colorectal cancer. J Am Coll Radiol. 2012;9(11):775–81. doi:10.1016/j.jacr.2012.07.025.

    Article  PubMed  Google Scholar 

  13. Gollub MJ, Grewal RK, Panu N, Thipphavong S, Sohn M, Zheng J, et al. Diagnostic accuracy of (1)(8)F-FDG PET/CT for detection of advanced colorectal adenoma. Clin Radiol. 2014;69(6):611–8. doi:10.1016/j.crad.2014.01.009.

    Article  CAS  PubMed  Google Scholar 

  14. Ozis SE, Soydal C, Akyol C, Can N, Kucuk ON, Yagci C, et al. The role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in the primary staging of rectal cancer. World J Surg Oncol. 2014;12:26. doi:10.1186/1477-7819-12-26.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Yeh CL, Chen YK. Interesting image. Utility of FDG metabolism to differentiate synchronous metastatic liver lesions from synchronous colon cancer: nonmucinous versus mucinous adenocarcinoma. Clin Nucl Med. 2010;35(1):44–6. doi:10.1097/RLU.0b013e3181c361c4.

    Article  PubMed  Google Scholar 

  16. Ay MR, Zaidi H. Assessment of errors caused by X-ray scatter and use of contrast medium when using CT-based attenuation correction in PET. Eur J Nucl Med Mol Imaging. 2006;33(11):1301–13. doi:10.1007/s00259-006-0086-6.

    Article  PubMed  Google Scholar 

  17. Soret M, Bacharach SL, Buvat I. Partial-volume effect in PET tumor imaging. J Nucl Med. 2007;48(6):932–45. doi:10.2967/jnumed.106.035774.

    Article  PubMed  Google Scholar 

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Acknowledgments

This is a retrospective study based on a prospectively collected data. The original trial was funded by two Brazilian research funding agencies: Conselho Nacional de Desenvolvimento Tecnológico e Científico (CNPq—Grant Number 483752/2006-1), and Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP—Grant Number 07/51069-01).

Author information

Authors and Affiliations

  1. University of Brasília Medical School, Av. L2 Norte quadra 605, Brasília, DF, 70840-901, Brazil

    Dalton A. dos Anjos & João B. de Sousa

  2. Angelita & Joaquim Gama Institute, Rua Manoel da Nóbrega 1564, São Paulo, SP, 04001-005, Brazil

    Angelita Habr-Gama, Bruna B. Vailati, Cecilia B. Rossi, Adelina E. Coturel, Rodrigo O. Perez & Guilherme P. São Julião

  3. Colorectal Surgery Division, University of São Paulo School of Medicine, Av. Dr. Enéas de Carvalho Aguiar, 255, São Paulo, SP, 05403-000, Brazil

    Rodrigo O. Perez

  4. Department of Radiology and Nuclear Medicine, Hospital do Coração, Rua Desembargador Eliseu Guilherme, 147, São Paulo, SP, 04004-030, Brazil

    Carlos A. Buchpiguel

  5. Hospital Universitário de Brasília, Unidade de Medicina Nuclear, Av. L2 Norte, quadra 605, anexo 2, Brasília, DF, 70840-901, Brazil

    Dalton A. dos Anjos

Authors
  1. Dalton A. dos Anjos
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  2. Angelita Habr-Gama
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  3. Bruna B. Vailati
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  4. Cecilia B. Rossi
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  5. Adelina E. Coturel
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  6. Rodrigo O. Perez
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  7. Guilherme P. São Julião
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  8. João B. de Sousa
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  9. Carlos A. Buchpiguel
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Corresponding author

Correspondence to Dalton A. dos Anjos.

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Conflict of interest

The authors declare that they have no conflict of interest.

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.

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dos Anjos, D.A., Habr-Gama, A., Vailati, B.B. et al. 18F-FDG uptake by rectal cancer is similar in mucinous and nonmucinous histological subtypes. Ann Nucl Med 30, 513–517 (2016). https://doi.org/10.1007/s12149-016-1089-4

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  • DOI: https://doi.org/10.1007/s12149-016-1089-4

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