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Biomechanical characterisation of fresh and cadaverous human small intestine: applications for abdominal trauma

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Abstract

Intestinal injuries are responsible for significant morbidity and mortality arising from trauma to the abdomen. The biomechanical characterisation of the small intestine allows for the understanding of the pathophysiological mechanisms responsible for these injuries. Studies reported in the literature focus principally on quasi-static tests, which do not take into account the stresses experienced during high kinetic trauma. In addition, the use of embalmed human tissue can alter the recorded response. The stress–strain curves from 43 tensile tests performed at 1 m/s were analysed. Samples were prepared from four fresh human intestines and from four embalmed cadaveric intestines. The data indicated a two-phase response, with each response consisting of a quasi-linear increase in the stress followed by an inflection in the curve before a peak preceding the loss of stress. The fresh tissue was more deformable than the embalmed tissue, and its first peak stress was lower (P = 0.034). A complementary histological analysis was performed. The results of the analysis enable an investigation of the response of the intestinal wall layers to stress as a two-layer structure and highlight the high sensitivity of the structure’s mechanical behaviour to the speed of loading and the method of preservation.

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Acknowledgments

We gratefully acknowledge the help provided by Dr. Cécile Conte, Dr. François Coulongeat and Ms. Marie Pauchard during the course of this study.

Conflict of interest

The authors have no conflict of interest to disclose.

Author information

Authors and Affiliations

  1. Aix-Marseille University, LBA, 13916, Marseille, France

    Stéphane Bourgouin, Thierry Bège, Catherine Masson, Pierre-Jean Arnoux, Christian Brunet & Stéphane V. Berdah

  2. IFSTTAR, LBA, 13916, Marseille, France

    Stéphane Bourgouin, Thierry Bège, Catherine Masson, Pierre-Jean Arnoux, Christian Brunet & Stéphane V. Berdah

  3. Department of Visceral and Vascular Surgery, Sainte Anne Military Teaching Hospital, Boulevard Sainte Anne, BP20545, 83041, Toulon cedex 09, France

    Stéphane Bourgouin

  4. Department of Visceral Surgery, APHM Hôpital Nord, Aix-Marseille University, 13284, Marseille, France

    Thierry Bège, Christian Brunet & Stéphane V. Berdah

  5. Department of Public Health and Medical Information, APHM la Timone, Aix-Marseille University, 13005, Marseille, France

    Julien Mancini

  6. School of Medicine, SESSTIM (UMR 912, Inserm, IRD), Aix-Marseille University, 13005, Marseille, France

    Julien Mancini

  7. Department of Anatomopathology, APHM Hôpital Nord, Aix-Marseille University, 13284, Marseille, France

    Stéphane Garcia

Authors
  1. Stéphane Bourgouin
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  2. Thierry Bège
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  3. Catherine Masson
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  4. Pierre-Jean Arnoux
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  5. Julien Mancini
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  6. Stéphane Garcia
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  7. Christian Brunet
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  8. Stéphane V. Berdah
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Corresponding author

Correspondence to Stéphane Bourgouin.

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Bourgouin, S., Bège, T., Masson, C. et al. Biomechanical characterisation of fresh and cadaverous human small intestine: applications for abdominal trauma. Med Biol Eng Comput 50, 1279–1288 (2012). https://doi.org/10.1007/s11517-012-0964-y

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  • DOI: https://doi.org/10.1007/s11517-012-0964-y

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