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Effect of cadmium on histopathological injuries and ultra-structural changes of kidney of the turtle Mauremys reevesii

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Abstract

This research investigated the effect of cadmium on the tissue and cell of kidney of the turtle Mauremys reevesii. Twenty turtles were injected with cadmium at 0, 7.5, 15, 30 mg/kg separately and five turtles were taken in each group at two weeks after exposure. Kidneys were immediately excised and macroscopic pathological changes were observed, then the kidneys were fixed in 4% paraformaldehyde for histopathological examination and fixed in 2.5% (v/v) glutaraldehyde for examination of ultra-structure. The tissues of kidney presented varying degrees of histopathological lesions in cadmium treated turtles by a dose-dependent manner under the light microscope. Under transmission electron microscope, renal tubules cells presented varying degrees of dose-dependent lesions. The results indicated that cadmium can cause cell damages to the kidney, in particular to the mitochondria. Mitochondria can be used as one biomarker in the monitoring of cadmium pollution and its quantitative risk assessments.

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References

  • Adel M, Cortés-Gómez AA, Dadar M et al (2017) A comparative study of inorganic elements in the blood of male and female Caspian pond turtles (Mauremys caspica) from the southern basin of the Caspian Sea. Environ Sci Pollut Res 24:24965–24979

    Article  CAS  Google Scholar 

  • Chora S, Starita-Geribaldi M, Guigonis JM et al (2009) Effect of cadmium in the clam Ruditapes decussates assessed by proteomic analysis. Aquat Toxicol 94(4):300–308

    Article  CAS  Google Scholar 

  • Cui JW, Liu YH, Hao ZY et al (2023) Cadmium induced time-dependent kidney injury in common carp via mitochondrial pathway: Impaired mitochondrial energy metabolism and mitochondrion-dependent apoptosis. Aquat Toxicol 261:106570–106570

    Article  CAS  Google Scholar 

  • Dieter IMDC, Jana A, Stephen G et al (2014) Genome-wide transcription profiles reveal genotype-dependent responses of biological pathways and genefamilies in Daphnia exposed to single and mixed stressors. Environ Sci Technol 48:3513–3522

    Article  Google Scholar 

  • Dong AG, Huo JF, Yan JJ et al (2021a) Lipid peroxidation of kidney of the turtle Mauremys reevesii caused by cadmium. Environ Sci Pollut Res 28:6811–6817

    Article  CAS  Google Scholar 

  • Dong AG, Huo JF, Yan JJ et al (2021b) Oxidative stress inliver of turtle Mauremys reevesii caused by cadmium. Environ Sci Pollut Res 28:6405–6410

    Article  CAS  Google Scholar 

  • Dong AG, Dong HD, He H et al (2023a) Effects of cadmium on kidney function of the freshwater turtles Mauremys reevesii. Biol Trace Elem Res 201:3000–3005

    Article  CAS  Google Scholar 

  • Dong AG, He H, Zhang TM et al (2023b) Effects of cadmium on liver function in turtle Mauremys reevesii. Environ Sci Pollut Res 30:123827–123831

    Article  CAS  Google Scholar 

  • Fordhama DF, Georges A, Corey B (2007) Optimal conditions for egg storage, incubation and post-hatching growth for the freshwater turtle, Chelodina rugosa: science in support of an indigenous enterprise. Aquaculture 270:105–114

    Article  Google Scholar 

  • Fujiwara Y, Lee JY, Tokumoto M et al (2012) Cadmium renal toxicity via apoptotic pathways. Biol Pharm Bull 35:1892–1897

    Article  CAS  Google Scholar 

  • Hagar H, Al Malki W (2014) Betaine supplementation protects against renal injury induced by cadmium intoxication in rats: Role of oxidative stress and caspase-3. Env Toxicol Pharmacol 37:803–811

    Article  CAS  Google Scholar 

  • Helen CP, Nadine ST, Joshua H et al (2011) Metabolomics of microliter hemolymph samples enables an improved understanding of the combined metabolic and transcriptional responses of Daphnia magna to cadmium. Environ Sci Technol 45:3710–3717

    Article  Google Scholar 

  • Huo JF, Dong AG, Wang YH et al (2017a) Cadmium induces histopathological injuries and ultrastructural changes in the liver of freshwater turtle (Chinemys reevesii). Chemosphere 186:459–465

    Article  CAS  Google Scholar 

  • Huo JF, Dong AG, Yan JJ et al (2017b) Cadmium toxicokinetics in the freshwater turtle, Chinemys reevesii. Chemosphere 182:392–398

    Article  CAS  Google Scholar 

  • Huo JF, Dong AG, Niu XJ et al (2018) Effects of cadmium on oxidative stress activities in plasma of freshwater turtle Chinemys reevesii. Environ Sci Pollut Res 25:8027–8034

    Article  CAS  Google Scholar 

  • Huo JF, Dong AG, Yan JJ et al (2020a) Effects of cadmium on the activities of ALT and AST as well as the content of TP in plasma of freshwater turtle Mauremys reevesii. Environ Sci Pollut Res 27:18025–18028

    Article  CAS  Google Scholar 

  • Huo JF, Dong AG, Yan JJ et al (2020b) Effects of cadmium on the gene transcription of the liver in the freshwater turtle (Chinemys reevesii). Environ Sci Pollut Res 27:8431–8438

    Article  CAS  Google Scholar 

  • Jarup L, Akesson A (2009) Current status of cadmium as an environmental health problem. Toxicol Appl Pharmacol 238:201–208

    Article  Google Scholar 

  • Jin YY, Zhou R, Kuang XY et al (2018) Research progress on renal injury induced by cadmium. J Environ Occup 35(2):180–184

    CAS  Google Scholar 

  • Lídia N, Sílvia SM, Andreia TP et al (2017) Trace elements in loggerhead turtles (Caretta caretta) stranded in mainland Portugal: Bioaccumulation and tissue distribution. Chemosphere 179:120–126

    Article  Google Scholar 

  • Liu J (1998) Study on the effect of metallothionein on cadmium toxicity in transgenic animals. Chinese J Occup Health Occup Dis 16(1):57–60

    CAS  Google Scholar 

  • Malik RN, Ghaffar B, Hashmi MZ (2013) Trace metals in Ganges soft-shell turtle (Aspideretes gangeticus) from two barrage: Baloki and Rasul, Pakistan. Environ Sci Pollut Res 20:8263–8273

    Article  CAS  Google Scholar 

  • Manuel EO, Antonio R, Pareja-Carrera J et al (2019) Tools for non-invasive sampling of metal accumulation and its effects in Mediterranean pond turtle populations inhabiting mining areas. Chemosphere 231:194–206

    Article  Google Scholar 

  • Menzie CA, Ziccardi LM, Lowney YW et al (2009) Importance of considering the framework principles in risk assessment for metals. Environ Sci Technol 43(22):78–82

    Article  Google Scholar 

  • Mohamed HRH (2022) Alleviation of Cadmium Chloride-Induced Acute Genotoxicity, Mitochondrial DNA Disruption, and ROS Generation by Chocolate Coadministration in Mice Liver and Kidney Tissues. Biol Trace Elem Res 200:3750–3761

    Article  CAS  Google Scholar 

  • Mutalib AHA, Fadzly N, Foo R (2013) Striking a balance between tradition and conservation: general perceptions and awareness level of local citizens regarding turtle conservation efforts based on age factors and gender. Ocean Coast Manag 78:56–63

    Article  Google Scholar 

  • Ouyang KW, Wang TT, Wang H et al (2024) m6A-methylated Lonp1 drives mitochondrial proteostasis stress to induce testicular pyroptosis upon environmental cadmium. Sci Total Environ 931:172938–172938

    Article  CAS  Google Scholar 

  • Pari L, Murugavel P, Sitasawad SL et al (2007) Cytoprotective and antioxidant role of diallyl tetrasulfide on cadmium induced renal injury: An in vivo and in vitro study. Life Sci 80:650–658

    Article  CAS  Google Scholar 

  • Prozialeck WC, Edwards JR, Lamar PC et al (2009) Expression of kidney injury molecule-1 (Kim-1) in relation to necrosis and apoptosis during the early stages of Cd-induced proximal tubule injury. Toxicol Appl Pharmacol 238:306–314

    Article  CAS  Google Scholar 

  • Qiu HX, Liu WM, Yan YL et al (2021) Effects of waterborne cadmium exposure on Spinibarbus sinensis hepatopancreas and kidney: Mitochondrial cadmium accumulation and respiratory metabolism. Comp Biochem Phys C 248:109115–109115

    CAS  Google Scholar 

  • Renugadevi J, Prabu SM (2010) Quercetin protects against oxidative stress-related renal dysfunction by cadmium in rats. Exp Toxicol Pathol 62:471–481

    Article  CAS  Google Scholar 

  • Rinaldi M, Micali A, Marini H et al (2017) Cadmium, Organ Toxicity and Therapeutic Approaches: A Review on Brain, Kidney and Testis Damage. Curr Med Chem 24:3879–3893

    Article  CAS  Google Scholar 

  • Rodriguez CAB, de Lacerda LD, Bezerra MF et al (2020) Influence of size on total mercury (THg), methyl mercury (MeHg), and stable isotopes of N and C in green turtles (Chelonia mydas) from NE Brazil. Environ Sci Pollut Res 27:20527–20537

    Article  CAS  Google Scholar 

  • Rose M, Fernandes A, Mortimer D et al (2015) Contamination of fish in UK fresh water systems: risk assessment for human consumption. Chemosphere 122:183–189

    Article  CAS  Google Scholar 

  • Satarug S, Baker JR, Urbenjapol S et al (2003) A global perspective on cadmium pollution and toxicity in non-occupationally exposed population. Toxicol Lett 137:65–83

    Article  CAS  Google Scholar 

  • Su M, Xu TL, Jiang FF (2001) Morphological observation of renal proximal tubular epithelial cells in chronically cadmium exposed mice. Sichuan J Anat 9(1):47

    Google Scholar 

  • Tada N, Saka M, Ueda Y et al (2004) Comparative analyses of serum vitellogenin levels in male and female Reeves’ pond turtles (Chinemys reevesii Gray) by an immunological assay. J Comp Physiol B 174:13–20

    Article  CAS  Google Scholar 

  • Thévenod F (2009) Cadmium and cellular signaling cascades: to be or not to be? Toxicol Appl Pharmacol 238:221–239

    Article  Google Scholar 

  • Thévenod F, Lee WK, Garrick MD (2020) Iron and Cadmium Entry Into Renal Mitochondria: Physiological and Toxicological Implications. Front Cell Dev Biol 8:848

    Article  Google Scholar 

  • Thévenod F, Lee WK (2013) Toxicology of cadmium and its damage to mammalian organs. In: Sigel A, Sigel H, Sigel R (eds) Cadmium: From Toxicity to Essentiality. Met Ions Life Sci 11:415–490

  • Wang Y, Fang J, Leonard SS et al (2004) Cadmium Inhibits the Electron Transfer Chain and Induces Reactive Oxygen Species. Free Radic Biol Med 36(11):1434–1443

    Article  CAS  Google Scholar 

  • Włostowski T, Dmowski K, Bonda-Ostaszewska E (2010) Cadmium accumulation, metallothionein and glutathione levels, and histo pathological changes in the kidneys and liver of magpie (Pica pica) from a zinc smelter area. Ecotoxicology 19:1066–1073

    Article  Google Scholar 

  • Wu XS, Wei S, Wei YM et al (2011) Progress in research on biomrkers of cadmium induced renal toxicity. J Environ Health 28(8):739–741

    CAS  Google Scholar 

  • Xu CX, Xu W, Lu HL (2014a) Compensatory growth responses to food restriction in the Chinese three-keeled pond turtle. Chinemys Reevesii Springerplus 3:687

    Article  Google Scholar 

  • Xu YQ, Zhu HL, Zheng YM et al (2014b) Effect of cadmium on aquatic animal kidney, mechanism and prevention. Fish Sci 12(33):804–808

    Google Scholar 

  • Zarros A, Skandali N, Al-Humadi Η et al (2008) Cadmium (Cd) as a carcinogenetic factor and its participation in the induction of lung cancer. Pneumon 21:172–177

    Google Scholar 

  • Zhang XH, Xiao XB (2012) Mechanisms and clinical prevention and treatment progress of cadmium poisoning. Pract Prev Med 19(11):1761–1763

    CAS  Google Scholar 

Download references

Acknowledgements

This study was funded by Natural Science Foundation of Shanxi Province (grant number 202203021221200), Science and Technology Innovation Ability Cultivation Plan of "Taihang Materia Medica" special basic and applied research of Shanxi University of Chinese Medicine (grant number 2022PY-TH-53, 2022PY-TH-54), Scientific Research Fund for the Doctoral Scholars, Shanxi University of Chinese Medicine (grant number 2023BK44).

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Authors and Affiliations

  1. Shanxi University of Chinese Medicine, Taiyuan, Shanxi Province, China

    Aiguo Dong, Yingying Ma, Xinling Wang, Xuejie Jing, Hui He, Tianmiao Zhang, Huidong Dong, Wei Liu, Kaifang Fan & Junfeng Huo

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  1. Aiguo Dong
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  2. Yingying Ma
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  3. Xinling Wang
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  4. Xuejie Jing
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Contributions

Aiguo Dong designed the study, performed the research, analyzed data, and wrote the paper. Yingying Ma wrote the paper. Xinling Wang wrote the paper. Xuejie Jing was one contributor in writing the manuscript. Hui He was one contributor in writing the manuscript. Tianmiao Zhang was one contributor in writing the manuscript. Huidong Dong was one contributor in writing the manuscript. Wei Liu was one contributor in writing the manuscript. Kaifang Fan designed the study. Junfeng Huo designed the study, performed the research, analyzed data, and wrote the paper. All authors read and approved the final manuscript.

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Correspondence to Junfeng Huo.

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This study was approved by Shanxi University of Chinese Medicine (permit number: 2022DW037).

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All the authors declared that there was no conflict of interests regarding the publication of this article.

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Aiguo Dong, Yingying Ma, Xinling Wang and Junfeng Huo Joint first co-authorship. The authors contributed equally to this work

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Dong, A., Ma, Y., Wang, X. et al. Effect of cadmium on histopathological injuries and ultra-structural changes of kidney of the turtle Mauremys reevesii. Environ Sci Pollut Res 31, 39774–39781 (2024). https://doi.org/10.1007/s11356-024-33904-8

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