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Gut microbiota and acute kidney injury: immunological crosstalk link

  • Nephrology - Review
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Abstract

The gut microbiota, often called the "forgotten organ," plays a crucial role in bidirectional communication with the host for optimal physiological function. This communication helps regulate the host’s immunity and metabolism positively and negatively. Many factors influence microbiota homeostasis and subsequently lead to an immune system imbalance. The correlation between an unbalanced immune system and acute diseases such as acute kidney injury is not fully understood, and the role of gut microbiota in disease pathogenesis is still yet uncovered. This review summarizes our understanding of gut microbiota, focusing on the interactions between the host’s immune system and the microbiome and their impact on acute kidney injury.

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Authors and Affiliations

  1. Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, 212013, China

    Asmaa Ali

  2. Department of Pulmonary Medicine, Abbassia Chest Hospital, MOH, Cairo, Egypt

    Asmaa Ali

  3. Department of Respiratory Allergy, A Al-Rashed Allergy Center, Ministry of Health, Kuwait, Kuwait

    Asmaa Ali

  4. Yizheng Hospital, Nanjing Drum Tower Hospital Group, Yizheng, 210008, China

    Liang Wu

  5. School of the Environment and Safety Engineering, Biofuels Institute, Jiangsu University, Zhenjiang, 212013, China

    Sameh Samir Ali

  6. Botany Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt

    Sameh Samir Ali

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All authors contributed to the study conception and design. Data collection was performed by Asmaa Ali and Wu Liang. The first draft of the manuscript was written by Asmaa Ali. Asmaa Ali, Wu Liang and Sameh Samir Ali wrote the second draft, all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Ali, A., Wu, L. & Ali, S.S. Gut microbiota and acute kidney injury: immunological crosstalk link. Int Urol Nephrol 56, 1345–1358 (2024). https://doi.org/10.1007/s11255-023-03760-5

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