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Synthesis of lupane triterpenoids with triphenylphosphonium substituents and studies of their antitumor activity

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Abstract

New derivatives of lupane triterpenoids, viz., 20,29-dihydrobetulinic and 3-epi-20,29-dihydrobetulinic acid derivatives containing triphenylphosphonium fragments as substituents were synthesized. These compound considerably exceed betulinic acid in antitumor activity.

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Authors and Affiliations

  1. Institute of Petrochemistry and Catalysis, Russian Academy of Sciences, 141 prosp. Oktyabrya, 450075, Ufa, Russian Federation

    A. Yu. Spivak, D. A. Nedopekina, E. R. Shakurova, R. R. Khalitova, R. R. Gubaidullin, V. N. Odinokov & U. M. Dzhemilev

  2. Innovative Pharmacology Research (IPHAR), 8/8 prosp. Akademicheskii, 634055, Tomsk, Russian Federation

    Yu. P. Bel’skii, N. V. Bel’skaya, S. A. Stankevich, E. V. Korotkaya & V. A. Khazanov

Authors
  1. A. Yu. Spivak
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  2. D. A. Nedopekina
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  3. E. R. Shakurova
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  4. R. R. Khalitova
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  5. R. R. Gubaidullin
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  6. V. N. Odinokov
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  7. U. M. Dzhemilev
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  8. Yu. P. Bel’skii
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  9. N. V. Bel’skaya
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  10. S. A. Stankevich
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  11. E. V. Korotkaya
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  12. V. A. Khazanov
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Corresponding author

Correspondence to A. Yu. Spivak.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 0189–0199, January, 2013.

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Spivak, A.Y., Nedopekina, D.A., Shakurova, E.R. et al. Synthesis of lupane triterpenoids with triphenylphosphonium substituents and studies of their antitumor activity. Russ Chem Bull 62, 188–198 (2013). https://doi.org/10.1007/s11172-013-0028-y

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  • DOI: https://doi.org/10.1007/s11172-013-0028-y

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