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Multifunctional Nanoparticulate Polyelectrolyte Complexes

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An Erratum to this article was published on 29 May 2008

Abstract

Water-soluble, biodegradable, polymeric, polyelectrolyte complex dispersions (PECs) have evolved because of the limitations, in terms of toxicity, of the currently available systems. These aqueous nanoparticulate architectures offer a significant advantage for products that may be used as drug delivery systems in humans. PECs are created by mixing oppositely charged polyions. Their hydrodynamic diameter, surface charge, and polydispersity are highly dependent on concentration, ionic strength, pH, and molecular parameters of the polymers that are used. In particular, the complexation between polyelectrolytes with significantly different molecular weights leads to the formation of water-insoluble aggregates. Several PEC characteristics are favorable for cellular uptake and colloidal stability, including hydrodynamic diameter less than 200 nm, surface charge of >30 mV or <−30 mV, spherical morphology, and polydispersity index (PDI) indicative of a homogeneous distribution. Maintenance of these properties is critical for a successful delivery vehicle. This review focuses on the development and potential applications of PECs as multi-functional, site-specific nanoparticulate drug/gene delivery and imaging devices.

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Acknowledgment

We acknowledge support of National Institutes of Health Grants 1R01EB002825-01 (J.M.D. and A.P.), support from the Department of Veterans Affairs (J.M.D.), the University of Texas MD Anderson Odyssey Fellowship, and the TN Law Foundation (S.M.H.). In addition we would like to thank the Vanderbilt Institute for Nanoscale Science and Engineering (VINSE) for use of the Malvern ZetaSizer Nano ZS.

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Authors and Affiliations

  1. Divison of Pediatrics Research, University of Texas MD Anderson Cancer Center, Houston, Texas, 77030-4009, USA

    Sean M. Hartig

  2. Department of Chemical Engineering, Vanderbilt University, Nashville, Tennessee, 37235-1604, USA

    Rachel R. Greene & Ales Prokop

  3. Department of Medicine, Hematology/Oncology Division, Vanderbilt University School of Medicine, Nashville, Tennessee, 37232-2562, USA

    Mikhail M. Dikov

  4. Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee, 37232-2562, USA

    Jeffrey M. Davidson

  5. Research Service, VA Tennessee Valley Healthcare System, Nashville, Tennessee, 37212-2637, USA

    Jeffrey M. Davidson

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  1. Sean M. Hartig
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  2. Rachel R. Greene
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  3. Mikhail M. Dikov
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  4. Ales Prokop
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Correspondence to Jeffrey M. Davidson.

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An erratum to this article can be found at http://dx.doi.org/10.1007/s11095-008-9623-2

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Hartig, S.M., Greene, R.R., Dikov, M.M. et al. Multifunctional Nanoparticulate Polyelectrolyte Complexes. Pharm Res 24, 2353–2369 (2007). https://doi.org/10.1007/s11095-007-9459-1

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