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Research Progress on Alzheimer's Disease and Resveratrol

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Abstract

Alzheimer's disease (AD), a common irreversible neurodegenerative disease characterized by amyloid-β plaques, neurofibrillary tangles, and changes in tau phosphorylation, is accompanied by memory loss and symptoms of cognitive dysfunction. Increases in disease incidence due to the ageing of the population have placed a great burden on society. To date, the mechanism of AD and the identities of adequate drugs for AD prevention and treatment have eluded the medical community. It has been confirmed that phytochemicals have certain neuroprotective effects against AD. For example, some progress has been made in research on the use of resveratrol, a natural polyphenolic phytochemical, for the prevention and treatment of AD in recent years. Elucidation of the pathogenesis of AD will create a solid foundation for drug treatment. In addition, research on resveratrol, including its mechanism of action, the roles of signalling pathways and its therapeutic targets, will provide new ideas for AD treatment, which is of great significance. In this review, we discuss the possible relationships between AD and the following factors: synapses, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs), silent information regulator 1 (SIRT1), and estrogens. We also discuss the findings of previous studies regarding these relationships in the context of AD treatment and further summarize research progress related to resveratrol treatment.

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Funding

This funding was supported by Traditional Chinese medicine scientific research project of the Guangdong Traditional Chinese Medicine Bureau [Grant Number 20162078], Guangdong Provincial Science and Technology Plan 2017 Science and Technology Development Fund [Grant Number 2017A020215061], Shandong Education Science Plan (CN) [Grant Number 2016105101290], Collaborative Innovation Center for Modern Science and Technology and Industrial Development of Jiangxi Traditional Medicine (CN) [Grant Number 2018A01029], Special fund for Zhanjiang Science and Technology Development [Grant Number 2018A206], National fund training project for young and middle-aged researchers of Guangdong Medical University [Grant Number 10264SG19055G].

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  1. The Department of Epidemiology and Health Statistics, Public Health School of Guangdong Medical University, Dongguan, 523808, Guangdong, China

    Yan Yan, Huihuang Yang, Yuxun Xie, Yuanlin Ding, Danli Kong & Haibing Yu

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Yan, Y., Yang, H., Xie, Y. et al. Research Progress on Alzheimer's Disease and Resveratrol. Neurochem Res 45, 989–1006 (2020). https://doi.org/10.1007/s11064-020-03007-0

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