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Artificial Intelligence Techniques for the effective diagnosis of Alzheimer’s Disease: A Review

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Abstract

Alzheimer's disease (AD) is a progressive and irreversible neurological disorder that leads to memory loss and cognitive decline. It is a prevalent form of dementia among individuals aged 65 and above. Accurate and early diagnosis of AD is of utmost importance. Diagnostic neuroimaging and software techniques have emerged as crucial tools for assessing early-stage dementia. The aim of this study is to provide a comprehensive review of recent research that employs deep learning (DL) techniques for the assessment of dementia, particularly the early stages of AD. The objective is to analyze the current state of research and explore the future directions of this field. The study involves a systematic review of literature that focuses on the utilization of DL techniques in the assessment of dementia and early AD diagnosis. Various datasets commonly used for AD prediction are examined. The study encompasses the discussion of different applications of contemporary AI algorithms in AD detection, as well as their merits, limitations, and performance. The review reveals that DL techniques have shown promise in the detection and diagnosis of AD. The use of DL, particularly in image classification and natural language processing, has demonstrated significant advancements in the field of AI. The study also highlights the potential of AI in AD genetic studies, providing valuable insights into the broad scope of this research.

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References

  1. Ganasegeran K, Ch’ng A, Looi I (2021) Artificial intelligence for risk prediction of Alzheimer’s disease: a new promise for community health screening in the older aged. In: Handbook of decision support systems for neurological disorders, 1st edn (Chap. 5). Elsevier Academic Press, pp 71–88

  2. El-Sappagh S, Abuhmed T, Alouffi B, Sahal R, Abdelhade N, Saleh H (2021) The role of medication data to enhance the prediction of Alzheimer’s progression using machine learning. Comput Intell Neurosci 2021:8439655. https://doi.org/10.1155/2021/8439655

  3. Subetha T, Khilar R, Sahoo SK (2020) An early prediction and detection of Alzheimer’s disease: a comparative analysis on various assistive technologies. Int Conference Computational Intell Smart Power System SustainEnergy (CISPSSE) 2020:1–5. https://doi.org/10.1109/CISPSSE49931.2020.9212240

    Article  Google Scholar 

  4. Bi X, Liu W, Liu H, Shang Q (2021) Artificial intelligence-based MRI images for brain in prediction of Alzheimer’s disease. J Healthcare Eng 2021(8198552):7. https://doi.org/10.1155/2021/8198552

    Article  Google Scholar 

  5. Li H, Fan Y (2019) Early prediction of alzheimer’s disease dementia based on baseline hippocampal MRI and 1-year follow-up cognitive measures using deep recurrent neural networks. 2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019). Venice, Italy 2019:368–371. https://doi.org/10.1109/ISBI.2019.8759397

    Article  Google Scholar 

  6. A ID JC et al. (2019) "Deep-learning prediction of mild cognitive impairment using electronic health records". 799–806

  7. Fang X, Liu Z, Xu M (2020) Ensemble of deep convolutional neural networks based multi-modality images for Alzheimer’s disease diagnosis. IET Image Process 14(2):318–326

    Google Scholar 

  8. Vinyals O, Babuschkin I, Czarnecki WM, Mathieu M, Dudzik A, Chung J, Choi DH, Powell R, Ewalds T, Georgiev P et al (2019) Grandmaster level in StarCraft II using multi-agent reinforcement learning. Nature 575:350–354

    Google Scholar 

  9. Crigger E, Reinbold K, Hanson C, Kao A, Blake K, Irons M (2022) Trustworthy augmented intelligence in health care. J Med Syst 46(2):12. https://doi.org/10.1007/s10916-021-01790-z

    Article  Google Scholar 

  10. Mitchell TM (1997) Machine learning. McGraw-Hill, Inc. Professional Book Group 11 West 19th Street New York, NY, p 432

  11. LeCun Y, Bengio Y, Hinton G (2015) Deep learning. Nature 521:436–444

    Google Scholar 

  12. Tolar M, Hey J, Power A, Abushakra S (2021) Neurotoxic soluble amyloid oligomers drive Alzheimer’s pathogenesis and represent a clinically validated target for slowing disease progression. Int J Mol Sci 22:6355

    Google Scholar 

  13. Mishra R, Li B (2020) The application of artificial intelligence in the genetic study of Alzheimer’s disease. Aging Dis 11:1567–1584

    Google Scholar 

  14. Schneider G (2018) Automating drug discovery. Nat Rev Drug Discov 17:97–113

    Google Scholar 

  15. Zhang M, Schmitt-Ulms G, Sato C, Xi Z, Zhang Y, Zhou Y, St George-Hyslop P, Rogaeva E (2016) Drug repositioning for Alzheimer’s disease based on systematic ‘Omics’ data mining. PLoS ONE 11:e0168812

    Google Scholar 

  16. Kumar S, Chowdhury S, Kumar S (2017) In silico repurposing of antipsychotic drugs for Alzheimer’s disease. BMC Neurosci 18:76

    Google Scholar 

  17. Xu Y, Kong J, Hu P (2021) Computational drug repurposing for Alzheimer’s disease using risk genes from GWAS and single-cell RNA sequencing studies. Front Pharmacol 12:617537

    Google Scholar 

  18. Harrer S, Shah P, Antony B, Hu J (2019) Artificial intelligence for clinical trial design. Trends Pharmacol Sci 40:577–591

    Google Scholar 

  19. He J, Baxter SL, Xu J, Xu J, Zhou X, Zhang K (2019) The practical implementation of artificial intelligence technologies in medicine. Nat Med 25:30–36

    Google Scholar 

  20. Tran BX, Vu GT, Ha GH, Vuong Q-H, Ho M-T, Vuong T-T, La V-P, Ho M-T, Nghiem K-CP, Nguyen HLT (2019) Global evolution of research in artificial intelligence in health and medicine: A Bibliometric Study. J Clin Med 8:360

    Google Scholar 

  21. Termine A, Fabrizio C, Strafella C, Caputo V, Petrosini L, Caltagirone C, Giardina E, Cascella R (2021) Multi-layer picture of neurodegenerative diseases: lessons from the use of big data through artificial intelligence. J Pers Med 11:280

    Google Scholar 

  22. Beekly DL, Ramos EM, Lee WW, Deitrich WD, Jacka ME, Wu J, Hubbard JL, Koepsell TD, Morris JC, Kukull WA et al (2007) The national Alzheimer’s coordinating center (NACC) database: the uniform data set. Alzheimer Dis Assoc Disord 21:249–258

    Google Scholar 

  23. Haider F, de la Fuente S, Luz S (2020) An assessment of paralinguistic acoustic features for detection of Alzheimer’s dementia in spontaneous speech. IEEE J Sel Top Signal Process 14:272–281

    Google Scholar 

  24. Becker JT, Boiler F, Lopez OL, Saxton J, McGonigle KL (1994) The natural history of Alzheimer’s disease: description of study cohort and accuracy of diagnosis. Arch Neurol 51:585–594

    Google Scholar 

  25. Edgar R, Domrachev M, Lash AE (2002) Gene expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 30:207–210

    Google Scholar 

  26. Sudlow C, Gallacher J, Allen N, Beral V, Burton P, Danesh J, Downey P, Elliott P, Green J, Landray M et al (2015) UK biobank: an open access resource for identifying the causes of aWide range of complex diseases of middle and old age. PLoS Med 12:e1001779

    Google Scholar 

  27. Li H, Habes M, Wolk DA, Fan Y (2019) A deep-learning model for early prediction of Alzheimer’s disease dementia based on hippocampal magnetic resonance imaging data. Alzheimer’s Dement 15(8):1059–1070

    Google Scholar 

  28. Tibshirani R (1997) The lasso method for variable selection in the cox model. Stat Med 16(4):385–395

    Google Scholar 

  29. Cui Z, Gao Z, Leng J, Zhang T, Quan P, Zhao W (2019) Alzheimer’s disease diagnosis using enhanced inception network based on brain magnetic resonance image. 2019 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). San Diego, CA,  pp 2324–2330. https://doi.org/10.1109/BIBM47256.2019.8983046

  30. Smith P, Reid DB, Environment C, Palo L, Alto P, Smith PL et al (1979) A threshold selection method from gray-level histograms,". IEEE Trans Syst Man Cybern 20(1):62–66

    Google Scholar 

  31. Basaia S et al (2019) Automated classification of Alzheimer’s disease and mild cognitive impairment using a single MRI and deep neural networks. NeuroImage Clin 21:101645

    Google Scholar 

  32. Amin-Naji M, Mahdavinataj H, Aghagolzadeh A (2019) “Alzheimer’s disease diagnosis from structural MRI using Siamese convolutional neural network,” 4th Int. Conf Pattern Recognit Image Anal IPRIA 2019:75–79

    Google Scholar 

  33. Liu M, Zhang J, Adeli E, Shen D (2019) Joint classification and regression via deep multi-task multi-channel learning for Alzheimer’s disease diagnosis. IEEE Trans Biomed Eng 66(5):1195–1206

    Google Scholar 

  34. Liu M, Zhang J, Lian C, Shen D (2020) Weakly Supervised Deep Learning for Brain Disease Prognosis Using MRI and Incomplete Clinical Scores. IEEE Trans Cybern 50(7):3381–3392. https://doi.org/10.1109/TCYB.2019.2904186

    Article  Google Scholar 

  35. Martinez-Murcia FJ, Ortiz A, Gorriz JM, Ramirez J, Castillo-Barnes D (2020) Studying the manifold structure of Alzheimer’s disease: a deep-learning approach using convolutional autoencoders. IEEE J Biomed Heal Informatics 24(1):17–26

    Google Scholar 

  36. Gao XW, Hui R, Tian Z (2017) Classification of CT brain images based on deep-learning networks. Comput Methods Programs Biomed 138:49–56

    Google Scholar 

  37. Kavitha M, Yudistira N, Kurita T (2019) Multi instance learning via deep CNN for multi-class recognition of Alzheimer’s disease. 2019 IEEE 11th International Workshop on Computational Intelligence and Applications (IWCIA), Hiroshima, Japan, pp 89–94. https://doi.org/10.1109/IWCIA47330.2019.8955006

  38. Taqi AM, Awad A, Al-Azzo F, Milanova M (2018) The impact of multi-optimizers and data augmentation on tensorflow convolutional neural network Performance. 2018 IEEE Conference on Multimedia Information Processing and Retrieval (MIPR). Miami, FL, pp 140–145. https://doi.org/10.1109/MIPR.2018.00032

  39. Yue L, Gong X, Chen K, Mao M, Li J, Nandi AK, Maozhen Li (2018) Auto-detection of Alzheimer’s disease using deep convolutional neural networks. 2018 14th International Conference on Natural Computation, Fuzzy Systems and Knowledge Discovery (ICNC-FSKD). Huangshan, China, pp 228–234. https://doi.org/10.1109/FSKD.2018.8687207

  40. Senanayake U, Sowmya A, Dawes L (2018) Deep fusion pipeline for mild cognitive impairment diagnosis. 2018 IEEE 15th International Symposium on Biomedical Imaging (ISBI 2018). Washington, DC, pp 1394–1997. https://doi.org/10.1109/ISBI.2018.8363832

  41. Jarrett D, Yoon J, Van Der Schaar M (2020) Dynamic prediction in clinical survival analysis using temporal convolutional networks. IEEE J Biomed Heal Informatics 24(2):424–436

    Google Scholar 

  42. Fedorov A, Devon Hjelm R, Abrol A, Fu Z, Du Y, Plis S, Calhoun V (2019) Prediction of Progression to Alzheimer's disease with Deep InfoMax. 2019 IEEE EMBS International Conference on Biomedical & Health Informatics (BHI). Chicago, IL, pp 1–5. https://doi.org/10.1109/BHI.2019.8834630

  43. Devon Hjelm R, Fedorov A, Lavoie-Marchildon S, Grewal K, Bachman P, Trischler A, Bengio Y (2019) Learning deep representations by mutual information estimation and maximization. 7th International Conference on Learning Representations, ICLR. New Orleans, LA, pp 1–24

  44. Zhao X, Zhou F, Ou-Yang L, Wang T, Lei B (2019) Graph Convolutional Network Analysis for Mild Cognitive Impairment Prediction. IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019). Venice, Italy, pp 1598–1601. https://doi.org/10.1109/ISBI.2019.8759256

  45. Guo J, Qiu W, Li X, Zhao X, Guo N, Li Q (2019) Predicting Alzheimer’s disease by hierarchical graph convolution from positron emission tomography imaging. In 2019 IEEE International Conference on Big Data (Big Data). Los Angeles, CA, pp 5359–5363. https://doi.org/10.1109/BigData47090.2019.9005971

  46. Li F, Liu M (2018) Alzheimer’s disease diagnosis based on multiple cluster dense convolutional networks. Comput Med Imaging Graph 70:101–110

    Google Scholar 

  47. Jabason E, Ahmad MO, Swamy MNS (2019) Classification of Alzheimer’s disease from mri data using an ensemble of hybrid deep convolutional neural networks. IEEE 62nd International Midwest Symposium on Circuits and Systems (MWSCAS). Dallas, TX, pp 481–484. https://doi.org/10.1109/MWSCAS.2019.8884939

  48. Studholme C, Hill DLG, Hawkes DJ (1999) An overlap invariant entropy measure of 3D medical image alignment. Pattern Recognit 32(1):71–86

    Google Scholar 

  49. Choi JY, Lee B (2020) Combining of multiple deep networks via ensemble generalization loss, based on MRI images, for Alzheimer’s disease classification. IEEE Signal Process Lett 27:206–210

    Google Scholar 

  50. Fang X, Liu Z, Xu M (2020) Ensemble of deep convolutional neural networks based multi-modality images for Alzheimer’s disease diagnosis. IET Image Processing 14(2):318–326. https://doi.org/10.1049/iet-ipr.2019.0617

    Article  Google Scholar 

  51. Srivastava N, Mansimov E, Salakhutdinov R (2015) Unsupervised learning of video representations using LSTMs, ICML’15: Proceedings of the 32nd International Conference on International Conference on Machine Learning, vol 37, p 843–852

  52. Lee G et al (2019) Predicting Alzheimer’s disease progression using multi-modal deep-learning approach. Sci Rep 9(1):1–12

    MathSciNet  Google Scholar 

  53. Chitradevi D, Prabha S (2020) Analysis of brain sub-regions using optimization techniques and deep-learning method in Alzheimer’s disease. Appl Soft Comput J 86:105857

    Google Scholar 

  54. Fisher CK, Smith AM, Walsh JR (2019) Machine learning for comprehensive forecasting of Alzheimer’s Disease progression. Sci Rep 9:13622. https://doi.org/10.1038/s41598-019-49656-2

  55. E. Lee, J. S. Choi, M. Kim, and H. Il Suk, "Toward an interpretable Alzheimer's disease diagnostic model with regional abnormality representation via deep-learning," Neuroimage, vol. 202, no. December 2018, 2019

  56. Lee E, Choi J-S, Kim M, Suk H-I (2019) Toward an interpretable Alzheimer’s disease diagnostic model with regional abnormality representation via deep learning, NeuroImage 202. https://doi.org/10.1016/j.neuroimage.2019.116113

  57. Khan NM, Abraham N, Hon M (2019) Transfer learning with intelligent training data selection for prediction of Alzheimer’s disease. IEEE Access 7:72726–72735

    Google Scholar 

  58. Ebrahimi-Ghahnavieh A, Luo S, Chiong R (2019) Transfer learning for Alzheimer’s disease detection on MRI images. Proc. - 2019 IEEE Int. Conf. Ind. 4.0. Artif Intell Commun Technol IAICT 2019:133–138

    Google Scholar 

  59. Studholme C, Hill DLG, Hawkes DJ (1999) An overlap invariant entropy measure of 3D medical image alignment. Pattern Recognition 32(1):71–86. https://doi.org/10.1016/S0031-3203(98)00091-0

    Article  Google Scholar 

  60. Albright J (2019) Forecasting the progression of Alzheimer’s disease using neural networks and a novel preprocessing algorithm. Alzheimer’s Dement Transl Res Clin Interv 5:483–491

    Google Scholar 

  61. Aderghal K, Khvostikov A, Krylov A, Benois-Pineau J, Afdel K, Catheline G (2018) Classification of Alzheimer disease on imaging modalities with deep CNNs using cross-modal transfer learning. IEEE 31st International Symposium on Computer-Based Medical Systems (CBMS). Karlstad, Sweden, pp 345–350. https://doi.org/10.1109/CBMS.2018.00067

  62. Hao X et al (2020) Multi-modal neuroimaging feature selection with consistent metric constraint for diagnosis of Alzheimer’s disease. Med Image Anal 60:101625

    Google Scholar 

  63. Frazer KA, Murray SS, Schork NJ, Topol EJ (2009) Human genetic variation and its contribution to complex traits. Nat Rev Genet 10:241–251

    Google Scholar 

  64. Mazzocchi F (2008) Complexity in biology. Exceeding the limits of reductionism and determinism using complexity theory. EMBO Rep 9:10–14

    Google Scholar 

  65. Zitnik M, Nguyen F, Wang B, Leskovec J, Goldenberg A, Hoffman MM (2019) Machine learning for integrating data in biology and medicine: principles, practice, and opportunities. Inf Fusion 50:71–91

    Google Scholar 

  66. Rajkomar A, Dean J, Kohane I (2019) Machine learning in medicine. N Engl J Med 380:1347–1358

    Google Scholar 

  67. Webb S (2018) Deep learning for biology. Nature 554:555–557

    Google Scholar 

  68. Tran BX, Vu GT, Ha GH, Vuong QH, Ho MT, Vuong TT et al (2019) Global evolution of research in artificial intelligence in health and medicine: a bibliometric study. J Clin Med 8:360

    Google Scholar 

  69. Lee Y, Ragguett RM, Mansur RB, Boutilier JJ, Rosenblat JD, Trevizol A et al (2018) Applications of machine learning algorithms to predict therapeutic outcomes in depression: A meta-analysis and systematic review. J Affect Disord 241:519–532

    Google Scholar 

  70. Gatz M, Reynolds CA, Fratiglioni L, Johansson B, Mortimer JA, Berg S et al (2006) Role of genes and environments for explaining Alzheimer disease. Arch Gen Psychiatry 63:168–174

    Google Scholar 

  71. Ballard C, Gauthier S, Corbett A, Brayne C, Aarsland D, Jones E (2011) Alzheimer’s disease. Lancet 377:1019–1031

    Google Scholar 

  72. Ku CS, Loy EY, Salim A, Pawitan Y, Chia KS (2010) The discovery of human genetic variations and their use as disease markers: Past, present and future. J Hum Genet 55:403–415

    Google Scholar 

  73. Telenti A, Lippert C, Chang PC, DePristo M (2018) Deep learning of genomic variation and regulatory network data. Hum Mol Genet 27(R1):R63–R71

    Google Scholar 

  74. Maston GA, Evans SK, Green MR (2006) Transcriptional regulatory elements in the human genome. Annu Rev Genomics Hum Genet 7:29–59

    Google Scholar 

  75. ENCODE Project Consortium (2012) An integrated encyclopedia of DNA elements in the human genome. Nature 489:57–74

    Google Scholar 

  76. Fenoglio C, Scarpini E, Serpente M, Galimberti D (2018) Role of genetics and epigenetics in the pathogenesis of Alzheimer’s disease and frontotemporal dementia. J Alzheimers Dis 62:913–932

    Google Scholar 

  77. Fabrizio C, Termine A, Caltagirone C, Sancesario G (2021) Artificial intelligence for Alzheimer’s disease: Promise or challenge? Diagnostics (Basel) 11(8):1473. https://doi.org/10.3390/diagnostics11081473.PMID:34441407;PMCID:PMC8391160

    Article  Google Scholar 

  78. Spalletta G, Piras F, Piras F, Sancesario G, Iorio M, Fratangeli C, Cacciari C, Caltagirone C, Orfei MD (2014) Neuroanatomical correlates of awareness of illness in patients with amnestic mild cognitive impairment who will or will not convert to Alzheimer’s disease. Cortex 61:183–195

    Google Scholar 

  79. Giulietti G, Torso M, Serra L, Spanò B, Marra C, Caltagirone C, Cercignani M, Bozzali M. (2018) Alzheimer’s disease neuroimaging initiative (ADNI) whole brain white matter histogram analysis of diffusion tensor imaging data detects microstructural damage in mild cognitive impairment and Alzheimer’s disease patients. J Magn Reson Imaging

  80. Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Petersen RC et al (2011) The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association Workgroups on Diagnostic Guidelines for Alzheimer’s Disease. Alzheimer’s Dement 7:270–279

    Google Scholar 

  81. McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR, Kawas CH, Klunk WE, Koroshetz WJ, Manly JJ, Mayeux R et al (2011) The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association Workgroups on Diagnostic Guidelines for Alzheimer’s Disease. Alzheimer’s Dement 7:263–269

    Google Scholar 

  82. Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, Iwatsubo T, Jack CR, Kaye J, Montine TJ et al (2011) Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association Workgroups on Diagnostic Guidelines for Alzheimer’s Disease. Alzheimer’s Dement 7:280–292

    Google Scholar 

  83. Jack CR, Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, Holtzman DM, Jagust W, Jessen F, Karlawish J et al (2018) NIA-AA research framework: toward a biological definition of Alzheimer’s disease. Alzheimer’s Dement 14:535–562

    Google Scholar 

  84. Williamson J, Goldman J, Marder KS (2009) Genetic aspects of Alzheimer disease. Neurologist 15:80–86

    Google Scholar 

  85. Salas-Gonzalez D, Górriz JM, Ramírez J, López M, Álvarez I, Segovia F, Puntonet CG (2009) Computer aided diagnosis of Alzheimer disease using support vector machines and classification trees. In: Köppen M, Kasabov N, Coghill G (eds) advances in neuro-information processing. Springer, Berlin/Heidelberg, Germany, pp 418–425

    Google Scholar 

  86. Gorriz JM, Ramirez J, Lassl A, Salas-Gonzalez D, Lang EW, Puntonet CG, Alvarez I, Lopez M, Gomez-Rio M. (2008) Automatic computer aided diagnosis tool using component-based SVM. In proceedings of the 2008 IEEE nuclear science symposium conference record, Dresden, Germany, 19–25 October 2008. 4392–4395

  87. Marcus DS, Wang TH, Parker J, Csernansky JG, Morris JC, Buckner RL (2007) Open Access Series of Imaging Studies (OASIS): Cross-Sectional MRI Data in Young, Middle Aged, Nondemented, and Demented Older Adults. J Cogn Neurosci 19:1498–1507

    Google Scholar 

  88. Zhang Y, Dong Z, Phillips P, Wang S, Ji G, Yang J, Yuan TF. (2015) Detection of subjects and brain regions related to Alzheimer’s disease using 3D MRI scans based on Eigenbrain and machine learning. Front. Comput Neurosci 9

  89. Ding Y, Sohn JH, Kawczynski MG, Trivedi H, Harnish R, Jenkins NW, Lituiev D, Copeland TP, Aboian MS, Mari Aparici C et al (2019) A deep learning model to predict a diagnosis of Alzheimer disease by using 18F-FDG PET of the brain. Radiology 290:456–464

    Google Scholar 

  90. Rathore S, Habes M, Iftikhar MA, Shacklett A, Davatzikos C (2017) A review on neuroimaging-based classification studies and associated feature extraction methods for Alzheimer’s disease and its prodromal stages. Neuroimage 155:530–548

    Google Scholar 

  91. Binaco R, Calzaretto N, Epifano J, McGuire S, Umer M, Emrani S, Wasserman V, Libon DJ, Polikar R (2020) Machine learning analysis of digital clock drawing test performance for differential classification of mild cognitive impairment subtypes versus Alzheimer’s disease. J Int Neuropsychol Soc 26:690–700

    Google Scholar 

  92. Spasov S, Passamonti L, Duggento A, Liò P, Toschi N (2019) A parameter-efficient deep learning approach to predict conversion from mild cognitive impairment to Alzheimer’s disease. Neuroimage 189:276–287

    Google Scholar 

  93. Bae J, Stocks J, Heywood A, Jung Y, Jenkins L, Hill V, Katsaggelos A, Popuri K, Rosen H, Beg MF et al (2020) Transfer learning for predicting conversion from mild cognitive impairment to dementia of Alzheimer’s type based on a three-dimensional convolutional neural network. Neurobiol Aging 99:53–64

    Google Scholar 

  94. Cabral C, Morgado PM, Costa DC, Silveira M (2015) Alzheimer’s disease neuroimaging initiative predicting conversion from MCI to AD with FDG-PET brain images at different prodromal stages. Comput Biol Med 58:101–109

    Google Scholar 

  95. Cheng B, Liu M, Zhang D, Munsell BC, Shen D (2015) Domain transfer learning for MCI conversion prediction. IEEE Trans Biomed Eng 62:1805–1817

    Google Scholar 

  96. Cuingnet R, Gerardin E, Tessieras J, Auzias G, Lehéricy S, Habert M-O, Chupin M, Benali H, Colliot O (2011) Alzheimer’s disease neuroimaging initiative automatic classification of patients with Alzheimer’s disease from structural MRI: a comparison of ten methods using the ADNI database. Neuroimage 56:766–781

    Google Scholar 

  97. Davatzikos C, Bhatt P, Shaw LM, Batmanghelich KN, Trojanowski JQ (2011) Prediction of MCI to AD conversion, via MRI, CSF biomarkers. Pattern classification. Neurobiol Aging 32(12):2322.e19-2322.e27

    Google Scholar 

  98. Engedal K, Barca ML, Høgh P, Bo Andersen B, Dombernowsky NW, Naik M, Gudmundsson TE, ksengaard AR, Wahlund LO, Snaedal J (2020) The power of EEG to predict conversion from mild cognitive impairment and subjective cognitive decline to dementia. Dement Geriatr Cogn Disord 49:38–47

    Google Scholar 

  99. Grassi M, Rouleaux N, Caldirola D, Loewenstein D, Schruers K, Perna G, Dumontier M (2019) Alzheimer’s disease neuroimaging initiative a novel ensemble-based machine learning algorithm to predict the conversion from mild cognitive impairment to Alzheimer’s disease using socio-demographic characteristics, clinical information, and neuropsychological measures. Front Neurol 10:756

    Google Scholar 

  100. Lee G, Nho K, Kang B, Sohn KA, Kim D. (2019) Predicting Alzheimer’s disease progression using multi-modal deep learning approach. Sci Rep. 9

  101. Lin,W, Gao Q, Yuan J, Chen Z, Feng C, Chen W, Du M, Tong T (2020) Predicting Alzheimer’s disease conversion from mild cognitive impairment using an extreme learning machine-based grading method with multimodal data. Front Aging Neurosci 12

  102. Liu S, Liu S, Cai W, Che H, Pujol S, Kikinis R, Feng D, Fulham MJ (2015) ADNI multimodal neuroimaging feature learning for multiclass diagnosis of Alzheimer’s disease. IEEE Trans Biomed Eng 62:1132–1140

    Google Scholar 

  103. Moradi E, Pepe A, Gaser C, Huttunen H, Tohka J (2015) Machine learning framework for early MRI-based Alzheimer’s conversion prediction in MCI subjects. Neuroimage 104:398–412

    Google Scholar 

  104. Pan D, Zeng A, Jia L, Huang Y, Frizzell T, Song X (2020) Early detection of Alzheimer’s disease using magnetic resonance imaging: a novel approach combining convolutional neural networks and ensemble learning. Front Neurosci 14:259

    Google Scholar 

  105. Platero C,Tobar MC (2020) Alzheimer’s disease neuroimaging initiative predicting Alzheimer’s conversion in mild cognitive impairment patients using longitudinal neuroimaging and clinical markers. Brain Imaging Behav

  106. Popescu SG, Whittington A, Gunn RN, Matthews PM, Glocker B, Sharp DJ, Cole JH (2020) Alzheimer’s disease neuroimaging initiative nonlinear biomarker interactions in conversion from mild cognitive impairment to Alzheimer’s disease Hum Brain Mapp

  107. Pusil S, Dimitriadis SI, López ME, Pereda E, Maestú F (2019) Aberrant MEG multi-frequency phase temporal synchronization predicts conversion from mild cognitive impairment-to-Alzheimer’s disease. Neuroimage Clin 24:101972

    Google Scholar 

  108. Tong T, Gao Q, Guerrero R, Ledig C, Chen L, Rueckert D (2017) A novel grading biomarker for the prediction of conversion from mild cognitive impairment to Alzheimer’s disease. IEEE Trans Biomed Eng 64:155–165

    Google Scholar 

  109. Yan Y, Somer E, Grau V (2019) Classification of amyloid PET images using novel features for early diagnosis of Alzheimer’s disease and mild cognitive impairment conversion. Nucl Med Commun 40:242–248

    Google Scholar 

  110. Petersen RC (2018) How early can we diagnose Alzheimer disease (and is it sufficient)? The 2017 Wartenberg Lecture. Neurology 91:395–402

    Google Scholar 

  111. Grundman M, Petersen RC, Ferris SH, Thomas RG, Aisen PS, Bennett DA, Foster NL, Jack CR, Galasko DR, Doody R et al (2004) Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials. Arch Neurol 61:59–66

    Google Scholar 

  112. Kohannim O, Hua X, Hibar DP, Lee S, Chou Y-Y, Toga AW, Jack CR Jr, Weiner MW, Thompson PM (2010) Boosting power for clinical trials using classifiers based on multiple biomarkers. Neurobiol Aging 31:1429–1442

    Google Scholar 

  113. Walhovd KB, Fjell AM, Brewer J, McEvoy LK, Fennema-Notestine C, Hagler DJ, Jennings RG, Karow D, Dale AM (2010) Combining MR imaging, positron-emission tomography, and CSF biomarkers in the diagnosis and prognosis of Alzheimer disease. Am J Neuroradiol 31:347–354

    Google Scholar 

  114. Westman E, Muehlboeck J-S, Simmons A (2012) Combining MRI and CSF measures for classification of Alzheimer’s disease and prediction of mild cognitive impairment conversion. Neuroimage 62:229–238

    Google Scholar 

  115. Gao J, Li P, Chen Z, Zhang J (2020) A survey on deep learning for multimodal data fusion. Neural Comput 32:829–864

    MathSciNet  Google Scholar 

  116. El-Sappagh S, Alonso JM, Islam SMR, Sultan AM, Kwak KS (2021) A multilayer multimodal detection and prediction model based on explainable artificial intelligence for Alzheimer’s disease. Sci Rep 11:2660

    Google Scholar 

  117. De Simone MS, De Tollis M, Fadda L, Perri R, Caltagirone C, Carlesimo GA (2020) Lost or unavailable? Exploring mechanisms that affect retrograde memory in mild cognitive impairment and Alzheimer’s disease patients. J Neurol 267:113–124

    Google Scholar 

  118. De Simone MS, Perri R, Fadda L, De Tollis M, Turchetta CS, Caltagirone C, Carlesimo GA (2017) Different deficit patterns on word lists and short stories predict conversion to Alzheimer’s disease in patients with amnestic mild cognitive impairment. J Neurol 264:2258–2267

    Google Scholar 

  119. De Simone MS, Perri R, Fadda L, Caltagirone C, Carlesimo GA (2019) Predicting progression to Alzheimer’s disease in subjects with amnestic mild cognitive impairment using performance on recall and recognition tests. J Neurol 266:102–111

    Google Scholar 

  120. Di Lorenzo F, Motta C, Casula EP, Bonnì S, Assogna M, Caltagirone C, Martorana A, Koch G (2020) LTP-like cortical plasticity predicts conversion to dementia in patients with memory impairment. Brain Stimul 13:1175–1182

    Google Scholar 

  121. Giorgio J, Landau SM, Jagust WJ, Tino P, Kourtzi Z (2020) Alzheimer’s disease neuroimaging initiative modelling prognostic trajectories of cognitive decline due to Alzheimer’s disease. Neuroimage Clin 26:102199

    Google Scholar 

  122. Thung K-H, Yap P-T, Adeli E, Lee S-W, Shen D (2018) Conversion and time-to-conversion predictions of mild cognitive impairment using low-rank affinity pursuit denoising and matrix completion. Med Image Anal 45:68–82

    Google Scholar 

  123. Cox DR (1992) Regression models and lifetables. Breakthroughs in statistics R Stat Soc 372:527–541

    Google Scholar 

  124. Cox, D.R.; Oakes, D. Analysis of survival data; CRC Press: Boca Raton, FL, USA, 1984; Volume 21, ISBN 0–412–24490-X

  125. Liu K, Chen K, Yao L, Guo X. (2017) Prediction of mild cognitive impairment conversion using a combination of independent component analysis, and the cox model. Front Hum Neurosci 11

  126. Li S, Okonkwo O, Albert M, Wang M-C (2013) Variation in variables that predict progression from MCI to AD dementia over duration of follow-up. Am J Alzheimer’s Dis 2:12–28

    Google Scholar 

  127. Franzmeier N, Koutsouleris N, Benzinger T, Goate A, Karch CM, Fagan AM, McDade E, Duering M, Dichgans M, Levin J et al (2020) Predicting sporadic Alzheimer’s disease progression via inherited Alzheimer’s disease-informed machine-learning. Alzheimer’s Dement 16:501–511

    Google Scholar 

  128. Langa KM, Levine DA (2014) The diagnosis and management of mild cognitive impairment: a clinical review. JAMA 312:2551–2561

    Google Scholar 

  129. Rosenberg PB, Lyketsos C (2008) Mild cognitive impairment: searching for the prodrome of Alzheimer’s disease. World Psychiatry 7:72–78

    Google Scholar 

  130. Gamberger D, Lavraˇc N, Srivatsa S, Tanzi RE, Doraiswamy PM. (2017) Identification of clusters of rapid and slow decliners among subjects at risk for Alzheimer’s disease Sci Rep. 7

  131. Gamberger D, Ženko B, Mitelpunkt A, Lavraˇc N. (2016) Homogeneous clusters of Alzheimer’s disease patient population. Biomed Eng Online 15

  132. Mitelpunkt A, Galili T, Kozlovski T, Bregman N, Shachar N, Markus-Kalish M, Benjamini Y (2020) Novel Alzheimer’s disease subtypes identified using a data and knowledge driven strategy. Sci Rep 10:1327

    Google Scholar 

  133. Young AL, Marinescu RV, Oxtoby NP, Bocchetta M, Yong K, Firth NC, Cash DM, Thomas DL, Dick KM, Cardoso J et al. (2018) Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with subtype and stage inference. Nat Commun 9

  134. Hampel H, Vergallo A, Perry G, Lista S (2019) Alzheimer precision medicine initiative. The Alzheimer precision medicine initiative. J Alzheimer’s Dis 68:1–24

    Google Scholar 

  135. Forloni G (2020) Alzheimer’s disease: from basic science to precision medicine approach. BMJ Neurol Open 2:e000079

    Google Scholar 

  136. Hampel H, Nisticò R, Seyfried NT, Levey AI, Modeste E, Lemercier P, Baldacci F, Toschi N, Garaci F, Perry G et al (2021) Omics sciences for systems biology in Alzheimer’s disease: State-of-the-art of the evidence. Ageing Res Rev 69:101346

    Google Scholar 

  137. Neff RA, Wang M, Vatansever, S, Guo L, Ming C, Wang Q, Wang E, Horgusluoglu-Moloch E, Song WM, Li A et al. (2021) Molecular subtyping of Alzheimer’s disease using RNA sequencing data reveals novel mechanisms and targets. Sci. Adv.7

  138. Wolpert DH, Macready WG (1997) No free lunch theorems for optimization. IEEE Trans Evol Comput 1:67–82

    Google Scholar 

  139. Waring J, Lindvall C, Umeton R (2020) Automated machine learning: Review of the state-of-the-art and opportunities for healthcare. Artif Intell Med 104:101822

    Google Scholar 

  140. Wirth R, Hipp J. (2000) CRISP-DM: towards a standard process model for data mining. In proceedings of the 4th international conference on the practical applications of knowledge discovery and data mining, Manchester, UK, 11–13

  141. Vougas K, Sakellaropoulos T, Kotsinas A, Foukas G-RP, Ntargaras A, Koinis F, Polyzos A, Myrianthopoulos V, Zhou H, Narang S (2019) Machine learning and data mining frameworks for predicting drug response in cancer: An overview and a novel in silico screening process based on association rule mining. Pharmacol Ther 203:107395

    Google Scholar 

  142. Gu, Ke & Xia, Zhifang & Qiao, Junfei & Lin, Weisi. (2019). Deep dual-channel neural network for image-based smoke detection. IEEE Transactions on Multimedia. 1–1. https://doi.org/10.1109/TMM.2019.2929009.

  143. Gu K, Xia Z, Qiao J (2020) Stacked selective ensemble for PM2.5 forecast. IEEE Trans Instrum Meas 69(3):660–671. https://doi.org/10.1109/TIM.2019.2905904

    Article  Google Scholar 

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Acknowledgements

This work was carried out as part of a funded project from Vision Group on Science and Technology (VGST), India with GRD number: 880.

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Aditya Shastry, K., Sanjay, H.A. Artificial Intelligence Techniques for the effective diagnosis of Alzheimer’s Disease: A Review. Multimed Tools Appl 83, 40057–40092 (2024). https://doi.org/10.1007/s11042-023-16928-z

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