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Review article epithelial to mesenchymal transition‑associated microRNAs in breast cancer

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Abstract

Despite major advances, breast cancer (BC) is the most commonly diagnosed carcinoma and remains a deadly disease among women worldwide. Many researchers point toward an important role of an epithelial to mesenchymal transition (EMT) in BC development and promoting metastasis. Here, will be discussed that how functional changes of transcription factors, signaling pathways, and microRNAs (miRNA) in BC promote EMT. A thorough understanding the EMT biology can be important to determine reversing the process and design treatment approaches. There are frequent debates as to whether EMT is really relevant to BC in vivo, in which due to the intrinsic heterogeneity and tumor microenvironment. Nevertheless, given the importance of EMT in cancer progression and metastasis, the implementation of therapies against cancer-associated EMT will continue to help us develop and test potential treatments.

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Authors and Affiliations

  1. Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

    Hossein Javdani

  2. Department of Biology, Faculty of Sciences, University of Birjand, Birjand, Iran

    Homa Mollaei

  3. Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran

    Farzaneh Karimi

  4. Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

    Shiva Mahmoudi

  5. Student Research Committee, Department of Molecular Medicine, Birjand University of Medical Sciences, Birjand, Iran

    Ali Farahi

  6. Cell Therapy and Regenerative Medicine Comprehensive Center, Kerman University of Medical Sciences, Kerman, Iran

    Mohamad Javad Mirzaei-Parsa & Arman Shahabi

  7. Research Center for Hydatid Disease in Iran, Kerman University of Medical Sciences, P. O. Box: 7618747653, Kerman, Iran

    Arman Shahabi

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  1. Hossein Javdani
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Javdani, H., Mollaei, H., Karimi, F. et al. Review article epithelial to mesenchymal transition‑associated microRNAs in breast cancer. Mol Biol Rep 49, 9963–9973 (2022). https://doi.org/10.1007/s11033-022-07553-4

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