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Design, construction and mechanical testing of digital 3D anatomical data-based PCL–HA bone tissue engineering scaffold

  • Biomaterials Synthesis and Characterization
  • Published:
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Abstract

The study aims to investigate the techniques of design and construction of CT 3D reconstructional data-based polycaprolactone (PCL)–hydroxyapatite (HA) scaffold. Femoral and lumbar spinal specimens of eight male New Zealand white rabbits were performed CT and laser scanning data-based 3D printing scaffold processing using PCL–HA powder. Each group was performed eight scaffolds. The CAD-based 3D printed porous cylindrical stents were 16 piece × 3 groups, including the orthogonal scaffold, the Pozi-hole scaffold and the triangular hole scaffold. The gross forms, fiber scaffold diameters and porosities of the scaffolds were measured, and the mechanical testing was performed towards eight pieces of the three kinds of cylindrical scaffolds, respectively. The loading force, deformation, maximum-affordable pressure and deformation value were recorded. The pore-connection rate of each scaffold was 100 % within each group, there was no significant difference in the gross parameters and micro-structural parameters of each scaffold when compared with the design values (P > 0.05). There was no significant difference in the loading force, deformation and deformation value under the maximum-affordable pressure of the three different cylinder scaffolds when the load was above 320 N. The combination of CT and CAD reverse technology could accomplish the design and manufacturing of complex bone tissue engineering scaffolds, with no significant difference in the impacts of the microstructures towards the physical properties of different porous scaffolds under large load.

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Authors and Affiliations

  1. Department of Orthopaedics, Nanjing Medical University Nanjing Hospital, Nanjing, 210006, China

    Qingqiang Yao, Bo Wei, Yang Guo, Chengzhe Jin, Xiaotao Du, Chao Yan, Junwei Yan, Wenhao Hu, Yan Xu & Liming Wang

  2. Department of Biological Engineering and Technology, Nanjing University of Technology, Nanjing, 210009, China

    Zhi Zhou

  3. Department of Mechanics, Shanghai University, Shanghai, 201800, China

    Yijin Wang

Authors
  1. Qingqiang Yao
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  2. Bo Wei
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  3. Yang Guo
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  4. Chengzhe Jin
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Correspondence to Liming Wang.

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Yao, Q., Wei, B., Guo, Y. et al. Design, construction and mechanical testing of digital 3D anatomical data-based PCL–HA bone tissue engineering scaffold. J Mater Sci: Mater Med 26, 51 (2015). https://doi.org/10.1007/s10856-014-5360-8

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  • DOI: https://doi.org/10.1007/s10856-014-5360-8

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