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Fabrication of calcium phosphate-calcium sulfate injectable bone substitute using chitosan and citric acid

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Abstract

In this study, an injectable bone substitute (IBS) consisting of citric acid, chitosan solution as the liquid phase and tetra calcium phosphate (TTCP), dicalcium phosphate anhydrous (DCPA) and calcium sulfate hemihydrate (CSH) powders as the solid phase was prepared. Four groups containing different percentages (0–30%) of calcium sulfate hemihydrate (CSH, CaSO4 · 0.5H2O) were investigated. Initial setting times for IBS with CSH were longer than those without CSH. The setting times for all compositions were in the range of 25–45 min. The injectability was improved by the addition of CSH in the present system. Scanning electron microscopy images showed that fiber-like crystallization appeared in the cements. The enhancement of crystallinity was confirmed by XRD profiles where the peak intensity of HAp increased with incubation time and the addition of CSH. Also, the compressive strength increased with the addition of CSH. The maximum compressive strength obtained for IBS was with 20% CSH after 28-day incubation in 100% humidity at 37°C.

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References

  1. R.Z. Legeros, Clin. Mater. 14, 65 (1993)

    Article  PubMed  CAS  Google Scholar 

  2. R.C. Thomson, M.J. Yaszemski, J.M. Powers, A.G. Mikos, Biomaterials 19, 1935 (1998)

    Article  PubMed  CAS  Google Scholar 

  3. L.L. Hench, Biomaterials 19, 1419 (1998)

    Article  PubMed  CAS  Google Scholar 

  4. W. Suchanek, M. Yoshimura, J. Mater. Res. 13, 94 (1998)

    Article  CAS  Google Scholar 

  5. P. Ducheyne, Q. Qiu, Biomaterials 20, 2287 (1999)

    Article  PubMed  CAS  Google Scholar 

  6. C.T. Laurencin, A.M.A. Ambrosip, M.D. Borden, J.A. Cooper Jr, Annu. Rev. Biomed. Eng. 19, 19 (1999)

    Article  Google Scholar 

  7. J.R. Hupp, S. Mckenna, J. Oral Maxillofac. Surg. 46, 538 (1988)

    Article  PubMed  CAS  Google Scholar 

  8. A.R.M. Wittkmpf, J. Oral Maxillofac. Surg. 46, 1019 (1988)

    Article  Google Scholar 

  9. W.E. Brown, L.C. Chow, Cements Research Progress (American Ceramic Society, Westerville, OH, 1986), pp. 352–379

    Google Scholar 

  10. L.C. Chow, Mater. Res. Symp. Proc. 599, 27 (2000)

    CAS  Google Scholar 

  11. W.E. Brown, L.C. Chow, US Patent 4,612,053, 1986

  12. Y.C. Hong, J.T. Wang, C.Y. Hong, W.E. Brown, L.C. Chow, J. Biomed. Mater. Res. 25, 485 (1991)

    Article  PubMed  CAS  Google Scholar 

  13. A. Sugawara, M. Nishiyama, K. Kusama, I. Moro, S. Nishinura, I. Kudo, L.C. Chow, S. Takagi, Dent. Mater. J. 11, 11 (1992)

    PubMed  CAS  Google Scholar 

  14. Y. Machida, T. Nagai, M. Abe, T. Sannan, Drug Discov. Deliv. 1, 119 (1986)

    CAS  Google Scholar 

  15. R.A.A. Muzzarelli, G. Biagini, M. Bellardini, L. Simonelli, C. Castaldini, G. Fratto, Biomaterials 14, 39 (1993)

    Article  PubMed  CAS  Google Scholar 

  16. M. Takechi, Y. Miyamoto, K. Ishikawa, T. Toh, T. Yuasa, M. Nagayama, Biomaterials 19, 2057 (1998)

    Article  PubMed  CAS  Google Scholar 

  17. Y. Zhang, M. Zhang, J. Biomed. Mater. Res. 55, 304 (2001)

    Article  PubMed  ADS  CAS  Google Scholar 

  18. L.F. Peltier, R.H. Jones, J. Bone, Joint Surg. A 60, 820 (1978)

    CAS  Google Scholar 

  19. D. Stubbs, M. Deakin, P. Chapman-Sheath, W. Bruce, J. Debes, R.M. Gillies, Biomaterials 25, 5037 (2004)

    Article  PubMed  CAS  Google Scholar 

  20. J.C. Doadrio, D. Acros, M.V. Cabañas, M. Vallet-Regí, Biomaterials 25, 2629 (2004)

    Article  PubMed  CAS  Google Scholar 

  21. S.M. Kenny, M. Buggy, J. Mater. Sci. Mater. Med. 14, 923 (2003)

    Article  PubMed  CAS  Google Scholar 

  22. M.V. Cabañas, L.M. Rodríguez-Lorenzo, M. Vallet-Regí, Chem. Mater. 14, 3550 (2002)

    Article  Google Scholar 

  23. A. Jamali, A. Hilpert, J. Debes, P. Afshar, S. Rahban, R. Holmes, Calcif. Tissue Int. 71, 172 (2002)

    Article  PubMed  CAS  Google Scholar 

  24. E. Fernández, M.D. Vlad, M.M. Gel, J. López, R. Torrs, J.V. Cauich, M. Bohner, Biomaterials 26, 3395 (2005)

    Article  PubMed  Google Scholar 

  25. ISO 9917-1, Dentistry-Water-Based Cements—Part 1: Powder/Liquid Acid-Base Cements (ISO, Geneva, Switzerland, 2003)

    Google Scholar 

  26. M. Bohner, Biomaterials 25, 741 (2004)

    Article  PubMed  CAS  Google Scholar 

  27. I. Khairoun, M.G. Boltong, F.C.M. Driessens, J.A. Planell, J. Mater. Sci. Mater. Med. 9, 425 (1998)

    Article  PubMed  CAS  Google Scholar 

  28. M. Bohner, G. Baroud, Biomaterials 13, 1553 (2005)

    Article  Google Scholar 

Download references

Acknowledgement

This work was supported by a grant from the Center for Advanced Materials Processing (CAMP) of the 21st Century Frontier R&D Program funded by the Ministry of Commerce, Industry and Energy (MOCIE), Republic of Korea.

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Authors and Affiliations

  1. Department of Microbiology, School of Medicine, Soonchunhyang University, 366-1 Ssangyoung-dong, Cheonan City, Chungnam, 330-090, South Korea

    Ho-Yeon Song

  2. Department of Biomedical Engineering and Materials, School of Medicine, Soonchunhyang University, 366-1 Ssangyoung-dong, Cheonan City, Chungnam, 330-090, South Korea

    A. H. M. Esfakur Rahman & Byong-Taek Lee

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  1. Ho-Yeon Song
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  2. A. H. M. Esfakur Rahman
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  3. Byong-Taek Lee
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Correspondence to Byong-Taek Lee.

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Song, HY., Esfakur Rahman, A.H.M. & Lee, BT. Fabrication of calcium phosphate-calcium sulfate injectable bone substitute using chitosan and citric acid. J Mater Sci: Mater Med 20, 935–941 (2009). https://doi.org/10.1007/s10856-008-3642-8

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  • DOI: https://doi.org/10.1007/s10856-008-3642-8

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