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Pre-implantation genetic testing: decisional factors to accept or decline among in vitro fertilization patients

  • Genetics
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

Embryo testing to improve pregnancy outcomes among individuals who are seeking assisted reproduction technologies is increasing. The purpose of this study was to assess decisional factors through in-depth interviews for why women would accept or decline preimplantation genetic testing for aneuploidy (PGT-A) with in vitro fertilization (IVF).

Methods

Semi-structured telephone interviews were conducted with 37 women who were offered PGT-A with IVF during the summer 2017. Interviews lasted on average 40 min and were audio-recorded, transcribed, and analyzed using a content analysis.

Results

Results identified a number of decisional factors related to values about conception, disability, and pregnancy termination, past pregnancy experiences, optimism toward technology, and cost. Other key issues that were identified include the use of expanded carrier screening prior to IVF, maternal age, and limited education about PGT-A due to the complexity about education for IVF alone.

Conclusion

There is a need to develop decision support tools for the increasing choices of genetic testing options for patients seeking IVF. Including patients’ values, past pregnancy experiences and attitudes toward science into the decision-making process may help promote a more informed decision.

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Acknowledgements

The authors would like to thank the University of Utah Graduate Program in Genetic Counseling and the Creative Research Grant program for their support for this research. We would like to thank the Utah Center in Excellence in Ethical, Legal and Social Implications (HG009037) and the Center for Clinical and Translational Science program (1UL1TR001067) for their partial support.

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Authors and Affiliations

  1. University of Utah, 10 South 2000 East, Salt Lake City, UT, USA

    Brandy Lamb, Erin Johnson, Leslie Francis, Melinda Fagan, Naomi Riches, Isabella Canada, Alena Wilson, Amber Mathiesen, Erica Johnstone & Erin Rothwell

  2. Columbia University, New York, NY, USA

    Maya Sabatello

  3. Utah Fertility Clinic, Pleasant Grove, UT, USA

    Shawn Gurtcheff

Authors
  1. Brandy Lamb
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  2. Erin Johnson
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  3. Leslie Francis
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Correspondence to Erin Rothwell.

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The authors declare that they have no conflict of interest.

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Lamb, B., Johnson, E., Francis, L. et al. Pre-implantation genetic testing: decisional factors to accept or decline among in vitro fertilization patients. J Assist Reprod Genet 35, 1605–1612 (2018). https://doi.org/10.1007/s10815-018-1278-2

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  • DOI: https://doi.org/10.1007/s10815-018-1278-2

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