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Macrophages Generate Pericytes in the Developing Brain

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Abstract

Pericytes are defined by their anatomical location encircling blood vessels' walls with their long projections. The exact embryonic sources of cerebral pericytes remain poorly understood, especially because of their recently revealed diversity. Yamamoto et al. (Sci Rep 7(1):3855, 2017) using state-of-the-art techniques, including several transgenic mice models, reveal that a subpopulation of brain pericytes are derived from phagocytic macrophages during vascular development. This work highlights a new possible ancestor of brain pericytes. The emerging knowledge from this research may provide new approaches for the treatment of several neurodevelopmental disorders in the future.

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Acknowledgements

Alexander Birbrair is supported by a grant from Pró-reitoria de Pesquisa/Universidade Federal de Minas Gerais (PRPq/UFMG) (Edital 05/2016); Akiva Mintz is supported by the National Institute of Health (1R01CA179072-01A1) and by the American Cancer Society Mentored Research Scholar Grant (124443-MRSG-13-121-01-CDD).

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Authors and Affiliations

  1. Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil

    Pedro H. D. M. Prazeres, Viviani M. Almeida, Luiza Lousado, Julia P. Andreotti, Ana E. Paiva, Gabryella S. P. Santos, Patrick O. Azevedo, Luanny Souto, Gregório G. Almeida, Ricardo Gonçalves & Alexander Birbrair

  2. Laboratory of Neurobiology, Federal University of São Paulo, São Paulo, SP, Brazil

    Renato Filev

  3. Department of Radiology, Columbia University Medical Center, New York, NY, USA

    Akiva Mintz

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Contributions

PHDMP, AEP, VMA, LL, JPA, and AB elaborated the figure. PHDMP, VMA, LL, JPA, AEP, GSPS, POA, LS, GGA, RF, AM, RG, and AB wrote the manuscript. All of the authors discussed the results in Yamamoto et al. (2017) and commented on the manuscript.

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Correspondence to Alexander Birbrair.

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Prazeres, P.H.D.M., Almeida, V.M., Lousado, L. et al. Macrophages Generate Pericytes in the Developing Brain. Cell Mol Neurobiol 38, 777–782 (2018). https://doi.org/10.1007/s10571-017-0549-2

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