[go: up one dir, main page]
More Web Proxy on the site http://driver.im/ Skip to main content

Advertisement

Springer Nature Link
Log in

MIR146A rs2910164 (G/C) Polymorphism is Associated with Incidence of Preeclampsia in Gestational Diabetes Patients

  • Original Article
  • Published:
Biochemical Genetics Aims and scope Submit manuscript

Abstract

Preeclampsia and gestational diabetes are common pregnancy disorders that may be interrelated. MIR146A rs2910164 (G/C) is a functional polymorphism that was associated with several diseases. This study aimed to investigate the frequency of rs2910164 polymorphism and its possible correlation with the incidence of preeclampsia in gestational diabetes patients. The study involved 250 pregnant women divided into 80 healthy control subjects, 85 gestational diabetes patients only, and 85 patients of gestational diabetes combined with preeclampsia. Systolic and diastolic blood pressures, urinary proteins, kidney and liver functions, glucose homeostasis parameters, and lipid profile were determined. Genotyping of the polymorphism was conducted by PCR-RFLP. The frequency of the minor C allele of rs2910164 polymorphism was significantly higher among patients of gestational diabetes combined with preeclampsia compared to the control group (p = 0.012) and the gestational diabetes group (p = 0.014). Patients of gestational diabetes and preeclampsia carrying CC genotype showed higher systolic and diastolic blood pressure, and increased urea, creatinine, urine protein, and dyslipidemia compared to the carriers of GG and GC genotypes. In conclusion, the results of the current study suggest that the rare CC genotype of MIR146A rs2910164 (G/C) polymorphism may be related to increased incidence of preeclampsia in gestational diabetes patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
£29.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (United Kingdom)

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  • American Diabetes Association (2017) Classification and diagnosis of diabetes mellitus. Diabetes Care 40(Suppl 1):S11–S24

    Article  Google Scholar 

  • Assman TS, Giudice VM, Lima JR, Duarte GCK, Canani LH, Crispim D (2015) RS2910164 polymorphism in the microrna-146a is associated with risk for type 1 diabetes mellitus. Diabetol Metab Syndr 7(Suppl 1):A205

    Article  Google Scholar 

  • Bhatt K, Lanting LL, Jia Y, Yadav S, Reddy MA, Magilnick N, Boldin M, Natarajan R (2016) Anti-inflammatory role of MicroRNA-146a in the pathogenesis of diabetic nephropathy. J Am Soc Nephrol 27(8):2277–2288

    Article  CAS  PubMed  Google Scholar 

  • Bryson CL (2003) Association between gestational diabetes and pregnancy-induced hypertension. Am J Epidemiol 158(12):1148–1153

    Article  PubMed  Google Scholar 

  • Chen DB, Wang W (2013) Human placental microRNAs and preeclampsia. Biol Reprod 88(5):130

    Article  PubMed  PubMed Central  Google Scholar 

  • Chiofalo B, Laganà AS, Vaiarelli A, La Rosa VL, Rossetti D, Palmara V, Valenti G, Rapisarda AMC, Granese R, Sapia F, Triolo O, Vitale SG (2017) Do miRNAs play a role in fetal growth restriction? A fresh look to a busy corner. Biomed Res Int 2017:6073167

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Cornelis T, Odutayo A, Keunen J, Hladunewich M (2011) The kidney in normal pregnancy and preeclampsia. Semin Nephrol 31(1):4–14

    Article  CAS  PubMed  Google Scholar 

  • Dai Y, Jia P, Fang Y, Liu H, Jiao X, He JC, Ding X (2016) miR-146a is essential for lipopolysaccharide (LPS)-induced cross-tolerance against kidney ischemia/reperfusion injury in mice. Sci Rep 6:27091

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Desir GV (2011) Role of renalase in the regulation of blood pressure and the renal dopamine system. Curr Opin Nephrol Hypertens 20(1):31–36

    Article  CAS  PubMed  Google Scholar 

  • Devier DJ, Lovera JF, Lukiw W (2015) Increase in NF-κB-sensitive miRNA-146a and miRNA-155 in multiple sclerosis (MS) and pro-inflammatory neurodegeneration. Front Mol Neurosci 8:5

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Dziedzic M, Powrózek T, Orłowska E, Koch W, Kukula-Koch W, Gaweł K, Bednarek-Skublewska A, Małecka-Massalska T, Milanowski J, Petkowicz B, Solski J (2017) Relationship between microRNA-146a expression and plasma renalase levels in hemodialyzed patients. PLoS ONE 12(6):e0179218

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • English FA, Kenny LC, McCarthy FP (2015) Risk factors and effective management of preeclampsia. Integr Blood Press Control 8:7–12

    PubMed  PubMed Central  Google Scholar 

  • Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18(6):499–502

    CAS  PubMed  Google Scholar 

  • Girling JC, Dow E, Smith JH (1997) Liver function tests in pre-eclampsia: importance of comparison with a reference range derived for normal pregnancy. Br J Obstet Gynaecol 104(2):246–250

    Article  CAS  PubMed  Google Scholar 

  • Gohil JT, Patel PK, Gupta P (2011) Estimation of lipid profile in subjects of preeclampsia. J Obstet Gynaecol India 61(4):399–403

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gomez-Lira M, Ferronato S, Orlandi E, Dal Molin A, Malerba G, Frigerio S, Rodolfo M, Romanelli MG (2015) Association of microRNA 146a polymorphism rs2910164 and the risk of melanoma in an Italian population. Exp Dermatol 24(10):794–795

    Article  PubMed  Google Scholar 

  • Jensen LA, Chik CL, Ryan EA (2016) Review of gestational diabetes mellitus effects on vascular structure and function. Diabetes Vasc Dis Res 13(3):170–182

    Article  CAS  Google Scholar 

  • Koivusalo SB, Rönö K, Klemetti MM, Roine RP, Lindström J, Erkkola M, Kaaja RJ, Pöyhönen-Alho M, Tiitinen A, Huvinen E, Andersson S, Laivuori H, Valkama A, Meinilä J, Kautiainen H, Eriksson JG, Stach-Lempinen B (2016) Gestational Diabetes mellitus can be prevented by lifestyle intervention: the Finnish Gestational Diabetes Prevention Study (RADIEL): a randomized controlled trial. Diabetes Care 39(1):24–30

    Article  CAS  PubMed  Google Scholar 

  • Laganà AS, Giordano D, Loddo S, Zoccali G, Vitale SG, Santamaria A, Buemi M, D’Anna R (2017) Decreased Endothelial Progenitor Cells (EPCs) and increased Natural Killer (NK) cells in peripheral blood as possible early markers of preeclampsia: a case–control analysis. Arch Gynecol Obstet 295(4):867–872

    Article  PubMed  CAS  Google Scholar 

  • Laganà AS, Vitale SG, Sapia F, Valenti G, Corrado F, Padula F, Rapisarda AMC, D’Anna R (2018) miRNA expression for early diagnosis of preeclampsia onset: hope or hype? J Matern Fetal Neonatal Med 31(6):817–821

    Article  PubMed  CAS  Google Scholar 

  • Lee J, Ouh YT, Ahn KH, Hong SC, Oh MJ, Kim HJ, Cho GJ (2017) Preeclampsia: a risk factor for gestational diabetes mellitus in subsequent pregnancy. PLoS ONE 12(5):e0178150

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Li XL, Chen TT, Dong X, Gou WL, Lau S, Stone P, Chen Q (2014) Early onset preeclampsia in subsequent pregnancies correlates with early onset preeclampsia in first pregnancy. Eur J Obstet Gynecol Reprod Biol 177:94–99

    Article  CAS  PubMed  Google Scholar 

  • Mackay AP, Berg CJ, Atrash HK (2001) Pregnancy-related mortality from preeclampsia and eclampsia. Obstet Gynecol 97:533–538

    CAS  PubMed  Google Scholar 

  • Maharaj NR, Ramkaran P, Pillay S, Chuturgoon AA (2017) MicroRNA-146a rs2910164 is associated with severe preeclampsia in Black South African women on HAART. BMC Genet 18(1):5

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28(7):412–419

    Article  CAS  PubMed  Google Scholar 

  • Maynard SE, Min JY, Merchan J, Lim KH, Li J, Mondal S, Libermann TA, Morgan JP, Sellke FW, Stillman IE, Epstein FH, Sukhatme VP, Karumanchi SA (2003) Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 111(5):649–658

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mehanna ET, Ghattas MH, Mesbah NM, Saleh SM, Abo-Elmatty DM (2015) Association of microRNA-146a rs2910164 gene polymorphism with metabolic syndrome. Folia Biol (Praha) 61(1):43–48

    CAS  Google Scholar 

  • Moran P, Lindheimer MD, Davison JM (2004) The renal response to preeclampsia. Semin Nephrol 24(6):588–595

    Article  PubMed  Google Scholar 

  • Munazza B, Raza N, Naureen A, Khan SA, Fatima F, Ayub M, Sulaman M (2011) Liver function tests in preeclampsia. J Ayub Med Coll Abbottabad 23(4):3–5

    PubMed  Google Scholar 

  • Ostlund I, Haglund B, Hanson U (2004) Gestational diabetes and preeclampsia. Eur J Obstet Gynecol Reprod Biol 113(1):12–16

    Article  PubMed  Google Scholar 

  • Paterson MR, Kriegel AJ (2017) MiR-146a/b: a family with shared seeds and different roots. Physiol Genom 49(4):243–252

    Article  CAS  Google Scholar 

  • Qu JY, Xi J, Zhang YH, Zhang CN, Song L, Song Y, Hui RT, Chen JZ (2016) Association of the microRNA-146a SNP rs2910164 with ischemic stroke incidence and prognosis in a Chinese Population. Int J Mol Sci 17(5):660

    Article  PubMed Central  CAS  Google Scholar 

  • Ramkaran P, Khan S, Phulukdaree A, Moodley D, Chuturgoon AA (2014) MiR-146a polymorphism influences levels of miR-146a, IRAK-1, and TRAF-6 in young patients with coronary artery disease. Cell Biochem Biophys 68:259–266

    Article  CAS  PubMed  Google Scholar 

  • Redman CW, Sargent IL (2005) Latest advances in understanding preeclampsia. Science 308(5728):1592–1594

    Article  CAS  PubMed  Google Scholar 

  • Rong Y, Bao W, Shan Z, Liu J, Yu X, Xia S, Gao H, Wang X, Yao P, Hu FB, Liu L (2013) Increased microRNA-146a levels in plasma of patients with newly diagnosed type 2 diabetes mellitus. PLoS ONE 8(9):e73272

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ryckman KK, Spracklen CN, Smith CJ, Robinson JG, Saftlas AF (2015) Maternal lipid levels during pregnancy and gestational diabetes: a systematic review and meta-analysis. BJOG 122(5):643–651

    Article  CAS  PubMed  Google Scholar 

  • Schneider S, Freerksen N, Röhrig S, Hoeft B, Maul H (2012) Gestational diabetes and preeclampsia—similar risk factor profiles? Early Hum Dev 88(3):179–184

    Article  PubMed  Google Scholar 

  • Siddiqui IA (2014) Maternal serum lipids in women with pre-eclampsia. Ann Med Health Sci Res 4(4):638–641

    Article  PubMed  PubMed Central  Google Scholar 

  • van der Graaf AM, Toering TJ, Faas MM, Lely AT (2012) From preeclampsia to renal disease: a role of angiogenic factors and the renin-angiotensin aldosterone system? Nephrol Dial Transplant 27(Suppl 3):iii51–iii57

    PubMed  Google Scholar 

  • Wagner LK (2004) Diagnosis and management of preeclampsia. Am Fam Physician 70(12):2317–2324

    PubMed  Google Scholar 

  • Weissgerber TL, Mudd LM (2015) Preeclampsia and diabetes. Curr Diabetes Rep 15(3):579

    Article  CAS  Google Scholar 

  • Williams AE, Perry MM, Moschos SA, Larner-Svensson HM, Lindsay MA (2008) Role of miRNA-146a in the regulation of the innate immune response and cancer. Biochem Soc Trans 36(Pt 6):1211–1215

    Article  CAS  PubMed  Google Scholar 

  • Wiznitzer A, Mayer A, Novack V, Sheiner E, Gilutz H, Malhotra A, Novack L (2009) Association of lipid levels during gestation with preeclampsia and gestational diabetes mellitus: a population-based study. Am J Obstet Gynecol 201(5):e1–e8

    Article  CAS  Google Scholar 

  • Xia ZG, Yin HF, Long Y, Cheng L, Yu LJ, Guo WJ, Zhu XD, Li J, Wang YN, Yang YJ, Wang JC, Jin L, Qiu LX, Wei Y (2016) Genetic variant of miR-146a rs2910164 C>G and gastric cancer susceptibility. Oncotarget 7(23):34316–34321

    Article  PubMed  PubMed Central  Google Scholar 

  • Xiang Z, Song J, Zhou X, Li Q, Zhang X (2017) MiR-146a rs2910164 polymorphism and head and neck carcinoma risk: a meta-analysis based on 10 case–control studies. Oncotarget 8(1):1226–1233

    PubMed  Google Scholar 

  • Yang K, He YS, Wang XQ, Lu L, Chen QJ, Liu J, Sun Z, Shen WF (2011) MiR-146a inhibits oxidized low-density lipoprotein-induced lipid accumulation and inflammatory response via targeting toll-like receptor 4. FEBS Lett 585(6):854–860

    Article  CAS  PubMed  Google Scholar 

  • Yogev Y, Langer O, Brustman L, Rosenn B (2004) Pre-eclampsia and gestational diabetes mellitus: does a correlation exist early in pregnancy? J Matern Fetal Neonatal Med 15(1):39–43

    Article  CAS  PubMed  Google Scholar 

  • Zeng Y, Sun Q, Liu N, Dong G, Chen J, Yang L, Wang B (2010) Correlation between pre-miR-146a C/G polymorphism and gastric cancer risk in Chinese population. World J Gastroenterol 16(28):3578–3583

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhang W, Yi X, Guo S, Shi Q, Wei C, Li X, Gao L, Wang G, Gao T, Wang L, Li C (2014) A single-nucleotide polymorphism of miR-146a and psoriasis: an association and functional study. J Cell Mol Med 18(11):2225–2234

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhong H, Cai Y, Cheng J, Cai D, Chen L, Su C, Li K, Chen P, Xu J, Cui L (2016) Apolipoprotein E epsilon 4 enhances the association between the rs2910164 polymorphism of miR-146a and risk of atherosclerotic cerebral infarction. J Atheroscler Thromb 23(7):819–829

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

The authors are thankful to the staff members of the Obstetrics and Gynecology Department in the Suez Canal University Hospital and tha Ismailia General Hospital for their help in the collection of samples.

Funding

The work was funded by the authors.

Author information

Authors and Affiliations

  1. Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt

    Dina M. Abo-Elmatty & Eman T. Mehanna

Authors
  1. Dina M. Abo-Elmatty
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Eman T. Mehanna
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Eman T. Mehanna.

Ethics declarations

Conflict of interest

The authors declare no conflict of interests.

Informed Consent

All the participants in the study provided written informed consent following a protocol approved by the Research Ethics Committee of Faculty of Pharmacy, Suez Canal University (Code: 201709RH1). The study followed the principles of the Declaration of Helsinki.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Abo-Elmatty, D.M., Mehanna, E.T. MIR146A rs2910164 (G/C) Polymorphism is Associated with Incidence of Preeclampsia in Gestational Diabetes Patients. Biochem Genet 57, 222–233 (2019). https://doi.org/10.1007/s10528-018-9886-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10528-018-9886-1

Keywords

Search

Navigation