Effects of blockage of central galanin receptors on anxiety manifestations were studied in rats with psychogenic trauma. Psychogenic trauma was modeled by exposure of a group of rats to the situation when the partner was killed by a predator. Antagonist of galanin receptors was intranasally administered before stress exposure. Animal behavior was evaluated using the elevated-plus maze test, free exploratory paradigm, and open-field test. Psychogenic trauma was followed by an increase in anxiety level and appearance of agitated behavior. Blockageof galanin receptors aggravated behavioral impairment, which manifested in the pathological anxious reactions – manifestations of hypervigilance and hyperawareness. The results suggest that endogenous pool of galanin is involved into prevention of excessive CNS response to stressful stimuli typical of posttraumatic stress disorder.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 159, No. 3, pp. 322-324, March, 2015
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Lyudyno, V.I., Tsikunov, S.G., Abdurasulova, I.N. et al. Modifi cation of Anxious Behavior after Psychogenic Trauma and Treatment with Galanin Receptor Antagonist. Bull Exp Biol Med 159, 344–347 (2015). https://doi.org/10.1007/s10517-015-2958-x
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DOI: https://doi.org/10.1007/s10517-015-2958-x