High levels of macrophages and fibroblasts expressing MMP-2, MMP-9, and MMP-10 against the background of progressing early fibrosis of the lungs (manifesting in an increase in volume density of type I, III, IV, and VI collagens) were found in C57Bl/6 mice infected with influenza A/H5N1 A/goose/Krasnoozerskoye/627/05 virus. Progressing fibrosis of the lungs in infected mice was associated with imbalance of collagen synthesis and degradation processes conjugated with high levels of macrophages and fibroblasts expressing TIMP-2.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 156, No. 7, pp. 17-20, July, 2013
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Anikina, A.G., Potapova, O.V., Shkurupii, V.A. et al. Role of Matrix Metalloproteinases and Their Inhibitor in the Development of Early Pulmonary Fibrosis in Mice Infected with Influenza A/H5N1 A/GOOSE/Krasnoozerskoye/627/05 Virus. Bull Exp Biol Med 156, 11–14 (2013). https://doi.org/10.1007/s10517-013-2265-3
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DOI: https://doi.org/10.1007/s10517-013-2265-3