Silica nanoparticles as carriers for targeted drug delivery to the heart were studied. Studies of hemodynamic parameters of rats after intravenous infusion of silica nanoparticles showed no acute toxicity. Intravenous infusion of silica nanoparticles to animals with ischemia−reperfusion of the myocardium led to accumulation of the nanoparticles in the focus of injury, which attests to possibility of passive targeted drug delivery to the myocardium.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
M. M. Galagudza, D. V. Korolev, D. L. Sonin, et al., Nanotekhnol. Ekol. Proizvodstvo, No. 2, 132–138 (2009).
V. N. Postnov, Nanotechnologies in Biology and Medicine, Ed. E. V. Shlyakhto [in Russian], St. Petersburg (2009), pp. 253–302.
V. N. Postnov, E. B. Kirpicheva, M. M. Galagudza, et al., International Conference “Basic Trends of Chemistry Development at the Beginning of the 21st Century”, Collected Papers [in Russian], St. Petersburg, April 21–24, 2009, St. Petersburg (2009), pp. 181–182.
I. S. Uskov and A. V. Belozertseva, Rusnanotech-09 Second International Forum for Nanotechnologies [in Russian], Moscow, October 6–8, 2009, Moscow (2009), pp. 880–881.
E. V. Shlyakhto, Nanotechnologies in Biology and Medicine, Ed. E. V. Shlyakhto [in Russian], St. Petersburg (2009), pp. 9–60.
S. Ganta, H. Devalapally, A. Shahiwala, and M. Amiji, J. Control. Release, 126, No. 3, 187–204 (2008).
I. I. Slowing, J. L. Vivero-Escoto, C. W. Wu, and V. S. Lin, Adv. Drug Deliv. Rev., 60, No. 11, 1278–1288 (2008).
H. Takahama, T. Minamino, H. Asanuma, et al., J. Am. Coll. Cardiol., 53, No. 8, 709–717 (2009).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 152, No. 7, pp. 113–116, July, 2011
Rights and permissions
About this article
Cite this article
Galagudza, M.M., Korolev, D.V., Sonin, D.L. et al. Passive and Active Target Delivery of Drugs to Ischemic Myocardium. Bull Exp Biol Med 152, 105–107 (2011). https://doi.org/10.1007/s10517-011-1466-x
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-011-1466-x