[go: up one dir, main page]
More Web Proxy on the site http://driver.im/
Skip to main content

Advertisement

Springer Nature Link
Log in

“Set it and Forget it”: Women’s Perceptions and Opinions of Long-Acting Topical Vaginal Gels

  • Original Paper
  • Published:
AIDS and Behavior Aims and scope Submit manuscript

Abstract

Women’s initial understandings and anticipated acceptability of long-acting vaginal gels as potential anti-HIV microbicides was investigated by exploring the perceptibility variables associated with prototype formulations. Four focus groups with 29 women, aged 18–45, were conducted to consider gel prototypes with varied physicochemical and rheological properties. Participants responded favorably to the concept of long-acting vaginal gels as microbicides. Distinctions in understandings and stated needs regarding product dosing, characteristics, and effectiveness offer valuable insights into product design. Long-acting vaginal gels capable of protecting against HIV/STIs will be a viable option among potential users, with dosing frequency being an important factor in willingness to use.

Resumen

El entendimiento inicial y la aceptabilidad anticipada de geles vaginales de acción prolongada como potenciales anti-VIH microbicidas por parte de las mujeres, fueron investigados explorando variables de perceptibilidad asociadas a formulaciones prototípicas. Para examinar los prototipos de geles con diferentes propiedades fisicoquímicas y reológicas, se realizaron cuatro grupos focales con 29 mujeres entre las edades de 18–45 años. Las participantes respondieron favorablemente al concepto de geles vaginales de acción prolongada como microbicidas. Distinciones en el entendimiento y las necesidades expresadas en cuanto a dosificación, características, y eficacia del producto ofrecen conocimiento de valor para el diseño del mismo. Los geles vaginales de acción prolongada capaces de proteger contra el VIH/ITS serán una opción viable entre consumidoras potenciales, siendo la frecuencia de dosificación un factor importante en la disposición al uso.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
£29.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (United Kingdom)

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. World Health Organization (WHO). Global summary of the AIDS epidemic. Geneva: World Health Organization, 2011. http://www.who.int/hiv/data/2012_epi_core_en.png. Accessed Aug 13 2013.

  2. Grant RM, Lama JR, Anderson PL, et al. Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. N Engl J Med. 2010;363:2587–99.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  3. Baeten JM, Donnell D, Ndase P, et al. Antiretroviral prophylaxis for HIV prevention in heterosexual men and women. N Engl J Med. 2012;367:399–410.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  4. Thigpen MC, Kebaabetswe PM, Paxton LA, et al. Antiretroviral preexposure prophylaxis for heterosexual HIV transmission in Botswana. N Engl J Med. 2012;367:423–34.

    Article  CAS  PubMed  Google Scholar 

  5. WHO. Microbicides. 2013. http://www.who.int/hiv/topics/microbicides/microbicides/en/. Accessed Aug 13, 2013.

  6. Abdool Karim Q, Abdool Karim SS, Frohlich JA, et al. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science. 2010;329:1168–74.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  7. Rohan LC, Sassi AB. Vaginal drug delivery systems for HIV prevention. AAPS J. 2009;11:78.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  8. Romano J, Malcolm RK, Garg S, Rohan LC, Kaptur PE. Microbicide delivery: formulation technologies and strategies. Curr Opin HIV AIDS. 2008;3:558–66.

    Article  PubMed  Google Scholar 

  9. AVAC. Ongoing microbicide trials. 2013. http://data.avac.org/OngoingMicrobicideTrials.aspx. Accessed Aug 13 2013.

  10. Johnson TJ, Clark MR, Albright TH, et al. A 90-day tenofovir reservoir intravaginal ring for mucosal HIV prophylaxis. Antimicrob Agents Chemother. 2012;56:6272–83.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  11. Tasoglu S, Rohan LC, Katz DF, Szeri AJ. Transient swelling, spreading, and drug delivery by a dissolved anti-HIV microbicide-bearing film. Phys Fluids. 2013;25:31901.

    Article  Google Scholar 

  12. Carballo-Diéguez A, Dolezal C, Bauermeister JA, O’Brien W, Ventuneac A, Mayer K. Preference for gel over suppository as delivery vehicle for a rectal microbicide: results of a randomised, crossover acceptability trial among men who have sex with men. Sex Transm Infect. 2008;84(6):483–7.

    Article  PubMed Central  PubMed  Google Scholar 

  13. Mohammed Fayaz A, Ao Z, Girilal M, et al. Inactivation of microbial infectiousness by silver nanoparticles-coated condom: a new approach to inhibit HIV- and HSV-transmitted infection. Int J Nanomed. 2012;7:5007–18.

    CAS  Google Scholar 

  14. Ball C, Krogstad E, Chaowanachan T, Woodrow KA. Drug-eluting fibers for HIV-1 inhibition and contraception. PLoS ONE. 2012;7:e49792.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  15. Singer R, Mawson P, Derby N, et al. An intravaginal ring that releases the NNRTI MIV-150 reduces SHIV transmission in macaques. Sci Transl Med. 2012;4:150ra123.

    Article  PubMed  Google Scholar 

  16. Baum MM, Butkyavichene I, Gilman J, et al. An intravaginal ring for the simultaneous delivery of multiple drugs. J Pharm Sci. 2012;101:2833–43.

    Article  CAS  PubMed  Google Scholar 

  17. Kiser PF, Johnson TJ, Clark JT. State of the art in intravaginal ring technology for topical prophylaxis of HIV infection. AIDS Rev. 2012;14:62–77.

    PubMed  Google Scholar 

  18. Clark MR, Johnson TJ, McCabe RT, et al. A hot-melt extruded intravaginal ring for the sustained delivery of the antiretroviral microbicide UC781. J Pharm Sci. 2012;101:576–87.

    Article  CAS  PubMed  Google Scholar 

  19. Romano J, Variano B, Coplan P, et al. AIDS Res Hum Retroviruses. 2009;25:483–8.

    Article  CAS  PubMed  Google Scholar 

  20. Severy LJ, Newcomer S. Critical issues in contraceptive and STI acceptability research. J Soc Issues. 2005;61:45–65.

    Article  Google Scholar 

  21. Severy LJ, Tolley E, Woodsong C, Guest G. A framework for examining the sustained acceptability of microbicides. AIDS Behav. 2005;9(1):121–31.

    Article  PubMed  Google Scholar 

  22. Mantell JE, Myer L, Carballo-Diéguez A, et al. Microbicide acceptability research: current approaches and future directions. Soc Sci Med. 2005;60(2):319–30.

    Article  PubMed  Google Scholar 

  23. Darroch JE, Frost JJ. Women’s interest in vaginal microbicides. Fam Plan Perspect. 1999;31(1):16–23.

    Article  CAS  Google Scholar 

  24. Hammett TM, Mason TH, Joanis CL, et al. Acceptability of formulations and application methods for vaginal microbicides among drug-involved women: results of product trials in three cities. Sex Transm Dis. 2000;27(2):119–26.

    Article  CAS  PubMed  Google Scholar 

  25. Whitehead SJ, Kilmarx PH, Blanchard K, et al. Acceptability of Carraguard vaginal gel use among Thai couples. AIDS. 2006;20(17):2141–8.

    Article  PubMed  Google Scholar 

  26. Kamali A, Byomire H, Muwonge C, et al. A randomised placebo-controlled safety and acceptability trial of PRO 2000 vaginal microbicide gel in sexually active women in Uganda. Sex Transm Infect. 2010;86(3):222–6.

    Article  PubMed  Google Scholar 

  27. Morrow KM, Fava JL, Rosen RK, et al. Designing preclinical perceptibility measures to evaluate topical vaginal gel formulations: relating user perceptions and experiences to formulation properties. AIDS Res Hum Retroviruses. 2013. doi:10.1089/AID.2013.0099.

  28. Braun V, Clarke V. Using thematic analysis in psychology. Qual Res Psychol. 2006;3:77–101.

    Article  Google Scholar 

  29. Turner AN, Van Damme K, Jamieson DJ, et al. Predictors of adherent use of diaphragms and microbicide gel in a four-arm, randomized pilot study among female sex workers in Madagascar. Sex Transm Dis. 2009;36(4):249–57.

    Article  PubMed  Google Scholar 

  30. van der Straten A, Van Damme L, Haberer JE, Bangsberg DR. Unraveling the divergent results of pre-exposure prophylaxis trials for HIV prevention. AIDS. 2012;26(7):F13–9.

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

The authors are grateful to the women who participated in the study and the community-based organizations that collaborated to facilitate recruitment efforts. The project described was supported by National Institute of Allergy and Infectious Diseases (NIAID) Grant U19 AI077289 (Buchheit, PI), the National Institute of Child Health and Human Development (NICHD) Grant K24 HD062645 (Morrow, PI), and supported in part by NIAID Grant P30 AI042853 (Carpenter, PI) through the Lifespan/Tufts/Brown Center for AIDS Research. The content is solely the responsibility of the authors and does not necessarily represent the official views of NIAID, NICHD, or the National Institutes of Health.

Conflict of interest

The authors declare no conflicts of interest.

Author information

Author notes

  1. Patrick F. Kiser

    Present address: Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA

  2. Jacob J. van den Berg

    Present address: Department of Medicine, The Warren Alpert Medical School of Brown University, Providence, RI, USA

  3. Dana E. Bregman

    Present address: Hofstra North Shore-LIJ School of Medicine, Hofstra University, Hempstead, NY, USA

  4. Lara A. Thompson

    Present address: School of Naturopathic Medicine, Bastyr University, Kenmore, WA, USA

  5. Kathleen M. Jensen

    Present address: School of Social Work, University of Texas at Austin, Austin, TX, USA

Authors and Affiliations

  1. Centers for Behavioral and Preventive Medicine, The Miriam Hospital, Providence, RI, USA

    Jacob J. van den Berg, Rochelle K. Rosen, Dana E. Bregman, Lara A. Thompson, Kathleen M. Jensen & Kathleen M. Morrow

  2. Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University, Providence, RI, USA

    Jacob J. van den Berg & Kathleen M. Morrow

  3. Department of Behavioral and Social Sciences, School of Public Health, Brown University, Providence, RI, USA

    Rochelle K. Rosen

  4. Department of Bioengineering, University of Utah, Salt Lake City, UT, USA

    Patrick F. Kiser

  5. Department of Biomedical Engineering, Duke University, Durham, NC, USA

    David F. Katz

  6. Department of Obstetrics and Gynecology, Duke University, Durham, NC, USA

    David F. Katz

  7. ImQuest BioSciences, Inc., Frederick, MD, USA

    Karen Buckheit & Robert W. Buckheit Jr.

  8. Division of Infectious Diseases, The Miriam Hospital, 164 Summit Avenue, Providence, RI, 02906, USA

    Jacob J. van den Berg

Authors
  1. Jacob J. van den Berg
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rochelle K. Rosen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Dana E. Bregman
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Lara A. Thompson
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Kathleen M. Jensen
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Patrick F. Kiser
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. David F. Katz
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Karen Buckheit
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Robert W. Buckheit Jr.
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Kathleen M. Morrow
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jacob J. van den Berg.

Rights and permissions

Reprints and permissions

About this article

Cite this article

van den Berg, J.J., Rosen, R.K., Bregman, D.E. et al. “Set it and Forget it”: Women’s Perceptions and Opinions of Long-Acting Topical Vaginal Gels. AIDS Behav 18, 862–870 (2014). https://doi.org/10.1007/s10461-013-0652-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10461-013-0652-4

Keywords

Palabras claves

Search

Navigation