[go: up one dir, main page]
More Web Proxy on the site http://driver.im/
Skip to main content
Springer Nature Link
Log in

Epidermal growth factor receptor (EGFR) as a therapeutic target in rheumatoid arthritis

  • Review Article
  • Published:
Clinical Rheumatology Aims and scope Submit manuscript

    We’re sorry, something doesn't seem to be working properly.

    Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

Abstract

The epidermal growth factor receptor (EGFR) has an important role in the hyperplastic growth of tumor. Similar to tumor growth, rheumatoid arthritis (RA) synovium is hyperplastic, invasive, and expresses EGFR and its ligands. Activation of EGFR signaling is responsible for synovial fibroblast proliferation in RA. Furthermore, in addition to its role in proliferation, EGFR and its ligands can induce cytokine production of synovial fibroblasts during the pathogenesis of RA. Agents that target EGFR have yielded promising results in animal experiments involving RA, pharmacologic modulations targeting EGFR, or its ligands may give rise to new therapeutic approaches for RA. In this review article, we will discuss the biological features of EGFR and summarize recent advances regarding the role of EGFR in the pathogenesis and treatment of RA.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
£29.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (United Kingdom)

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Yuan FL, Li X, Lu WG, Li CW, Xu RS, Dong J (2011) IL-33: a promising therapeutic target for rheumatoid arthritis? Expert Opin Ther Targets 15:529–534

    PubMed  CAS  Google Scholar 

  2. Li X, Yuan FL, Lu WG, Zhao YQ, Li CW, Li JP et al (2010) The role of interleukin-17 in mediating joint destruction in rheumatoid arthritis. Biochem Biophys Res Commun 397:131–135

    Article  PubMed  CAS  Google Scholar 

  3. Pickens SR, Chamberlain ND, Volin MV, Gonzalez M, Pope RM, Mandelin AM 2nd et al (2011) Anti-CXCL5 therapy ameliorates IL-17-induced arthritis by decreasing joint vascularization. Angiogenesis 14:443–455

    Article  PubMed  CAS  Google Scholar 

  4. Marrelli A, Cipriani P, Liakouli V, Carubbi F, Perricone C, Perricone R et al (2011) Angiogenesis in rheumatoid arthritis: a disease specific process or a common response to chronic inflammation? Autoimmun Rev 10:595–598

    Article  PubMed  CAS  Google Scholar 

  5. Semerano L, Clavel G, Assier E, Denys A, Boissier MC (2011) Blood vessels, a potential therapeutic target in rheumatoid arthritis? Jt Bone Spine 78:118–123

    Article  Google Scholar 

  6. Szekanecz Z, Besenyei T, Paragh G, Koch AE (2009) Angiogenesis in rheumatoid arthritis. Autoimmunity 42:563–573

    Article  PubMed  CAS  Google Scholar 

  7. Bo GP, Zhou LN, He WF, Luo GX, Jia XF, Gan CJ et al (2009) Analyses of differential proteome of human synovial fibroblasts obtained from arthritis. Clin Rheumatol 28:191–199

    Article  PubMed  Google Scholar 

  8. Larsen AK, Ouaret D, El Ouadrani K, Petitprez A (2011) Targeting EGFR and VEGF(R) pathway cross-talk in tumor survival and angiogenesis. Pharmacol Ther 131:80–90

    Article  PubMed  CAS  Google Scholar 

  9. Swanson CD, Akama-Garren EH, Stein EA, Petralia JD, Ruiz PJ, Edalati A et al (2012) Inhibition of epidermal growth factor receptor tyrosine kinase ameliorates collagen-induced arthritis. J Immunol 188:3513–3521

    Article  PubMed  CAS  Google Scholar 

  10. Shiozawa S, Shiozawa K, Tanaka Y, Morimoto I, Uchihashi M, Fujita T et al (1989) Human epidermal growth factor for the stratification of synovial lining layer and neovascularisation in rheumatoid arthritis. Ann Rheum Dis 48:820–828

    Article  PubMed  CAS  Google Scholar 

  11. Sumariwalla PF, Jin P, Zhang J, Ni I, Crawford D, Shepard HM et al (2008) Antagonism of the human epidermal growth factor receptor family controls disease severity in murine collagen-induced arthritis. Arthritis Rheum 58:3071–3080

    Article  PubMed  CAS  Google Scholar 

  12. Gompels LL, Malik NM, Madden L, Jin P, Feldmann M, Shepard HM et al (2011) Human epidermal growth factor receptor bispecific ligand trap RB200: abrogation of collagen-induced arthritis in combination with tumour necrosis factor blockade. Arthritis Res Ther 13:R161

    Article  PubMed  CAS  Google Scholar 

  13. Yamane S, Ishida S, Hanamoto Y, Kumagai K, Masuda R, Tanaka K et al (2008) Proinflammatory role of amphiregulin, an epidermal growth factor family member whose expression is augmented in rheumatoid arthritis patients. J Inflamm (Lond) 5:5

    Article  Google Scholar 

  14. Kop EN, Kwakkenbos MJ, Teske GJ, Kraan MC, Smeets TJ, Stacey M et al (2005) Identification of the epidermal growth factor-TM7 receptor EMR2 and its ligand dermatan sulfate in rheumatoid synovial tissue. Arthritis Rheum 52:442–450

    Article  PubMed  CAS  Google Scholar 

  15. Sullivan T, Benjamin CG, Kempf PW, Deeken JF (2010) Cetuximab in the treatment of rheumatoid arthritis. J Clin Rheumatol 16:32–33

    Article  PubMed  Google Scholar 

  16. Voldborg BR, Damstrup L, Spang-Thomsen M, Poulsen HS (1997) Epidermal growth factor receptor (EGFR) and EGFR mutations, function and possible role in clinical trials. Ann Oncol 8:1197–1206

    Article  PubMed  CAS  Google Scholar 

  17. Burgess AW, Cho HS, Eigenbrot C, Ferguson KM, Garrett TP, Leahy DJ et al (2003) An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors. Mol Cell 12:541–552

    Article  PubMed  CAS  Google Scholar 

  18. Ogiso H, Ishitani R, Nureki O, Fukai S, Yamanaka M, Kim JH et al (2002) Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains. Cell 110:775–787

    Article  PubMed  CAS  Google Scholar 

  19. Lemmon MA (2009) Ligand-induced ErbB receptor dimerization. Exp Cell Res 315:638–648

    Article  PubMed  CAS  Google Scholar 

  20. Schlessinger J (2002) Ligand-induced, receptor-mediated dimerization and activation of EGF receptor. Cell 110:669–672

    Article  PubMed  CAS  Google Scholar 

  21. Yarden Y, Sliwkowski MX (2001) Untangling the ErbB signalling network. Nat Rev Mol Cell Biol 2:127–137

    Article  PubMed  CAS  Google Scholar 

  22. Citri A, Yarden Y (2006) EGF-ERBB signalling: towards the systems level. Nat Rev Mol Cell Biol 7:505–516

    Article  PubMed  CAS  Google Scholar 

  23. Marquardt H, Hunkapiller MW, Hood LE, Twardzik DR, De Larco JE, Stephenson JR et al (1983) Transforming growth factors produced by retrovirus-transformed rodent fibroblasts and human melanoma cells: amino acid sequence homology with epidermal growth factor. Proc Natl Acad Sci U S A 80:4684–4688

    Article  PubMed  CAS  Google Scholar 

  24. Shoyab M, McDonald VL, Bradley JG, Todaro GJ (1988) Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7. Proc Natl Acad Sci U S A 85:6528–6532

    Article  PubMed  CAS  Google Scholar 

  25. Margolis B, Li N, Koch A, Mohammadi M, Hurwitz DR, Zilberstein A et al (1990) The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma. EMBO J 9:4375–4380

    PubMed  CAS  Google Scholar 

  26. Shing Y, Christofori G, Hanahan D, Ono Y, Sasada R, Igarashi K et al (1993) Betacellulin: a mitogen from pancreatic beta cell tumors. Science 259:1604–1607

    Article  PubMed  CAS  Google Scholar 

  27. Seshacharyulu P, Ponnusamy MP, Haridas D, Jain M, Ganti AK, Batra SK (2012) Targeting the EGFR signaling pathway in cancer therapy. Expert Opin Ther Targets 16:15–31

    Article  PubMed  CAS  Google Scholar 

  28. Killock D (2012) Experimental arthritis: targeting EGFR to fight synovitis. Nat Rev Rheumatol 8:247

    Article  PubMed  Google Scholar 

  29. Young CL, Adamson TC 3rd, Vaughan JH, Fox RI (1984) Immunohistologic characterization of synovial membrane lymphocytes in rheumatoid arthritis. Arthritis Rheum 27:32–39

    Article  PubMed  CAS  Google Scholar 

  30. Lo SF, Wan L, Lin HC, Huang CM, Chen SY, Liu SC et al (2011) Association of rheumatoid arthritis risk with EGFR genetic polymorphisms in Taiwan’s Han Chinese population. Rheumatol Int 32(8):2301–2306

    Article  PubMed  Google Scholar 

  31. Yarden Y (2001) The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities. Eur J Cancer 37(Suppl 4):S3–S8

    Article  PubMed  CAS  Google Scholar 

  32. Hallbeck AL, Walz TM, Briheim K, Wasteson A (2005) TGF-alpha and ErbB2 production in synovial joint tissue: increased expression in arthritic joints. Scand J Rheumatol 34:204–211

    Article  PubMed  CAS  Google Scholar 

  33. Shepard HM, Brdlik CM, Schreiber H (2008) Signal integration: a framework for understanding the efficacy of therapeutics targeting the human EGFR family. J Clin Invest 118:3574–3581

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

This work was supported by the China National Science Foundation grants No.30901526 and No. 81101372.

Disclosures

None.

Author information

Authors and Affiliations

  1. The Third Hospital Affiliated to Nantong University, Wuxi, Jiangsu, 214041, China

    Feng-Lai Yuan, Xia Li, Wei-Guo Lu, Jun-Ming Sun, Dong-Lin Jiang & Rui-Sheng Xu

Authors
  1. Feng-Lai Yuan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xia Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Wei-Guo Lu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jun-Ming Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Dong-Lin Jiang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Rui-Sheng Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Feng-Lai Yuan.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yuan, FL., Li, X., Lu, WG. et al. Epidermal growth factor receptor (EGFR) as a therapeutic target in rheumatoid arthritis. Clin Rheumatol 32, 289–292 (2013). https://doi.org/10.1007/s10067-012-2119-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10067-012-2119-9

Keywords

Search

Navigation