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The clinicopathologic spectrum of mature aggressive B cell lymphomas

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Abstract

Our understanding of mature aggressive B cell lymphomas has evolved significantly in the last years as reflected in the 2016 update of the WHO lymphoma classification. A main topic of the 2016 European Association for Haematopathology/Society of Hematopathology lymphoma workshop in Basel therefore was the clinicopathological spectrum of mature aggressive B cell lymphomas with the exception of conventional diffuse large B cell lymphoma. In this review, we summarize two sessions dedicated to “high-grade B cell lymphomas, with MYC and BCL2 and/or BCL6 rearrangements (so-called double/triple-hit lymphomas)” and “high-grade B cell lymphomas, NOS” as defined in the 2016 update of the WHO lymphoma classification, Burkitt lymphoma and related neoplasms, and terminally differentiated aggressive B cell lymphomas. One focus was on cases of Burkitt lymphoma with unusual clinical features such as spontaneous regression or association with immunosuppression, and the new provisional category of Burkitt-like lymphoma with 11q aberration. The large numbers of cases submitted for the new high-grade categories with or without genetic “double/triple hit” demonstrated the broad clinical and pathological spectrum of this group and gave ample opportunity for discussion. In this review, current definitions and our understanding of the main high-grade categories, potential problem areas, and suggestions for the immunophenotypic and genetic work-up of these neoplasms are discussed and illustrated by many interesting and challenging cases submitted to the workshop.

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Authors and Affiliations

  1. Department of Laboratory Medicine and Pathology, The Mayo Clinic, 13400 E. Shea Boulevard, Collaborative Research Building, 1-265, Scottsdale, AZ, 85259, USA

    Lisa Rimsza

  2. Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA

    Stefania Pittaluga

  3. Institute of Pathology and Genetics, University Hospital Basel, University of Basel, Basel, Switzerland

    Stephan Dirnhofer

  4. Department of Pathology, Hospital Henri Mondor, INSERM U955, Universite Paris Est, Creteil, France

    Christiane Copie-Bergman

  5. Institute of Pathology, University Hospital Lausanne, Lausanne, Switzerland

    Laurence de Leval

  6. Section of Pathology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy

    Fabio Facchetti

  7. Unit of Hematopathology, European Institute of Oncology, Milan, Italy

    Stefano Pileri

  8. Institute of Pathology, University of Würzburg and Comprehensive Cancer Center Mainfranken, Würzburg, Germany

    Andreas Rosenwald

  9. Department of Histopathology, Royal Marsden Hospital, Sutton, UK

    Andrew Wotherspoon

  10. Institute of Pathology and Neuropathology and Comprehensive Cancer Center, University Hospital Tübingen, Liebermeisterstrasse 8, 72076, Tübingen, Germany

    Falko Fend

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  1. Lisa Rimsza
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  2. Stefania Pittaluga
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This article is part of the Topical Collection on Aggressive B-cell lymphomas and histiocytic neoplasias

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Rimsza, L., Pittaluga, S., Dirnhofer, S. et al. The clinicopathologic spectrum of mature aggressive B cell lymphomas. Virchows Arch 471, 453–466 (2017). https://doi.org/10.1007/s00428-017-2199-7

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