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The neurovascular unit and the pathophysiologic basis of diabetic retinopathy

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Abstract

Purpose

To relate the concept of the retinal neurovascular unit and its alterations in diabetes to the pathophysiology of diabetic retinopathy.

Methods

Case illustrations and conceptual frameworks are presented that illustrate adaptive and maladaptive “dis-integration” of the retinal neurovascular unit with the progression of diabetes.

Results

Retinopathy treatment should address pathophysiologic processes rather than pathologic lesions as is current practice.

Conclusions

Future improvements in the treatment of diabetic retinopathy requires deeper understanding of the cellular and molecular changes induced by diabetes, coupled with the use of quantitative phenotyping methods that assess the pathophysiologic processes.

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Acknowledgments

This work was supported by R01EY20582, DP3DK094292, P30EY007003, The Taubman Institute, and Research to Prevent Blindness, and previously by the Jack and Nancy Turner Professorship at Penn State University.

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Authors and Affiliations

  1. Department of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, University of Michigan Medical School, 1000 Wall St, Ann Arbor, MI, 48105, USA

    Thomas W. Gardner & Jose R. Davila

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  1. Thomas W. Gardner
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  2. Jose R. Davila
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Corresponding author

Correspondence to Thomas W. Gardner.

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Gardner, T.W., Davila, J.R. The neurovascular unit and the pathophysiologic basis of diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol 255, 1–6 (2017). https://doi.org/10.1007/s00417-016-3548-y

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  • DOI: https://doi.org/10.1007/s00417-016-3548-y

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