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Electrophysiological and behavioral effects of frontal transcranial direct current stimulation on cognitive fatigue in multiple sclerosis

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Abstract

Fatigue is one of the most common and debilitating symptoms affecting patients with multiple sclerosis (MS). Sustained cognitive effort induces cognitive fatigue, operationalized as subjective exhaustion and fatigue-related objective alertness decrements with time-on-task. During prolonged cognitive testing, MS patients show increased simple reaction times (RT) accompanied by lower amplitudes and prolonged latencies of the P300 event-related potential. Previous studies suggested a major role of structural and functional abnormalities in the frontal cortex including a frontal hypo-activation in fatigue pathogenesis. In the present study we investigated the neuromodulatory effect of transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex (DLPFC) on objective measures of fatigue-related decrements in cognitive performance in MS patients. P300 during an auditory oddball task and simple reaction times in an alertness test were recorded at baseline, during and after stimulation. Compared to sham, anodal tDCS caused an increase in P300 amplitude that persisted after the end of stimulation and eliminated the fatigue-related increase in RT over the course of a testing session. Our findings demonstrate that anodal tDCS over the left DLPFC can counteract performance decrements associated with fatigue thereby leading to an improvement in the patient’s ability to cope with sustained cognitive demands. This provides causal evidence for the functional relevance of the left DLPFC in fatigue pathophysiology. The results indicate that tDCS-induced modulations of frontal activity can be an effective therapeutic option for the treatment of fatigue-related declines in cognitive performance in MS patients.

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Acknowledgements

We are grateful to all patients for their involvement. We wish to thank Julian Moritz Kauk for his help in behavioral data analysis.

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Authors and Affiliations

  1. Department of Neurology, Otto-von-Guericke University Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany

    Marina Fiene, Katharina S. Rufener, Maria Kuehne, Mike Matzke, Hans-Jochen Heinze & Tino Zaehle

  2. Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany

    Marina Fiene

  3. Center for Behavioral Brain Sciences, Magdeburg, Germany

    Katharina S. Rufener, Hans-Jochen Heinze & Tino Zaehle

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  1. Marina Fiene
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  2. Katharina S. Rufener
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Correspondence to Tino Zaehle.

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The study was approved by the local ethics committee of the University Hospital Magdeburg.

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Informed consent was obtained from all patients prior to their inclusion in this study.

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Fiene, M., Rufener, K.S., Kuehne, M. et al. Electrophysiological and behavioral effects of frontal transcranial direct current stimulation on cognitive fatigue in multiple sclerosis. J Neurol 265, 607–617 (2018). https://doi.org/10.1007/s00415-018-8754-6

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  • DOI: https://doi.org/10.1007/s00415-018-8754-6

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