[go: up one dir, main page]
More Web Proxy on the site http://driver.im/
Skip to main content

Advertisement

Springer Nature Link
Log in

Current status of clinical breath analysis

  • Published:
Applied Physics B Aims and scope Submit manuscript

Abstract

Clinical breath analysis remains in its infancy, despite the fact that its potential has been recognized for centuries and that blood, urine, and other bodily fluids and tissues are routinely analyzed to diagnose disease or to monitor therapy. This review discusses the present status of clinical breath analysis and suggests reasons why breath analysis has not received similar widespread clinical use. Currently, a number of marker molecules have been identified in breath that could be used to identify disease, disease progression, or to monitor therapeutic intervention and this list is expected increase dramatically since the analysis of breath is ideally suited for population-based studies in the developed and underdeveloped world. Recent advances in analytical instrumentation have suggested that the use of exhaled breath in medicine should now be re-examined. In particular, the availability of real-time, portable monitors will represent a breakthrough for clinical diagnosis. Progress in clinical breath analysis will require collaboration amongst device makers, experts in breath analysis, and clinicians.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
£29.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (United Kingdom)

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. L. Pauling, A.B. Robinson, R. Teranishi, P. Cary, Proc. Nat. Acad. Sci. 68, 2374 (1971)

    Article  ADS  Google Scholar 

  2. B.O. Jansson, B.T. Larsson, J. Lab. Clin. Med. 74, 961 (1969)

    Google Scholar 

  3. S. Chen, L. Zieve, V. Mahadevan, J. Lab. Clin. Med. 75, 628 (1970)

    Google Scholar 

  4. C.A. Riely, G. Cohen, M. Lieberman, Science 183, 208 (1974)

    Article  ADS  Google Scholar 

  5. J.R. Dannecker Jr., E.G. Shaskan, M. Phillips, Anal. Biochem. 114, 1 (1981)

    Article  Google Scholar 

  6. K.B. Schwarz, J.M. Cox, S. Sharma, L. Clement, J. Humphrey, C. Gleason, H. Abbey, S.S. Sehnert, T.H. Risby, J. Pediatr. Gastr. Nutr. 25, 408 (1997)

    Article  Google Scholar 

  7. T.H. Risby, W. Maley, R.P. Scott, G.B. Bulkley, M. Kazui, S.S. Sehnert, K.B. Schwarz, J. Potter, E. Mezey, A.S. Klein, P. Colombani, J. Fair, W.T. Merritt, C. Beattie, M.C. Mitchell, G.M. Williams, B.A. Perler, R.T. Donham, J.F. Burdick, Surgery 115, 94 (1994)

    Google Scholar 

  8. K.A. Cope, Breath Biomarkers of Exposure and Disease. PhD Dissertation, Johns Hopkins University (2002)

  9. M. Refat, T.J. Moore, M. Kazui, T.H. Risby, J.A. Perman, K.B. Schwarz, Pediatr. Res. 30, 396 (1991)

    Article  Google Scholar 

  10. A.S. Modak, 13C Breath tests: transition from research to clinical practice. In: Breath Analysis for Clinical Diagnosis and Therapeutic Monitoring, ed. by A. Amann, D. Smith (World Scientific, Singapore, 2005) pp. 457–478

  11. S. Kharitonov, K. Alving, P.J. Barnes, Eur. Resp. J. 10, 1683 (1997)

    Article  Google Scholar 

  12. Recommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Lower Respiratory Nitric Oxide and Nasal Nitric Oxide in Adults and Children-1999. This Official Statement of the American Thoracic Society was Adopted by the ATS Board of Directors, July 1999. Am. J. Respir. Crit. Care Med. 160, 2104 (1999)

  13. T.H. Risby, S.S. Sehnert, Free Radical Biol. Med. 27, 1182 (1999)

    Article  Google Scholar 

  14. J.K. Schubert, W. Miekisch, T. Bireken, K. Geiger, G.F.E. Noldge-Schomberg, Biomarkers 10, 138 (2005)

    Article  Google Scholar 

  15. J.D. Pleil, D. Kim, J.D. Prah, D.L. Ashley, S.M. Rappaport, The unique value of breath biomarkers for estimating pharmacokinetic rate conatnats and body burden from environmental exposure. In: Breath Analysis for Clinical Diagnosis and Therapeutic Monitoring, ed. by A. Amann, D. Smith (World Scientific, Singapore, 2005) pp. 347–359

  16. J.K. Furne, J.R. Springfield, S.B. Ho, M.D. Levitt, J. Lab. Clin. Med. 142, 52 (2003)

    Article  Google Scholar 

  17. K.A. Cope, M.T. Watson, W.M. Foster, S.S. Sehnert, T.H. Risby, J. Appl. Physiol. 96, 1371 (2004)

    Article  Google Scholar 

  18. J.H. Gross, Mass Spectrometry A Textbook (Springer, New York, 2004)

    Google Scholar 

  19. F.M. Benoit, W.R. Davidson, A.M. Lovett, S. Nacson, A. Ngo, Int. Arch. Occup. Environ. Health 55, 113 (1985)

    Article  Google Scholar 

  20. D. Smith, P. Spanel, Selected ion flow tube mass spectrometry, SIFT-MS, for on-line trace gas analysis of breath. In: Breath Analysis for Clinical Diagnosis and Therapeutic Monitoring, ed by A. Amann, D. Smith (World Scientific, Singapore, 2005) pp. 3–34

  21. M. Phillips, J. Herrera, S. Krishnan, M. Zain, J. Greenberg, R.N. Cataneo, J. Chromatogr. B 729, 75 (1999)

    Article  Google Scholar 

  22. G. Wysocki, M. McCurdy, S. So, D. Weidmann, C. Roller, F.K. Tittel, Appl. Opt. 43, 6040 (2004)

    Article  ADS  Google Scholar 

  23. L.R. Narasimhan, W. Goodman, C.K. Patel, Proc. Nat. Acad. Sci. USA 98, 46121 (2001)

    Article  Google Scholar 

  24. S.A. Kharitonov, P.J. Barnes, Biomarkers 7, 1 (2002)

    Article  Google Scholar 

  25. S.M. Studer, I. Rosas, K.A. Cope, J. Krishnan, J.B. Orens, T.H. Risby, J. Heart Lung Transplant. 20, 1158 (2001)

    Article  Google Scholar 

  26. J.B. McCafferty, T.A. Bradshaw, S. Tate, A.P. Greening, J.A. Innes, Thorax 59, 694 (2004)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Environmental Health Sciences, Bloomberg School of Public Health, the Johns Hopkins Medical Institutions, Baltimore, MD, 21205, USA

    T.H. Risby

  2. Department of Medicine, Division of Gastroenterology, School of Medicine, the Johns Hopkins Medical Institutions, Baltimore, MD, 21205, USA

    S.F. Solga

Authors
  1. T.H. Risby
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S.F. Solga
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to T.H. Risby.

Additional information

PACS

01.30.Rr; 07.57.Ty; 07.60.Rd; 07.75.+h; 33.80.-b; 82.80.Bg; 82.80.Dy; 82.80.Rt; 87.14.-g; 87.62.+n

Rights and permissions

Reprints and permissions

About this article

Cite this article

Risby, T., Solga, S. Current status of clinical breath analysis. Appl. Phys. B 85, 421–426 (2006). https://doi.org/10.1007/s00340-006-2280-4

Download citation

  • Received:

  • Revised:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00340-006-2280-4

Keywords

Search

Navigation