Abstract
Inbred mouse strains derived from the species Mus spretus have been very informative in the study of certain gene polymorphisms in inflammation and infection. Based on our interest in sepsis, we used SPRET/EiJ mice and mapped several critical loci that are linked to sensitivity to cytokine-induced inflammation and endotoxemia. These studies were based on prominent phenotypes that have never been observed in strains derived from Mus musculus and we mapped them at a resolution that enables us to draw conclusions on the mechanisms. Now that the genome of SPRET/EiJ has been sequenced, and other tools have become available, it is time to revisit this strain and emphasize its advantages and disadvantages as a research tool and a discovery platform.
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Acknowledgements
Research in the laboratory was funded by the Agency for Innovation of Science and Technology in Flanders (IWT), the Research Council of Ghent University (GOA program), the Research Foundation Flanders (FWO Vlaanderen), COST action BM1402, and the Interuniversity Attraction Poles Program of the Belgian Science Policy (IAP-VI-18).
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Timmermans, S., Souffriau, J., Vandewalle, J. et al. Using the inbred mouse strain SPRET/EiJ to provide novel insights in inflammation and infection research. Mamm Genome 29, 585–592 (2018). https://doi.org/10.1007/s00335-018-9751-x
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DOI: https://doi.org/10.1007/s00335-018-9751-x