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Microchip PCR

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Abstract

Miniaturization of genetic tests has become an important goal. This review surveys the current progress towards the miniaturization of tests based on the polymerase chain reaction (PCR). It examines the different types of PCR microchip designs, fabrication methods,and the components of a microchip PCR device. It also discusses the problems attributable to surface chemistry of microchip components (inhibition of PCR), and the static and dynamic surface passivation strategies developed for the solution of these difficulties

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA

    L. J. Kricka & P. Wilding

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  1. L. J. Kricka
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  2. P. Wilding
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Correspondence to L. J. Kricka.

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Kricka, L.J., Wilding, P. Microchip PCR. Anal Bioanal Chem 377, 820–825 (2003). https://doi.org/10.1007/s00216-003-2144-2

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  • DOI: https://doi.org/10.1007/s00216-003-2144-2

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