Abstract
A theoretical model of a cardiac muscle fiber (strand) based on core conductor principles and which includes a periodic intercalated disc structure has been developed. The model allows for examination of the mechanism of electrical propagation in cardiac muscle on a microscopic cell-to-cell level. The results of the model simulations demonstrate the discontinuous nature of electrical propagation in cardiac muscle and the inability of classical continuous cable theory to adequately describe propagation phenomena in cardiac muscle.
Similar content being viewed by others
References
Barr, L., M.M. Dewey, and W. Berger. Propagation of action potentials and the structure of the nexus in cardiac muscle.J. Gen. Physiol. 48:797–823, 1965.
Beeler, G.W. and H. Reuter. Reconstruction of the action potential of ventricular myocardial fibres.J. Physiol. London 286:177–210, 1977.
Chapman, R.A. and C.H. Fry. An analysis of the cable properties of frog ventricular myocardium.J. Physiol. London 283:263–281, 1978.
Clerc, L. Directional differences of impulse spread in trabecular muscle from mammalian heart.J. Physiol. London 255:335–346, 1976.
Crank, J. and P. Nicolson. A practical method for numerical evaluation of solutions of partial differential equations of the heat conduction type.Proc. Cambridge Philos. Soc. 43:50–77, 1947.
Draper, M.H. and M. Mya-Tu. A comparison of the conduction velocity of cardiac tissue of various animals.Q. J. Exp. Physiol. 44:91–109, 1959.
Freygang, W.H. and W. Trautwein. The structural implications of the linear electrical properties of cardiac Purkinje strands.J. Gen. Physiol. 55:524–547, 1970.
Heppner, D.B. and R. Plonsey. Simulation of electrical interaction of cardiac cells.Biophys. J. 10 1057–1075, 1970.
Hodgkin, A.L. and A.F. Huxley. A quantitative description of membrane current and its application to conduction and excitation in nerve.J. Physiol. London 117:500–544, 1952.
Hodgkin, A.L. and W.A.H. Rushton. The electrical constants of a crustacean nerve fiber.Proc. R. Soc. London, Ser. B 133:444–508, 1946.
Lieberman, M., T. Sawanobori, J.M. Kootsey, and E.A. Johnson. A synthetic strand of cardiac muscle: Its passive electrical properties.J. Gen. Physiol. 65:527–550, 1975.
Lowenstein, W.R. Junctional intercellular communication: The cell-to-cell membrane channel.Physiol. Rev. 61:829–913, 1981.
McAllister, R.E., D. Noble, and R.W. Tsien. Reconstruction of the electrical activity of cardiac Purkinje fibers.J. Physiol. London 251:1–59, 1975.
McNutt, N.S. and R.S. Weinstein. Membrane ultrastructure at mammalian intercellular junctions.Prog. Biophys. Mol. Biol. 26:45–101, 1973.
Page, E. and L.P. McAllister. Studies on the intercalated discs of rat ventricular myocardial cells.J. Ultra. Res. 43:388–411, 1973.
Page, E. and Y. Shibata. Permeable junctions between cardiac cells.Ann. Rev. Physiol. 43:431–442, 1981.
Pollack, G.H. Intercellular coupling in the atrioventricular node and other tissues of the rabbit heart.J. Physiol. London 255:275–298, 1976.
Revel, J.P. and M.J. Karnovsky. Hexagonal arrays of subunits in intercellular junctions of the mouse heart and liver.J. Cell Biol. 12:571–588, 1962.
Sjostrand, F.S. and E. Anderson-Cedergren. Intercalated discs of heart muscle. InThe Structure and Function of Muscle, Vol. 1, edited by G. Bourne. New York: Academic Press, 1960, pp. 421–445.
Spach, M.S., W.T. Miller III, D.B. Geselowitz, R.C. Barr, J.R. Sommer, and E.A. Johnson. The discontinous nature of propagation in cardiac muscle: Evidence for recurrent discontinuities of intracellular resistance that affect the membrane currents.Circ. Res. 48:39–56, 1981.
Spira, A.W. The nexus in the intercalated disc of the canine heart: Quantitative data for the estimation of its resistance.J. Ultra. Res. 34:409–425, 1971.
Weidmann, S.. The electrical constants of Purkinje fibers.J. Physiol. London 118:348–360, 1952.
Weidmann, S. The diffusion of radiopotassium across intercalated disks of mammalian cardiac muscle.J. Physiol. London 187:323–342, 1966.
Woodbury, J.W. and W.E. Crill. On the problem of impulse conduction in the atrium. InNervous Inhibition, edited by L. Florey. New York: Plenum Press, 1961, pp. 24–35.
Woodbury, J.W. and W.E. Crill. The potential in the gap between two abutting cardiac cells.Biophys. J. 10:1076–1085, 1970.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Diaz, P.J., Rudy, Y. & Plonsey, R. Intercalated discs as a cause for discontinuous propagation in cardiac muscle: A theoretical simulation. Ann Biomed Eng 11, 177–189 (1983). https://doi.org/10.1007/BF02363285
Issue Date:
DOI: https://doi.org/10.1007/BF02363285