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Essential trace elements in humans

Serum arsenic concentrations in hemodialysis patients in comparison to healthy controls

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Abstract

Serum arsenic concentrations of persons suffering from renal failure and undergoing hemodialysis treatment (n=85) and of healthy controls (n=25) were determined by hydride-generation AAS technique after microwave digestion. The results were evaluated by comparing the values of both groups, considering physiological factors and individual data, as well as comorbid conditions of the hemodialysis (HD) patients. Serum arsenic levels were diminished in the patient group compared with controls (mean values 8.5±1.8 ng/mL vs 10.6±1.3 ng/mL). Furthermore, additional diseases within the hemodialysis group, particularly injuries of the central nervous system (CNS), vascular diseases, and cancer, were correlated to occasionally markedly decreased serum arsenic concentrations. It was concluded that arsenic homeostasis is disturbed by HD treatment and certain additional diseases. Desirable arsenic concentrations in the body seem to be reasonable. This consideration results in the conclusion that arsenic could play an essential role in human health. Thus, reference arsenic concentrations in different human tissues and body fluids should be established in order to recognize not only arsenic intoxication, but also arsenic deficiency. Perhaps arsenic deficiency contributes to the increased death risk of HD patients, and therefore, arsenic supplementations for patients with extremely low serum arsenic concentrations should be taken into account.

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Authors and Affiliations

  1. Institute for Analytical Chemistry, Karl-Franzens-University Graz, Universitätsplatz 1, 8010, Graz, Austria

    Daniel R. Mayer & Walter Kosmus

  2. Department of Nephrology, Karl-Franzens-University Graz, Medical Center, Auenbruggerplatz 11, 8036, Graz, Austria

    Helmut Pogglitsch

  3. Merkur Sanatorium, Eckerstraße 98, 8020, Graz, Austria

    David mayer

  4. Institute for Medical Chemistry and Pregl Laboratory, Karl-Franzens-University Graz, Harrachgasse 21, 8010, Graz, Austria

    Wolfgang Beyer

Authors
  1. Daniel R. Mayer
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  2. Walter Kosmus
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  3. Helmut Pogglitsch
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  4. David mayer
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  5. Wolfgang Beyer
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Mayer, D.R., Kosmus, W., Pogglitsch, H. et al. Essential trace elements in humans. Biol Trace Elem Res 37, 27–38 (1993). https://doi.org/10.1007/BF02789399

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  • DOI: https://doi.org/10.1007/BF02789399

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