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Antibacterial activity of Δ9-tetrahydrocannabinol and cannabidiol

  • Physiology and Growth
  • Published:
Antonie van Leeuwenhoek Aims and scope Submit manuscript

Abstract

The minimum inhibiting concentrations (MIC) of Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) for staphylococci and streptococci in broth are in the range of 1–5 μg/ml. In the same range, both compounds are also bactericidal. In media containing 4% serum or 5% blood the antibacterial activity is strongly reduced (MIC 50μg/ml). Gram-negative bacteria are resistant to THC and CBD.

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Authors and Affiliations

  1. Laboratory for Chemotherapy, National Institute of Public Health, Bilthoven, The Netherlands

    B. van Klingeren

  2. Laboratory for Pharmacology, National Institute of Public Health, Bilthoven, The Netherlands

    M. ten Ham

Authors
  1. B. van Klingeren
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  2. M. ten Ham
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van Klingeren, B., ten Ham, M. Antibacterial activity of Δ9-tetrahydrocannabinol and cannabidiol. Antonie van Leeuwenhoek 42, 9–12 (1976). https://doi.org/10.1007/BF00399444

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  • DOI: https://doi.org/10.1007/BF00399444

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