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Modification of the pendant ring of podophyllotoxin

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  • Podophyllotoxin Derivatives
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Cancer Chemotherapy and Pharmacology Aims and scope Submit manuscript

Summary

An improved route to quinonoid analogues of podophyllotoxin has been devised. Derivatives have been characterised by HPLC, NMR, and mass spectrometry; these include compounds in which the original reactivity of the lignan is modified by remote substition, which also retain the physiologically active configuration in the presence of bases.

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References

  1. Papers submitted to the First International Symposium on the Podophyllotoxins in Cancer Therapy, Southampton, July 1981

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Author notes

  1. Chang Kee Lim

    Present address: Division of Clinical Chemistry, Clinical Research Centre, Watford Road, Harrow, Middlesex, Great Britain

Authors and Affiliations

  1. Chemistry Department, Westfield College (University of London), Hampstead, NW3 7ST, London, Great Britain

    David C. Ayres & Chang Kee Lim

Authors
  1. David C. Ayres
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  2. Chang Kee Lim
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Additional information

This paper forms part 17 in the series ‘Lignans and Related Phenols’

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Ayres, D.C., Lim, C.K. Modification of the pendant ring of podophyllotoxin. Cancer Chemother. Pharmacol. 7, 99–101 (1982). https://doi.org/10.1007/BF00254529

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  • DOI: https://doi.org/10.1007/BF00254529

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