Abstract
Imaging is increasingly used for the diagnosis of retinal normality and the monitoring of retinal abnormalities. Many retinal vessel properties, such as small artery aneurysms, narrowing of incisions, etc., are related to systemic diseases. The morphology of retinal blood vessels themselves is related to cardiovascular disease and coronary artery disease in adults. The fundus image can intuitively reflect the retinal vessel lesions, and the computer-based image processing method can be used for auxiliary medical diagnosis. In this paper, a retinal vessel segmentation model, named as MLFF, is proposed to effectively extract and fuse multiple low-level features. Firstly, there are 25 low-level feature maps of fundus retinal vessel images that are analyzed and extracted. Then, the feature maps are fused by an AdaBoost classifier. Finally, the MLFF is trained and evaluated on public fundus images for vessel extraction dataset (DRIVE). The qualitative and quantitative experimental results show that our model can effectively detect the retinal vessels and outperforms other models including deep learning-based models.
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References
Abràmoff, M.D., Garvin, M.K., Sonka, M.: Retinal imaging and image analysis. IEEE Rev. Biomed. Eng. 3(3), 169–208 (2010)
Fraz, M., et al.: Blood vessel segmentation methodologies in retinal images - a survey. Comput. Methods Programs Biomed. 108(1), 407–433 (2012)
Waheed, Z., Usman Akram, M., Waheed, A., Khan, M.A., Shaukat, A., Ishaq, M.: Person identification using vascular and non-vascular retinal features. Comput. Electr. Eng. 53, 359–371 (2016)
Zhao, Y., et al.: Retinal artery and vein classification via dominant sets clustering-based vascular topology estimation. In: Frangi, A.F., Schnabel, J.A., Davatzikos, C., Alberola-López, C., Fichtinger, G. (eds.) MICCAI 2018. LNCS, vol. 11071, pp. 56–64. Springer, Cham (2018). https://doi.org/10.1007/978-3-030-00934-2_7
Zheng, H., Chang, L., Wei, T., Qiu, X., Lin, P., Wang, Y.: Registering retinal vessel images from local to global via multiscale and multicycle features. In: IEEE Computer Vision and Pattern Recognition Workshops, pp. 50–57, June 2016
Staal, J., Abramoff, M., Niemeijer, M., Viergever, M., van Ginneken, B.: Ridge-based vessel segmentation in color images of the retina. IEEE Trans. Med. Imaging 23(4), 501–509 (2004)
Srinidhi, C.L., Aparna, P., Rajan, J.: Recent advancements in retinal vessel segmentation. J. Med. Syst. 41(4), 1–22 (2017)
Li, T., Bo, W., Hu, C., Kang, H., Liu, H., Wang, K., Fu, H.: Applications of deep learning in fundus images: a review. Med. Image Anal. 69, 101971 (2021)
Alyoubi, W.L., Shalash, W.M., Abulkhair, M.F.: Diabetic retinopathy detection through deep learning techniques: a review. Inform. Med. Unlocked 20, 100377 (2020)
Lupascu, C.A., Tegolo, D., Trucco, E.: FABC: retinal vessel segmentation using adaboost. IEEE Trans. Inf. Technol. Biomed. 14(5), 1267–1274 (2010)
Yang, D., Liu, G., Ren, M., Xu, B., Wang, J.: A multi-scale feature fusion method based on u-net for retinal vessel segmentation. Entropy 22(8), 811 (2020). https://doi.org/10.3390/e22080811
Wu, Y., Xia, Y., Song, Y., Zhang, Y., Cai, W.: NFN\(+\): a novel network followed network for retinal vessel segmentation. Neural Netw. 126, 153–162 (2020)
Hoover, A., Kouznetsova, V., Goldbaum, M.: Locating blood vessels in retinal images by piecewise threshold probing of a matched filter response. IEEE Trans. Med. Imaging 19(3), 203–210 (2000)
Fraz, M.M., et al.: An ensemble classification-based approach applied to retinal blood vessel segmentation. IEEE. Trans. Biomed. Eng. 59(9), 2538–2548 (2012)
Owen, C.G., et al.: Measuring retinal vessel tortuosity in 10-year-old children: validation of the computer-assisted image analysis of the retina (CAIAR) program. Inve. Ophtha. Vis. Sci. 50(5), 2004–2010 (2009)
Shi, Z., Wang, T., Xie, F., Huang, Z., Zheng, X., Zhang, W.: MSU-net: a multi-scale u-net for retinal vessel segmentation. In: International Symposium on Artificial Intelligence in Medical Sciences, pp. 177–181 (2020)
Zhang, Y., Chen, Y., Zhang, K.: PCANet: pyramid context-aware network for retinal vessel segmentation. In: International Conference on Pattern Recognition, pp. 2073–2080 (2021)
Boudegga, H., Elloumi, Y., Akil, M., Bedoui, M.H., Kachouri, R., Abdallah, A.B.: Fast and efficient retinal blood vessel segmentation method based on deep learning network. Comput. Med. Imaging Graph. 90, 101902–101902 (2021)
Zhao, H., Li, H., Cheng, L.: Improving retinal vessel segmentation with joint local loss by matting. Pattern Recognit. 98, 107068 (2020)
Ding, L., Bawany, M.H., Kuriyan, A.E., Ramchandran, R.S., Wykoff, C.C., Sharma, G.: A novel deep learning pipeline for retinal vessel detection in fluorescein angiography. IEEE Trans. Image Process. 29, 6561–6573 (2020)
Ramos-Soto, O., et al.: An efficient retinal blood vessel segmentation in eye fundus images by using optimized top-hat and homomorphic filtering. Comput. Methods Programs Biomed. 201, 105949 (2021)
Freund, Y., Schapire, R.E.: A short introduction to boosting. J. Jpn. Soc. Artif. Intell. 14(5), 771–780 (1999)
Breiman, L.: Random forests. Mach. Learn. 45(1), 5–32 (2001)
Azzopardi, G., Strisciuglio, N., Vento, M., Petkov, N.: Trainable COSFIRE filters for vessel delineation with application to retinal images. Med. Image Anal. 19(1), 46–57 (2015)
Liskowski, P., Krawiec, K.: Segmenting retinal blood vessels with deep neural networks. IEEE Trans. Med. Imaging 35(11), 2369–2380 (2016)
Li, Q., Feng, B., Xie, L., Liang, P., Zhang, H., Wang, T.: A cross-modality learning approach for vessel segmentation in retinal images. IEEE Trans. Med. Imaging 35(1), 109–118 (2016)
Orlando, J.I., Prokofyeva, E., Blaschko, M.B.: A discriminatively trained fully connected conditional random field model for blood vessel segmentation in fundus images. IEEE. Trans. Biomed. Eng. 64(1), 16–27 (2017)
Yan, Z., Yang, X., Cheng, K.T.: Joint segment-level and pixel-wise losses for deep learning based retinal vessel segmentation. IEEE. Trans. Biomed. Eng. 65(9), 1912–1923 (2018)
Wu, Y., Xia, Y., Song, Y., Zhang, Y., Cai, W.: Multiscale network followed network model for retinal vessel segmentation. In: Frangi, A.F., Schnabel, J.A., Davatzikos, C., Alberola-López, C., Fichtinger, G. (eds.) MICCAI 2018. LNCS, vol. 11071, pp. 119–126. Springer, Cham (2018). https://doi.org/10.1007/978-3-030-00934-2_14
Acknowledgments
This work was supported by the National Natural Science Foundation of China (62106208), the Sichuan Science and Technology Program (2020JDRC0031) and the China Postdoctoral Science Foundation (2021TQ0272, 2021M702715).
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Deng, T., Huang, Y., Zhang, J. (2022). MLFF: Multiple Low-Level Features Fusion Model for Retinal Vessel Segmentation. In: Pan, L., Cui, Z., Cai, J., Li, L. (eds) Bio-Inspired Computing: Theories and Applications. BIC-TA 2021. Communications in Computer and Information Science, vol 1566. Springer, Singapore. https://doi.org/10.1007/978-981-19-1253-5_20
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DOI: https://doi.org/10.1007/978-981-19-1253-5_20
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