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Membrane Cofactor Protein

  • Chapter
Membrane Defenses Against Attack by Complement and Perforins

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 178))

Abstract

Membrane cofactor protein (MCP, CD46) is a widely distributed regulatory protein that inhibits complement activation on host cells. Except for erythrocytes, it has been found on every cell examined (Liszewski et al. 1991 ). Cole et al. (1985) originally identified MCP as a third class, in addition to CR1 and CR2, of electrophoretically distinct, C3 binding, membrane proteins of human peripheral blood leukocytes. Initially termed gp45–70, to reflect its electrophoretic mobility on SDS-PAGE, the common name was changed to MCP when its cofactor activity was recognized (Seya et al. 1986). MCP was hypothesized and subsequently found to belong to a family of structurally, functionally, and genetically related proteins collectively termed the regulators of complement activation (RCA) (DeCordoba et al. 1984, 1985; Holers et al. 1985; Hourcade et al. 1989). Recently, MCP was given its leukocyte differentiation number (CD46) and a monoclonal antibody (E4.3) was designated as the standard typing reagent (Hadam 1990; Purcell et al. 1989a). This chapter will review our current understanding of the structure and function of MCP, emphasizing recent contributions made possible by molecular analyses (Post et al. 1991).

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Authors and Affiliations

  1. Howard Hughes Medical Institute Laboratories, Department of Medicine, Division of Rheumatology, Washington University School of Medicine, 8045, 4566 Scott, St. Louis, MO, 63110, USA

    M. K. Liszewski & J. P. Atkinson

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  1. M. K. Liszewski
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  2. J. P. Atkinson
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Editors and Affiliations

  1. Department of Veterans Affairs Medical Center, University of Utah School of Medicine, Salt Lake City, Utah, 84148, USA

    Charles J. Parker A. B., M.D. (Associate Professor of Medicine, Chief, Hematology Subsection) (Associate Professor of Medicine, Chief, Hematology Subsection)

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Liszewski, M.K., Atkinson, J.P. (1992). Membrane Cofactor Protein. In: Parker, C.J. (eds) Membrane Defenses Against Attack by Complement and Perforins. Current Topics in Microbiology and Immunology, vol 178. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77014-2_4

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  • DOI: https://doi.org/10.1007/978-3-642-77014-2_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77016-6

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