[go: up one dir, main page]
More Web Proxy on the site http://driver.im/
Skip to main content

Methamphetamin

  • Chapter
  • First Online:
Handbuch Psychoaktive Substanzen

Part of the book series: Springer Reference Psychologie ((SRP))

Zusammenfassung

Methamphetamin, (Grundlage des sog. „Crystal Meth“) bewirkt eine subjektiv empfundene Leistungssteigerung, eine Reduktion körperlicher und psychischer Müdigkeitserscheinungen sowie Euphorie. Seine Wirkung entfaltet es zentralnervös hauptsächlich über eine Konzentrationserhöhung von Noradrenalin und Dopamin im synaptischen Spalt.

Obwohl Methamphetamin keine neue Substanz ist, spielt es aufgrund der wachsenden Verbreitung in unserem Gesundheitssystem eine immer größere Rolle und erhält zunehmend mediale Aufmerksamkeit.

Es wird von einem breiten Spektrum von Konsumenten mit sehr unterschiedlichen Konsummotivationen eingenommen, darunter zur Leistungssteigerung am Arbeitsplatz, zur Bewältigung von Alltagssituationen und in bestimmten Teilen der Partyszene.

Schäden bei langfristigem Konsum betreffen mehrere Organsysteme und die Neurotoxizität führt zu deutlichen Defiziten in kognitiven Funktionen. Exzessive Gebrauchsmuster führen häufig zu psychiatrischen Symptombildern wie der sog. Amphetaminpsychose.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
£29.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
GBP 19.95
Price includes VAT (United Kingdom)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
GBP 109.50
Price includes VAT (United Kingdom)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
GBP 109.99
Price includes VAT (United Kingdom)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

Literatur

  • Adlersberg, D., & Mayer, M. E. (1949). Results of prolonged medical treatment of obesity with diet alone, diet and thyroid preparations, and diet and amphetamine. Journal of Clinical Endocrinology and Metabolism, 9(3), 275–284.

    Article  PubMed  Google Scholar 

  • Aron, J. L., & Paulus, M. P. (2007). Location, location: Using functional magnetic resonance imaging to pinpoint brain differences relevant to stimulant use. Addiction, 102(Suppl 1), 33–43.

    Article  PubMed  Google Scholar 

  • Baicy, K., & London, E. D. (2007). Corticolimbic dysregulation and chronic methamphetamine abuse. Addiction, 102(Suppl 1), 5–15.

    Article  PubMed  Google Scholar 

  • Barr, A. M., Panenka, W. J., MacEwan, G. W., Thornton, A. E., Lang, D. J., Honer, W. G., et al. (2006). The need for speed: An update on methamphetamine addiction. Journal of Psychiatry and Neuroscience, 31(5), 301–313.

    Google Scholar 

  • Berman, S., O'Neill, J., Fears, S., Bartzokis, G., & London, E. D. (2008). Abuse of amphetamines and structural abnormalities in the brain. Annals of the New York Academy of Sciences, 1141, 195–220.

    Article  PubMed  PubMed Central  Google Scholar 

  • Berman, S. M., Voytek, B., Mandelkern, M. A., Hassid, B. D., Isaacson, A., Monterosso, J., et al. (2008). Changes in cerebral glucose metabolism during early abstinence from chronic methamphetamine abuse. Molecular Psychiatry, 13(9), 897–908.

    Google Scholar 

  • BKA. (2014). Synthetische Drogen auf dem Vormarsch – Drogenbeauftragte der Bundesregierung und BKA-Präsident stellen die Rauschgiftlage und die Zahlen der Drogentoten 2014 vor. Bundeskriminalamt.

    Google Scholar 

  • BMJV. (2001). Gesetz über den Verkehr mit Betäubungsmitteln (Betäubungsmittelgesetz – BtMG) Anlage II (zu § 1 Abs. 1, verkehrsfähige, aber nicht verschreibungsfähige Betäubungsmittel). B. d. J. u. f. Verbraucherschutz.

    Google Scholar 

  • Brandon, S., & Smith, D. (1962). Amphetamines in general practice. The Journal of the College of General Practitioners, 5, 603–606.

    PubMed  PubMed Central  Google Scholar 

  • Brensilver, M., Heinzerling, K. G., & Shoptaw, S. (2013). Pharmacotherapy of amphetamine-type stimulant dependence: An update. Drug and Alcohol Review, 32(5), 449–460.

    PubMed  PubMed Central  Google Scholar 

  • Caldwell, J., Dring, L. G., & Williams, R. T. (1972). Metabolism of (14 C)methamphetamine in man, the guinea pig and the rat. Biochemical Journal, 129(1), 11–22.

    Article  PubMed  PubMed Central  Google Scholar 

  • Chiu, C. T., Ma, T., & Ho, I. K. (2006). Methamphetamine-induced behavioral sensitization in mice: Alterations in mu-opioid receptor. Journal of Biomedical Science, 13(6), 797–811.

    Article  PubMed  PubMed Central  Google Scholar 

  • Cho, A. K., & Melega, W. P. (2002). Patterns of methamphetamine abuse and their consequences. Journal of Addictive Diseases, 21(1), 21–34.

    Article  PubMed  Google Scholar 

  • Ciccarone, D. (2011). Stimulant abuse: Pharmacology, cocaine, methamphetamine, treatment, attempts at pharmacotherapy. Primary Care, 38(1), 41–58. v-vi.

    Article  PubMed  PubMed Central  Google Scholar 

  • Colfax, G. N., Santos, G. M., Das, M., Santos, D. M., Matheson, T., Gasper, J., et al. (2011). Mirtazapine to reduce methamphetamine use: A randomized controlled trial. Archives of General Psychiatry, 68(11), 1168–1175.

    Google Scholar 

  • Comer, S. D., Mogali, S., Saccone, P. A., Askalsky, P., Martinez, D., Walker, E. A., et al. (2013). Effects of acute oral naltrexone on the subjective and physiological effects of oral D-amphetamine and smoked cocaine in cocaine abusers. Neuropsychopharmacology, 38(12), 2427–2438.

    Google Scholar 

  • Courtney, K. E., & Ray, L. A. (2014). Methamphetamine: An update on epidemiology, pharmacology, clinical phenomenology, and treatment literature. Drug and Alcohol Dependence, 143, 11–21.

    Article  PubMed  Google Scholar 

  • Cruickshank, C. C., & Dyer, K. R. (2009). A review of the clinical pharmacology of methamphetamine. Addiction, 104(7), 1085–1099.

    Article  PubMed  Google Scholar 

  • Drug Enforcement Administration. (2016). Drug scheduling. Drug Enforcement Administration. Virginia, USA: Springfield.

    Google Scholar 

  • Dean, A. C., Groman, S. M., Morales, A. M., & London, E. D. (2013). An evaluation of the evidence that methamphetamine abuse causes cognitive decline in humans. Neuropsychopharmacology, 38(2), 259–274.

    Article  PubMed  Google Scholar 

  • Die Drogenbeauftragte der Bundesregierung, Bundesministerium für Gesundheit (BMG) and Bundesärztekammer (BÄK). (2016). S3-Leitlinie Methamphetamin-bezogene Störungen, Konsultationsfassung.

    Google Scholar 

  • Drug Enforcement Administration. (2014). Final adjusted aggregate production quotas for schedule I and II controlled substances and assessment of annual needs for the list I chemicals ephedrine, pseudoephedrine, and phenylpropanolamine for 2013. DEA. Virginia, USA: Springfield.

    Google Scholar 

  • EMCDDA. (2014). Exploring methamphetamine trends in Europe. Luxembourg: Publications Office of the European Union.

    Google Scholar 

  • EMCDDA. (2015). European drug report. EMCDDA.

    Google Scholar 

  • EMCDDA. (2016). European drug report. EMCDDA.

    Google Scholar 

  • Fester. (2009). Secrets of methamphetamine manufacture. Green Bay: Festering Publications.

    Google Scholar 

  • Ford, C. P., Mark, G. P., & Williams, J. T. (2006). Properties and opioid inhibition of mesolimbic dopamine neurons vary according to target location. The Journal of Neuroscience, 26(10), 2788–2797.

    Article  PubMed  PubMed Central  Google Scholar 

  • Gelvin, E. P., & Mc, G. T. (1949). Dexedrine and weight reduction. New York State Journal of Medicine, 49(3), 279–282.

    PubMed  Google Scholar 

  • Glasner-Edwards, S., & Mooney, L. J. (2014). Methamphetamine psychosis: Epidemiology and management. CNS Drugs, 28(12), 1115–1126.

    Article  PubMed  PubMed Central  Google Scholar 

  • Grinspoon, L., & Hedblom, P. (1976). Speed culture: Amphetamine use and abuse in America. Cambridge, MA: Harvard University Press.

    Google Scholar 

  • Groman, S. M., Lee, B., Seu, E., James, A. S., Feiler, K., Mandelkern, M. A., et al. (2012). Dysregulation of D(2)-mediated dopamine transmission in monkeys after chronic escalating methamphetamine exposure. The Journal of Neuroscience, 32(17), 5843–5852.

    Google Scholar 

  • Herbeck, D. M., Brecht, M. L., & Lovinger, K. (2015). Mortality, causes of death and health status among methamphetamine users. Journal of Addictive Diseases, 34(1), 88–100.

    Article  PubMed  Google Scholar 

  • Herman-Stahl, M. A., Krebs, C. P., Kroutil, L. A., & Heller, D. C. (2007). Risk and protective factors for methamphetamine use and nonmedical use of prescription stimulants among young adults aged 18 to 25. Addictive Behaviors, 32(5), 1003–1015.

    Article  PubMed  Google Scholar 

  • Hermens, D. F., Lubman, D. I., Ward, P. B., Naismith, S. L., & Hickie, I. B. (2009). Amphetamine psychosis: A model for studying the onset and course of psychosis. The Medical Journal of Australia, 190(4 Suppl), S22–S25.

    PubMed  Google Scholar 

  • Hillemacher, T., Kornhuber, J., & Bleich, S. (2007). Neurobiological mechanisms and pharmacological treatment options for alcohol craving. Fortschritte der Neurologie-Psychiatrie, 75(1), 26–32.

    Article  PubMed  Google Scholar 

  • Homer, B. D., Solomon, T. M., Moeller, R. W., Mascia, A., DeRaleau, L., & Halkitis, P. N. (2008). Methamphetamine abuse and impairment of social functioning: A review of the underlying neurophysiological causes and behavioral implications. Psychological Bulletin, 134(2), 301–310.

    Article  PubMed  Google Scholar 

  • Iversen, L. (2005). Speed, ecstasy, ritalin. Oxford: Oxford University Press.

    Google Scholar 

  • Jayaram-Lindstrom, N., Wennberg, P., Hurd, Y. L., & Franck, J. (2004). Effects of naltrexone on the subjective response to amphetamine in healthy volunteers. Journal of Clinical Psychopharmacology, 24(6), 665–669.

    Article  PubMed  Google Scholar 

  • Karila, L., Weinstein, A., Aubin, H. J., Benyamina, A., Reynaud, M., & Batki, S. L. (2010). Pharmacological approaches to methamphetamine dependence: A focused review. British Journal of Clinical Pharmacology, 69(6), 578–592.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kiefer, F., & Wiedemann, K. (2004). Neuroendocrine pathways of addictive behaviour. Addiction Biology, 9(3–4), 205–212.

    Article  PubMed  Google Scholar 

  • Kiloh, L. G., & Brandon, S. (1962). Habituation and addiction to amphetamines. British Medical Journal, 2(5296), 40–43.

    Article  PubMed  PubMed Central  Google Scholar 

  • Lee, N. K., & Rawson, R. A. (2008). A systematic review of cognitive and behavioural therapies for methamphetamine dependence. Drug and Alcohol Review, 27(3), 309–317.

    Article  PubMed  PubMed Central  Google Scholar 

  • London, E. D., Simon, S. L., Berman, S. M., Mandelkern, M. A., Lichtman, A. M., Bramen, J., et al. (2004). Mood disturbances and regional cerebral metabolic abnormalities in recently abstinent methamphetamine abusers. Archives of General Psychiatry, 61(1), 73–84.

    Google Scholar 

  • McKetin, R., Kelly, E., & McLaren, J. (2006). The relationship between crystalline methamphetamine use and methamphetamine dependence. Drug and Alcohol Dependence, 85(3), 198–204.

    Article  PubMed  Google Scholar 

  • McKetin, R., Ross, J., Kelly, E., Baker, A., Lee, N., Lubman, D. I., et al. (2008). Characteristics and harms associated with injecting versus smoking methamphetamine among methamphetamine treatment entrants. Drug and Alcohol Review, 27(3), 277–285.

    Google Scholar 

  • Meredith, C. W., Jaffe, C., Ang-Lee, K., & Saxon, A. J. (2005). Implications of chronic methamphetamine use: A literature review. Harvard Review of Psychiatry, 13(3), 141–154.

    Article  PubMed  Google Scholar 

  • Nestor, L. J., Ghahremani, D. G., Monterosso, J., & London, E. D. (2011). Prefrontal hypoactivation during cognitive control in early abstinent methamphetamine-dependent subjects. Psychiatry Research, 194(3), 287–295.

    Article  PubMed  PubMed Central  Google Scholar 

  • Pabst, A., Kraus, L., Gomes de Matos, E., & Piontek, D. (2013). Substanzkonsum und substanzbezogene Störungen in Deutschland im Jahr 2012. SUCHT, 59(6), 321–331.

    Article  Google Scholar 

  • Patzak, J., & Bohnen, W. (2010). Betäubungsmittelrecht. München: C.H. Beck.

    Google Scholar 

  • Paulus, M. P., Hozack, N., Frank, L., Brown, G. G., & Schuckit, M. A. (2003). Decision making by methamphetamine-dependent subjects is associated with error-rate-independent decrease in prefrontal and parietal activation. Biological Psychiatry, 53(1), 65–74.

    Article  PubMed  Google Scholar 

  • Paulus, M. P., Tapert, S. F., & Schuckit, M. A. (2005). Neural activation patterns of methamphetamine-dependent subjects during decision making predict relapse. Archives of General Psychiatry, 62(7), 761–768.

    Article  PubMed  Google Scholar 

  • Piontek, D., Pfeiffer-Gerschel, T., Jakob, L., Pabst, A., & Kraus, L. (2013). Sekundäranalysen im Rahmen des Projekts „Missbrauch von Amphetaminen in Deutschland: Studie zur Motivation und zu den Konsumgewohnheiten von missbräuchlich Amphetaminkonsumierenden. B. f. Gesundheit. Bern: Hogrefe AG.

    Google Scholar 

  • Rasmussen, N. (2008). America’s first amphetamine epidemic 1929–1971. American Journal of Public Health, 98(6), 974–985.

    Article  PubMed  PubMed Central  Google Scholar 

  • Rasmussen, N. (2015). Amphetamine-type stimulants: The early history of their medical and non-medical uses. International Review of Neurobiology, 120, 9–25.

    Article  PubMed  Google Scholar 

  • Recordati Rare Diseases Inc. (2013). Medication guide – Desoxyn. Lebanon: Food and Drug Administration.

    Google Scholar 

  • Rusyniak, D. E. (2013). Neurologic manifestations of chronic methamphetamine abuse. The Psychiatric Clinics of North America, 36(2), 261–275.

    Article  PubMed  PubMed Central  Google Scholar 

  • Salamanca, S. A., Sorrentino, E. E., Nosanchuk, J. D., & Martinez, L. R. (2014). Impact of methamphetamine on infection and immunity. Frontiers in Neuroscience, 8, 445.

    PubMed  Google Scholar 

  • Salo, R., Fassbender, C., Buonocore, M. H., & Ursu, S. (2013). Behavioral regulation in methamphetamine abusers: An fMRI study. Psychiatry Research, 211(3), 234–238.

    Article  PubMed  Google Scholar 

  • Scott, J. C., Woods, S. P., Matt, G. E., Meyer, R. A., Heaton, R. K., Atkinson, J. H., et al. (2007). Neurocognitive effects of methamphetamine: A critical review and meta-analysis. Neuropsychology Review, 17(3), 275–297.

    Google Scholar 

  • Sekine, Y., Ouchi, Y., Takei, N., Yoshikawa, E., Nakamura, K., Futatsubashi, M., et al. (2006). Brain serotonin transporter density and aggression in abstinent methamphetamine abusers. Archives of General Psychiatry, 63(1), 90–100.

    Google Scholar 

  • Thomasius, R., Gouzoulis-Mayfrank, E., Karus, C., Wiedenmann, H., Hermle, L., Sack, P. M., et al. (2004). AWMF-Behandlungsleitlinie: Psychische und Verhaltensstörungen durch Kokain, Amphetamine, Ecstasy und Halluzinogene. Fortschritte der Neurologie-Psychiatrie, 72(12), 679–695.

    Google Scholar 

  • Thompson, P. M., Hayashi, K. M., Simon, S. L., Geaga, J. A., Hong, M. S., Sui, Y., et al. (2004). Structural abnormalities in the brains of human subjects who use methamphetamine. The Journal of Neuroscience, 24(26), 6028–6036.

    Google Scholar 

  • Tiihonen, J., Krupitsky, E., Verbitskaya, E., Blokhina, E., Mamontova, O., Fohr, J., et al. (2012). Naltrexone implant for the treatment of polydrug dependence: A randomized controlled trial. The American Journal of Psychiatry, 169(5), 531–536.

    Google Scholar 

  • Ujike, H., & Sato, M. (2004). Clinical features of sensitization to methamphetamine observed in patients with methamphetamine dependence and psychosis. Annals of the New York Academy of Sciences, 1025, 279–287.

    Article  PubMed  Google Scholar 

  • UNODC. (2011). http://www.unodc.org/documents/ATS/ATS_Global_Assessment_2011.pdf.

  • Vocci, F. J., & Appel, N. M. (2007). Approaches to the development of medications for the treatment of methamphetamine dependence. Addiction, 102(Suppl 1), 96–106.

    Article  PubMed  Google Scholar 

  • Volkow, N. D., Chang, L., Wang, G. J., Fowler, J. S., Franceschi, D., Sedler, M., et al. (2001a). Loss of dopamine transporters in methamphetamine abusers recovers with protracted abstinence. The Journal of Neuroscience, 21(23), 9414–9418.

    Google Scholar 

  • Volkow, N. D., Chang, L., Wang, G. J., Fowler, J. S., Franceschi, D., Sedler, M. J., et al. (2001b). Higher cortical and lower subcortical metabolism in detoxified methamphetamine abusers. The American Journal of Psychiatry, 158(3), 383–389.

    Google Scholar 

  • Volkow, N. D., Chang, L., Wang, G. J., Fowler, J. S., Leonido-Yee, M., Franceschi, D., et al. (2001c). Association of dopamine transporter reduction with psychomotor impairment in methamphetamine abusers. The American Journal of Psychiatry, 158(3), 377–382.

    Google Scholar 

  • Yu, S., Zhu, L., Shen, Q., Bai, X., & Di, X. (2015). Recent advances in methamphetamine neurotoxicity mechanisms and its molecular pathophysiology. Behavioural Neurology, 2015, 103969.

    PubMed  PubMed Central  Google Scholar 

  • Zorick, T., Nestor, L., Miotto, K., Sugar, C., Hellemann, G., Scanlon, G., et al. (2010). Withdrawal symptoms in abstinent methamphetamine-dependent subjects. Addiction, 105(10), 1809–1818.

    Google Scholar 

  • Zuloaga, D. G., Jacobskind, J. S., & Raber, J. (2015). Methamphetamine and the hypothalamic-pituitary-adrenal axis. Frontiers in Neuroscience, 9, 178.

    PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Felix Betzler .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer-Verlag GmbH Deutschland

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Betzler, F., Köhler, S. (2018). Methamphetamin. In: von Heyden, M., Jungaberle, H., Majić, T. (eds) Handbuch Psychoaktive Substanzen. Springer Reference Psychologie . Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55125-3_67

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-55125-3_67

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-55124-6

  • Online ISBN: 978-3-642-55125-3

  • eBook Packages: Psychology (German Language)

Publish with us

Policies and ethics