Abstract
We perform comparisons among protein sequences based on a 3-D graphic representation of proteins [Bai and Wang, J. Biomol. Struc. Dyn., 23, 537–545 (2006)]. In detail, we make analysis of similarities among nine ATP6(ATP synthase F0 subunit 6) proteins by comparing their corresponding 3-D curves and select the geometric center and the correlation matrix from the 3-D curve, as well as a angle metric for the construction of the phylogenetic tree. In comparison with the traditional alignments of sequences, the proposed method does not require multiple alignment and conceptually and computationally it is rather simple.
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Acknowledgments
We are indebted to both referees for their many valuable suggestions and comments, which are critical for improving the quality of the manuscript. This work is supported by the Science and Technology Development Program of Henan Province, China (Grant No. 102300410216).
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Liu, Y., Yang, Yc., Wang, Tm. (2015). Comparative Studies Based on a 3-D Graphical Representation of Protein Sequences. In: Huang, DS., Jo, KH., Hussain, A. (eds) Intelligent Computing Theories and Methodologies. ICIC 2015. Lecture Notes in Computer Science(), vol 9226. Springer, Cham. https://doi.org/10.1007/978-3-319-22186-1_43
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