Abstract
Bivalent promoters are defined by the presence of both activating (H3K4me3) and repressive (H3K27me3) chromatin marks. In this paper, we first identified high confidence bivalent promoters in murine ES cells integrating data across eight studies using two methods; peak-based and cutoff-based. We showed that peak-based method is more reliable as promoters are more enriched for developmental regulators than the cutoff-based method. We further identified bivalent promoters in human and pig using the peak-based method to show that the bivalent promoters conserved across species were highly enriched for embryonic developmental processes.
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Mantsoki, A., Joshi, A. (2015). Comparative Analysis of Bivalent Domains in Mammalian Embryonic Stem Cells. In: Ortuño, F., Rojas, I. (eds) Bioinformatics and Biomedical Engineering. IWBBIO 2015. Lecture Notes in Computer Science(), vol 9043. Springer, Cham. https://doi.org/10.1007/978-3-319-16483-0_39
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DOI: https://doi.org/10.1007/978-3-319-16483-0_39
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-16482-3
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