Abstract
Locally advanced non-small cell lung cancer (NSCLC) is characterized by poor prognosis and is the leading cause of cancer-related deaths worldwide. The main problem in NSCLC is treatment resistance and a high potential for progression and metastasis, which results in low survival rates for patients. Immunotherapy (IO) alone or combined with chemotherapy and targeted therapies, while dedicated to selective subgroups of patients, replaced traditional cytotoxic therapies (radiotherapy or chemotherapy) in advanced stages of disease. Therefore, it’s important to search for new features that may help predict the effectiveness of currently available therapies. The paper presents preliminary results of exploratory data and survival analyses (Kaplan-Meier survival curves, uni- and multivariate Cox proportional hazards models), indicating potential factors that may help stratify the group of patients to select the appropriate treatment.
S. Gałecki and M. Gałecki have contributed equally.
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References
Didkowska J., Wojciechowska U., Olasek P., Caetano dos Santos F., Michałek I.: Nowotwory złośliwe w Polsce w 2019 roku. ISSN 0867-8251, Warszawa (2021)
Kozłowska, E., Giglok, M., Dȩbosz-Suwińska, I., Suwiński, R., Świerniak, A.: Predicting metastasis-Free survival using clinical data in non-small cell lung. Recent Challenges in Intelligent Information and Database Systems: 14th Asian Conference, ACIIDS,: Ho Chi Minh City, Vietnam, November 28–30, 2022. Proceedings cancer, pp. 227–237 (2022)
Sung, H., Ferlay, J., Siegel, R.L., Laversanne, M., Soerjomataram, I., Jemal, A., Bray, F.: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71(3), 209–249 (2021)
Popper, H.H.: Progression and metastasis of lung cancer. Cancer Metastasis Rev. 35(1), 75–91 (2016)
Kutkowska, J., Porȩbska, I., Rapak, A.: Non-small cell lung cancer - mutations, targeted and combination therapy. Postepy Higieny i Medycyny Doświadczalnej 71, 431–445 (2017)
Krzakowski, M., Jassem, J.: Nowotwory płuca i opłucnej oraz śródpiersia. Onkologia w Praktyce Klinicznej - Edukacja 5(1), 21–53 (2019)
Sierko E., Wojtukiewicz M.: Patofizjologiczne podstawy terapii ukierunkowanej na zahamowanie funkcji receptora czynnika wzrostu naskórka (EGFR). Onkologia w Praktyce Klinicznej, T. 6, nr 5, s. 217–227 (2010)
Chaitanya, T.K., Barsouk, A., Saginala, K., Sukumar, A.J., Barsouk, A.: Epidemiology of lung cancer. Contemporary Oncology/Współczesna Onkologia 25(1), 45–52 (2021)
Zyśk, R., Krzakowski, M.: Personalised treatment of non-small-cell lung cancer patients—review of current evidence. Oncol. Clin. Pract. 14, 23–34 (2018)
Butkiewicz, D., Krześniak, M., Gdowicz-Kłosok, A., Giglok, M., Marszałek-Zeńczak, M., Suwiński, R.: Polymorphisms in EGFR gene predict clinical outcome in unresectable non-small cell lung cancer treated with radiotherapy and platinum-based chemoradiotherapy. Int. J. Mol. Sci. 22(11), 5605 (2021)
Shen, H.B., Li, J., Yao, Y.S., Yang, Z.H., Zhou, Y.J., Chen, W., Hu, T.J.: Impact of somatic mutations in non-small-cell lung cancer: a retrospective study of a chinese cohort. Cancer Manag. Res. 19(12), 7427–7437 (2020). Aug
Kawaguchi, T., Takada, M., Kubo, A., Matsumura, A., Fukai, S., Tamura, A., Saito, R., Maruyama, Y., Kawahara, M., Ignatius, Ou.S., H.: Performance status and smoking status are independent favorable prognostic factors for survival in non-small cell lung cancer: a comprehensive analysis of 26,957 patients with NSCLC. J. Thorac. Oncol. 5(5), 620–630 (2010)
Acknowledgements
This work was supported by the National Science Centre (NCN), Poland, grant no. 2020/37/B/ST6/01959 (AS, EK, SG, and AMW). The presented results and their interpretation will be part of Marzena Kysiak’s doctoral dissertation.
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Gałecki, S., Kysiak, M., Kozłowska, E., Wilk, A.M., Suwiński, R., Świerniak, A. (2024). Assessing the Prognosis of Patients with Metastatic or Recurrent Non-small Cell Lung Cancer in the Era of Immunotherapy and Targeted Therapy. In: Strumiłło, P., Klepaczko, A., Strzelecki, M., Bociąga, D. (eds) The Latest Developments and Challenges in Biomedical Engineering. PCBEE 2023. Lecture Notes in Networks and Systems, vol 746. Springer, Cham. https://doi.org/10.1007/978-3-031-38430-1_14
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