Abstract
This paper presents a study on a Lab-on-Chip system based on the optical interaction between biological material and optical devices for the detection of analyte’s properties inside a solution or mixture. The reported LoC performs both interaction and detection phase in the same chip, taking advantage of a polymer waveguiding structure optically coupled with a thin-film amorphous silicon photodiode fabricated on a single glass substrate. Before its actual implementation in biomolecular recognition applications, we report a feasibility study on the detection of fat content in milk, carried out by interpolating simulated data with the measured electro-optical response of the sensor. The sensing demonstration highlights a limit of detection of 106 ppm and a sensitivity of about 8.7 pA/(g/dL), encouraging further developments and an actual implementation in food quality control.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Vurchio, F., et al.: Grasping and releasing agarose micro beads in water drops. Micromachines 10(7), 436 (2019)
Buzzin, A., Veroli, A., Alam, B., Maiolo, L., Marrani, M., Muzi, M.: Polymer nano-sieve for particle filtering in lab-on-chip devices. In: AIP Conference Proceedings, vol. 2145, no. 1, p. 020013. AIP Publishing LLC (2019)
Luisetto, I., et al.: An interdisciplinary approach to the nanomanipulation of SiO2 nanoparticles: design, fabrication and feasibility. Appl. Sci. 8, 2645 (2018)
Duncombe, T.A., Tentori, A.M., Herr, A.E.: Microfluidics: reframing biological enquiry. Nat. Rev. Mol. Cell Biol. 16(9), 554–567 (2015)
Monosik, R., Stredansky, M., Sturdik, E.: Biosensors - classification, characterization and new trends. Acta chimica slovaca 5(1), 109–120 (2012)
Kaushik, A., Mujawar, M.A.: Point of care sensing devices: better care for everyone. Sensors 18(12), 4303 (2018)
Buzzin, A., et al.: Integrated 3D microfluidic device for impedance spectroscopy in lab-on-chip systems. In: 2019 IEEE 8th International Workshop on Advances in Sensors and Interfaces (IWASI), pp. 224–227. IEEE (2019)
Srinivasan, B., Tung, S.: Development and applications of portable biosensors. J. Lab. Autom. 20(4), 365–389 (2015)
Fan, X., White, I.M., Shopova, S.I., Zhu, H., Suter, J.D., Sun, Y.: Sensitive optical biosensors for unlabeled targets: a review. Anal. Chim. Acta 620(1–2), 8–26 (2008)
Laschuk, N.O., et al.: Rational design of a material for rapid colorimetric Fe2+ detection. Mater. Des. 107, 18–25 (2016)
Veroli, A., et al.: High circular dichroism and robust performance in planar plasmonic metamaterial made of nano-comma-shaped resonators. JOSA B 36(11), 3079–3084 (2019)
Bozhevolnyi, S.I., Volkov, V.S., Devaux, E., Laluet, J.Y., Ebbesen, T.W.: Channel plasmon subwavelength waveguide components including interferometers and ring resonators. Nature 440(7083), 508–511 (2006)
Anker, J.N., Hall, W.P., Lyandres, O., Shah, N.C., Zhao, J., Van Duyne, R.P.: Biosensing with plasmonic nanosensors. Nanosci. Technol. Collect. Rev. Nat. J. 308–319 (2010)
Asquini, R., Buzzin, A., Caputo, D., de Cesare, G.: Integrated evanescent waveguide detector for optical sensing. IEEE Trans. Compon. Packaging Manuf. Technol. 8(7), 1180–1186 (2018)
Buzzin, A., Asquini, R., Caputo, D., de Cesare, G.: On-glass integrated SU-8 waveguide and amorphous silicon photosensor for on-chip detection of biomolecules: feasibility study on hemoglobin sensing. Sensors 21(2), 415 (2021)
Salgueiro, L., Martins, A.P., Correia, H.: Raw materials: the importance of quality and safety. A review. Flavour Fragr. J. 25(5), 253–271 (2010)
Nascimento, C.F., Santos, P.M., Pereira-Filho, E.R., Rocha, F.R.: Recent advances on determination of milk adulterants. Food Chem. 221, 1232–1244 (2017)
Savi, P., Naishadham, K., Quaranta, S., Giorcelli, M., Bayat, A., Ramella, C.: Design of a graphene-loaded slotted ring resonator for sensor applications. In: IEEE European Conference on Antennas and Propagation (EUCAP), pp. 2564–2567 (2017)
Alam, B., Veroli, A., Caló, G., Petruzzelli, V., Benedetti, A.: Multilayer optical routing by means of vertical directional coupler with long range surface plasmons. AIP Conf. Proc. 2145(1), 020017 (2019)
Gizzi, C., Asquini, R., d’Alessandro, A.: A polarization independent liquid crystal assisted vertical coupler switch. Mol. Cryst. Liq. Cryst. 421, 95–105 (2004)
Wang, C., Cho, S.J., Kim, N.Y.: SU-8-based structural material for microelectronic processing applications. Mater. Manuf. Process. 28(8), 947–952 (2013)
de Cesare, G., Nascetti, A., Caputo, D.: Amorphous silicon p-i-n structure acting as light and temperature sensor. Sensors 15, 12260–12272 (2015)
Tucci, M., Serenelli, L., De Iuliis, S., Izzi, M., de Cesare, G., Caputo, D.: Back contact formation for p-type based a-Si:H/c-Si heterojunction solar cells. Phys. Status Solidi (C) 8, 932–935 (2011)
Nathan, A., Kumar, A., Sakariya, K., Servati, P., Sambandan, S., Striakhilev, D.: Amorphous silicon thin film transistor circuit integration for organic LED displays on glass and plastic. IEEE J. Solid-State Circuits 39, 1477–1486 (2004)
Buzzin, A. Cupo, S., Giovine, E., de Cesare, G., Belfiore, N.P.: Compliant nano-pliers as a biomedical tool at the nanoscale: design, simulation and fabrication. Micromachines 11, 1087 (2020)
Calhoun, W.R., Maeta, H., Roy, S., Bali, L.M., Bali, S.: Sensitive real-time measurement of the refractive index and attenuation coefficient of milk and milk-cream mixtures. J. Dairy Sci. 93(8), 3497–3504 (2010)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this paper
Cite this paper
Buzzin, A., Asquini, R., Caputo, D., de Cesare, G. (2023). Amorphous Silicon Based Biosensor for Food Quality Assessment: Feasibility Study on Milk’s Fat Content. In: Di Francia, G., Di Natale, C. (eds) Sensors and Microsystems. AISEM 2021. Lecture Notes in Electrical Engineering, vol 918. Springer, Cham. https://doi.org/10.1007/978-3-031-08136-1_2
Download citation
DOI: https://doi.org/10.1007/978-3-031-08136-1_2
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-08135-4
Online ISBN: 978-3-031-08136-1
eBook Packages: EngineeringEngineering (R0)