Abstract
An early detection of neurodegenerative diseases, such as Parkinson’s disease, can improve therapy effectiveness and, by consequence, the patient’s quality of life. This paper proposes a new methodology for automatic classification of voice samples regarding the presence of acoustic patterns of Parkinson’s disease, using a deep structured neural network. This is a low cost non-invasive approach that can raise alerts in a pre-clinical stage. Aiming to a higher diagnostic detail, it is also an objective to accurately estimate the stage of evolution of the disease allowing to understand in what extent the symptoms have developed. Therefore, two types of classification problems are explored: binary classification and multiclass classification. For binary classification, a deep structured neural network was developed, capable of correctly diagnosing 93.4% of cases. For the multiclass classification scenario, in addition to the deep neural network, a K-nearest neighbour algorithm was also used to establish a reference for comparison purposes, while using a common database. In both cases the original feature set was optimized using principal component analysis and the results showed that the proposed deep structure neural network was able to provide more accurate estimations about the disease’s stage, reaching a score of 84.7%. The obtained results are promising and create the motivation to further explore the model’s flexibility and to pursue better results.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Ho, A.K., Iansek, R., Marigliani, C., Bradshaw, J.L., Gates, S.: Speech impairment in a large sample of patients with Parkinson’s disease. Behav. Neurol. 11, 131–137 (1998)
Ramig, L.O., Fox, C., Sapir, S.: Speech treatment for Parkinson’s disease. Expert Rev. Neurother. 8, 297–309 (2008)
Khemphila, A., Boonjing, V.: Parkinsons disease classification using neural network and feature selection. Int. J. Math. Phys. Electr. Comput. Eng. 6, 377–380 (2012)
Hirsch, L., Jette, N., Frolkis, A., Steeves, T., Pringsheim, T.: The incidence of Parkinson’s disease: a systematic review and meta-analysis. Neuroepidemiology 46, 292–300 (2016)
Neurological disorders: public health challenges. World Health Organization (2006)
Müller, J., Wenning, G.K., Verny, M., McKee, A., Chaudhuri, K.R., Jellinger, K., Poewe, W., Litvan, I.: Progression of dysarthria and dysphagia in postmortem-confirmed parkinsonian disorders. Arch. Neurol. 58, 259–264 (2001)
Liu, L., Luo, X.-G., Dy, C.-L., Ren, Y., Feng, Y., Yu, H.-M., Shang, H., He, Z.-Y.: Characteristics of language impairment in Parkinson’s disease and its influencing factors. Transl. Neurodegener. 4, 2 (2015)
Teixeira, J., Soares, L., Martins, P., Coelho, L., Lopes, C.: Towards an objective criteria for the diagnosis of Parkinson disease based on speech assessment. Presented at the XXXV Congresso Anual de la Sociedad Espanola de Ingenierıa Biomedica, Bilbao (2017)
Norel, R., Agurto, C., Rice, J.J., Ho, B.K., Cecchi, G.A.: Speech-based identification of L-DOPA ON/OFF state in Parkinson’s Disease subjects. BioRxiv Prepr. 420422 (2018)
Zhang, Y.N.: Can a smartphone diagnose Parkinson disease? A deep neural network method and telediagnosis system implementation. Park. Dis. (2017)
Braga, D., Madureira, A.M., Coelho, L., Abraham, A.: Neurodegenerative diseases detection through voice analysis. In: Abraham, A., Muhuri, P.K., Muda, A.K., Gandhi, N. (eds.) Hybrid Intelligent Systems, pp. 213–223. Springer, Heidelberg (2018)
LeCun, Y., Bengio, Y., Hinton, G.: Deep learning. Nature 521, 436–444 (2015)
Gil, D., Magnus, J.: Diagnosing Parkinson by using artificial neural networks and support vector machines. Glob. J. Comput. Sci. Technol. 9, 63–71 (2009)
Saloni, R.K., Gupta, A.K.: Detection of Parkinson disease using clinical voice data mining. Int. J. Circuits Syst. Signal Process. 9 (2015)
Tsanas, A., Little, M.A., McSharry, P.E., Spielman, J., Ramig, L.O.: Novel speech signal processing algorithms for high-accuracy classification of Parkinson’s disease. IEEE Trans. Biomed. Eng. 59, 1264–1271 (2012)
Proença, J., Veiga, A., Candeias, S., Lemos, J., Januário, C., Perdigão, F.: Characterizing Parkinson’s disease speech by acoustic and phonetic features. In: Baptista, J., Mamede, N., Candeias, S., Paraboni, I., Pardo, T.A.S., Volpe Nunes, M.d.G. (eds.) Computational Processing of the Portuguese Language, pp. 24–35. Springer, Heidelberg (2014)
Sakar, B.E., Isenkul, M.E., Sakar, C.O., Sertbas, A., Gurgen, F., Delil, S., Apaydin, H., Kursun, O.: Collection and analysis of a Parkinson speech dataset with multiple types of sound recordings. IEEE J. Biomed. Health Inform. 17, 828–834 (2013)
Abadi, M., Agarwal, A., Barham, P., Brevdo, E., Chen, Z., Citro, C., Corrado, G.S., Davis, A., Dean, J., Devin, M., Ghemawat, S., Goodfellow, I., Harp, A., Irving, G., Isard, M., Jia, Y., Jozefowicz, R., Kaiser, L., Kudlur, M., Vasudevan, V., Viegas, F., Vinyals, O., Warden, P., Wattenberg, M., Wicke, M., Yu, Y., Zheng, X.: TensorFlow: Large-Scale Machine Learning on Heterogeneous Distributed Systems. ArXiv160304467 Cs (2016)
Ranzato, M., Poultney, C., Chopra, S., LeCun, Y.: Efficient learning of sparse representations with an energy-based model. In: Proceedings of the 19th International Conference on Neural Information Processing Systems. pp. 1137–1144. MIT Press, Cambridge (2006)
Glorot, X., Bordes, A., Bengio, Y.: Deep sparse rectifier neural networks. In: Proceedings of the 14th International Conference on Artificial Intelligence and Statistics, pp. 315–323. Fort Lauderdale, Florida (2011)
Srivastava, N., Hinton, G., Krizhevsky, A., Sutskever, I., Salakhutdinov, R.: Dropout: a simple way to prevent neural networks from overfitting. J. Mach. Learn. Res. 15, 1929–1958 (2014)
Arlot, S., Celisse, A.: A survey of cross-validation procedures for model selection. Stat. Surv. 4, 40–79 (2010)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this paper
Cite this paper
Sousa, L., Braga, D., Madureira, A., Coelho, L., Renna, F. (2020). Characterizing Parkinson’s Disease from Speech Samples Using Deep Structured Learning. In: Madureira, A., Abraham, A., Gandhi, N., Silva, C., Antunes, M. (eds) Proceedings of the Tenth International Conference on Soft Computing and Pattern Recognition (SoCPaR 2018). SoCPaR 2018. Advances in Intelligent Systems and Computing, vol 942. Springer, Cham. https://doi.org/10.1007/978-3-030-17065-3_14
Download citation
DOI: https://doi.org/10.1007/978-3-030-17065-3_14
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-17064-6
Online ISBN: 978-3-030-17065-3
eBook Packages: Intelligent Technologies and RoboticsIntelligent Technologies and Robotics (R0)