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Influence of the Gut Microbiota with Ageing

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Microbiology and Aging

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References

  1. O'Hara AM, Shanahan F. The gut flora as a forgotten organ. EMBO Rep 2006;7:688–693.

    Article  PubMed  CAS  Google Scholar 

  2. Shanahan F. Host-flora interactions in inflammatory bowel disease. Inflamm Bowel Dis 2004;10(Suppl 1):S16–S24

    Article  PubMed  Google Scholar 

  3. Hooper LV, Wong MH, Thelin A, Hansson L, Falk PG, Gordon JI. Molecular analysis of commensal host-microbial relationships in the intestine. Science 2001;291:881–884.

    Article  CAS  PubMed  Google Scholar 

  4. Cebra JJ. Influences of microbiota on intestinal immune system development. Am J Clin Nutr 1999;69:1046S–1051S.

    CAS  PubMed  Google Scholar 

  5. Shanahan F. The host-microbe interface within the gut. Best Pract Res Clin Gastroenterol 2002;16:915–931.

    Article  PubMed  Google Scholar 

  6. Sartor RB. The influence of normal microbial flora on the development of chronic mucosal inflammation. Res Immunol 1997;148:567–576.

    Article  CAS  PubMed  Google Scholar 

  7. O'Hara AM, O'Regan P, Fanning A, O'Mahony C, MacSharry J, Lyons A, Bienenstock J, O'Mahony L, Shanahan F. Functional modulation of human intestinal epithelial cell responses by Bifidobacterium infantis and Lactobacillus salivarius. Immunology 2006;118:202–215.

    Article  PubMed  CAS  Google Scholar 

  8. Ma D, Forsythe P, Bienenstock J. Live Lactobacillus reuteri is essential for the inhibitory effect on tumor necrosis factor alpha-induced interleukin-8 expression. Infect Immun 2004;72:5308–5314.

    Article  CAS  Google Scholar 

  9. Otte JM, Podolsky DK. Functional modulation of enterocytes by gram-positive and gram-negative microorganisms. Am J Physiol Gastrointest Liver Physiol 2004;286:G613–G626.

    Article  CAS  PubMed  Google Scholar 

  10. Backhed F, Ley RE, Sonnenburg JL, Peterson DA, Gordon JI. Host-bacterial mutualism in the human intestine. Science 2005;307:1915–1920.

    Article  PubMed  CAS  Google Scholar 

  11. Bergman EN. Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. Physiol Rev 1990;70:567–590.

    CAS  PubMed  Google Scholar 

  12. Roediger WE. Utilization of nutrients by isolated epithelial cells of the rat colon. Gastroen-terology 1982;83:424–429.

    CAS  Google Scholar 

  13. O'Keefe SJ. Nutrition and colonic health: the critical role of the microbiota. Curr Opin Gastroenterol 2008;24:51–58.

    Article  PubMed  Google Scholar 

  14. Rajilic-Stojanovic M, Smidt H, de Vos WM. Diversity of the human gastrointestinal tract microbiota revisited. Environ Microbiol 2007;9:2125–2136.

    Article  PubMed  Google Scholar 

  15. Hooper LV, Midtvedt T, Gordon JI. How host-microbial interactions shape the nutrient environment of the mammalian intestine. Annu Rev Nutr 2002;22:283–307.

    Article  CAS  PubMed  Google Scholar 

  16. Xu J, Bjursell MK, Himrod J, Deng S, Carmichael LK, Chiang HC, Hooper LV, Gordon JI. A genomic view of the human-Bacteroides thetaiotaomicron symbiosis. Science 2003;299: 2074–2076.

    Article  CAS  PubMed  Google Scholar 

  17. Sonnenburg JL, Xu J, Leip DD, Chen CH, Westover BP, Weatherford J, Buhler JD, Gordon JI. Glycan foraging in vivo by an intestine-adapted bacterial symbiont. Science 2005;307: 1955–1959.

    Article  CAS  PubMed  Google Scholar 

  18. Crittenden RG, Martinez NR, Playne MJ. Synthesis and utilisation of folate by yoghurt starter cultures and probiotic bacteria. Int J Food Microbiol 2003;80:217–222.

    Article  CAS  PubMed  Google Scholar 

  19. Klipstein FA, Samloff IM. Folate synthesis by intestinal bacteria. Am J Clin Nutr 1966;19:237–246.

    CAS  PubMed  Google Scholar 

  20. Kim TH, Yang J, Darling PB, O'Connor DL. A large pool of available folate exists in the large intestine of human infants and piglets. J Nutr 2004;134:1389–1394.

    CAS  PubMed  Google Scholar 

  21. Wostmann BS. The germfree animal in nutritional studies. Annu Rev Nutr 1981;1:257–279.

    Article  CAS  PubMed  Google Scholar 

  22. Backhed F, Ding H, Wang T, Hooper LV, Koh GY, Nagy A, Semenkovich CF, Gordon JI. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci USA 2004;101:15718–15723.

    Article  PubMed  CAS  Google Scholar 

  23. Ley RE, Backhed F, Turnbaugh P, Lozupone CA, Knight RD, Gordon JI. Obesity alters gut microbial ecology. Proc Natl Acad Sci USA 2005;102:11070–11075.

    Article  CAS  PubMed  Google Scholar 

  24. Ley RE, Turnbaugh PJ, Klein S, Gordon JI. Microbial ecology: human gut microbes associated with obesity. Nature 2006;444:1022–1023.

    Article  CAS  PubMed  Google Scholar 

  25. Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 2006; 444:1027–1031.

    Article  PubMed  Google Scholar 

  26. Montalto M, Curigliano V, Santoro L, Vastola M, Cammarota G, Manna R, Gasbarrini A, Gasbarrini G. Management and treatment of lactose malabsorption. World J Gastroenterol 2006;14:187–191.

    Google Scholar 

  27. Sanders ME. Consideration for use of probiotic bacteria to modulate human health. J Nutr 2000;130:384S–390S.

    CAS  PubMed  Google Scholar 

  28. Suarez FL, Savaiano DA, Levitt MD. Review article: the treatment of lactose intolerance. Aliment Pharmacol Ther 1995;9:589–597.

    Article  CAS  PubMed  Google Scholar 

  29. Taylor GRJ, Williams CM. Effects of probiotics and prebiotics on blood lipids. Br J Nutr 1998;80:S225–S230.

    CAS  PubMed  Google Scholar 

  30. De Smet I, Van Hoorde L, De Saeyer N, Vande Woestyne M, Verstraete W. In vitro study of bile salt hydrolase (BSH) activity of BSH isogenic Lactobacillus plantarum 80 strains and estimation of cholesterol lowering through enhanced BSH activity. Microb Health Dis 1994;7:315–329.

    Article  Google Scholar 

  31. Wong JMW, de Souza R, Kendall CWC, Emam A, Jenkins DJA. Colonic health: fermentation and short chain fatty acids. J Clin Gasteroenterol 2006;40:235–243.

    Article  CAS  Google Scholar 

  32. Coe FL, Parks JH, Asplin JR. The pathogenesis and treatment of kidney stones. N Engl J Med 1992;327:1141–1154.

    Article  CAS  PubMed  Google Scholar 

  33. Kumar R, Ghoshal UC, Singh G, Mittal RD. Infrequency of colonization with Oxalobacter formigenes in inflammatory bowel disease: possible role in renal stone formation. J Gastro-enterol Hepatol 2004;19:1403–1409.

    Article  Google Scholar 

  34. Allison MJ, Cook MH, Milne DB, Gallagher S, Calyman RV. Oxalate degradation by gastrointestinal bacteria from humans. J Nutr 1986;141:1–7.

    Google Scholar 

  35. Ito H, Kotake T, Masai M. In vitro degradation of oxalic acid by human faeces. Int J Urol 1996;3:207–211.

    Article  CAS  PubMed  Google Scholar 

  36. Hokama S, Honma Y, Toma C, Ogawa Y. Oxalate-degrading Enterococcus faecalis. Micro-biol Immunol 2000;44:235–240.

    CAS  Google Scholar 

  37. Campieri C, Campieri M, Bertuzzi V, Swennen E, Matteuzzi D, Stefoni S, Pirovano F, Centi C, Ulisse S, Famularo G, De Simone C. Reduction of oxaluria after an oral course of lactic acid bacteria at high concentration. Kidney Intern 2001;60:1097–1105.

    Article  CAS  Google Scholar 

  38. Allison MJ, Cook HM, Milne DB, Gallagher S, Clayman RV. Oxalate degradation by gastrointestinal bacteria from humans. J Nutr 1986;116:455–460.

    CAS  PubMed  Google Scholar 

  39. Dawson KA, Allison MJ, Hartman PA. Isolation and some characteristics of anaerobic oxalate-degrading bacteria from the rumen. Appl Environ Microbiol 1980;40:833–839.

    CAS  PubMed  Google Scholar 

  40. Duncan SH, Richardson AJ, Kaul P, Holmes RP, Allison MJ, Stewart CS. Oxalobacter formigenes and its potential role in human health. Appl Environ Microbiol 2002;68: 3841–3847.

    Article  CAS  PubMed  Google Scholar 

  41. Sidhu H, Allison MJ, Chow JM, Clark A, Peck AB. Rapid reversal of hyperoxaluria in a rat model after probiotic administration of Oxalobacter formigenes. J Urol 2001;166:1487–1491.

    Article  CAS  PubMed  Google Scholar 

  42. Belury MA. Inhibition of carcinogenesis by conjugated linoleic acid: potential mechanisms of action. J Nutr 2002;32:2995–2998.

    Google Scholar 

  43. Gaullier JM, Halse J, Hoye K, Kristiansen K, Fagertun H, Vik H, Gudmundsen O. Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans. Am J Clin Nutr 2004;79:1118–1125.

    CAS  PubMed  Google Scholar 

  44. Ip MM, Masso-Welch PA, Ip C. Prevention of mammary cancer with conjugated linoleic acid: role of the stroma and the epithelium. J Mammary Gland Biol Neoplasia 2003;8:103–118.

    Article  PubMed  Google Scholar 

  45. KN, Kritchevsky D, Pariza MW. Conjugated linoleic acid and atherosclerosis in rabbits. Atherosclerosis 1994;108:19–25.

    Article  CAS  PubMed  Google Scholar 

  46. Terpstra AH. Effect of conjugated linoleic acid on body composition and plasma lipids in humans: an overview of the literature. Am J Clin Nutr 2004;79:352–361.

    CAS  PubMed  Google Scholar 

  47. Wahle KW, Heys SD, Rotondo D. Conjugated linoleic acids: are they beneficial or detrimental to health? Prog Lipid Res 2004;43:553–587.

    Article  CAS  PubMed  Google Scholar 

  48. Alonso L, Cuesta EP, Gilliland SE. Production of free conjugated linoleic acid by Lactoba-cillus acidophilus and Lactobacillus casei of human intestinal origin. J Dairy Sci 2003;86:1941–1946.

    Article  CAS  PubMed  Google Scholar 

  49. Coakley M, Ross RP, Nordgren M, Fitzgerald G, Devery R, Stanton C. Conjugated linoleic acid biosynthesis by human-derived Bifidobacterium species. J Appl Microbiol 2003;94: 138–145.

    Article  CAS  PubMed  Google Scholar 

  50. Kishino S, Ogawa J, Omura Y, Matsumura K, Shimizu S. Conjugated linoleic acid production from linoleic acid by lactic acid bacteria. J Am Oil Chem Soc 2002;79:159–163.

    Article  CAS  Google Scholar 

  51. Rosberg-Cody E, Ross RP, Hussey S, Ryan CA, Murphy BP, Fitzgerald GF, Devery R, Stanton C. Mining the microbiota of the neonatal gastrointestinal tract for conjugated linoleic acid-producing bifidobacteria. Appl Environ Microbiol 2004;70:4635–4641.

    Article  CAS  Google Scholar 

  52. Smith EA, Macfarlane GT. Formation of phenolic and indolic compounds by ananerobic bacteria in the human large intestine. Microb Ecol 1997;33:180–188.

    Article  CAS  PubMed  Google Scholar 

  53. Cummings JH, Macfarlane GT. The control and consequences of bacterial fermentation in the human colon. J Appl Bacteriol 1991;70:443–459.

    CAS  PubMed  Google Scholar 

  54. O'Mahony L. Immunology of the small intestine. In: Intestinal Failure: Diagnosis, Management and Transplantation. Blackwell, Oxford, 2008.

    Google Scholar 

  55. Macpherson AJ, Harris N. Interactions between commensal intestinal bacteria and the immune system. Nat Rev Immunol 2004;4:478–485.

    Article  CAS  PubMed  Google Scholar 

  56. McCarthy J, O'Mahony L, O'Callaghan L, Shiel B, Vaughan EE, Fitzsimons N, Fitzgibbon J, O'Sullivan GC, Kiely B, Collins JK, Shanahan F, Double blind, placebo controlled trial of two probiotic strains in interleukin 10 knockout mice and mechanistic link with cytokine balance. Gut 2003;52:975–980.

    Article  CAS  PubMed  Google Scholar 

  57. O'Mahony L, O'Callaghan L, McCarthy J, Shilling D, Scully P, Sibartie S, Kavanagh E, Kirwan WO, Redmond HP, Collins JK, Shanahan F. Differential cytokine response from dendritic cells to commensal and pathogenic bacteria in different lymphoid compartments in humans. Am J Physiol Gastrointest Liver Physiol 2006;290:839–845.

    Article  CAS  Google Scholar 

  58. Belkaid Y, Rouse BT. Natural regulatory T cells in infectious disease. Nat Immunol 2005;6 (4):353–360.

    Article  CAS  PubMed  Google Scholar 

  59. Karim M, Kingsley CI, Bushell AR, Sawitzki BS, Wood KJ. Alloantigen-induced CD25– CD4– regulatory T cells can develop in vivo from CD25–CD4– precursors in a thymus-independent process. J Immunol 2004;172:923.

    CAS  PubMed  Google Scholar 

  60. Chen W, Jin W, Hardegen N, Lei KJ, Li L, Marinos N, McGrady G, Wahl SM. Conversion of peripheral CD4–CD25– naive T cells to CD4–CD25– regulatory T cells by TGF- induction of transcription factor Foxp3. J Exp Med 2003;198:1875.

    Article  CAS  PubMed  Google Scholar 

  61. Di Giacinto C, Marinaro M, Sanchez M, Strober W, Boirivant M. Probiotics ameliorate recurrent Th1-mediated murine colitis by inducing IL-10 and IL-10-dependent TGF-b bearing regulatory cells. J Immunol 2005;174:3237–3246.

    PubMed  Google Scholar 

  62. Shanahan F. Probiotics in inflammatory bowel disease — therapeutic rationale and role. Adv Drug Deliv Rev 2004;56:809–818.

    Article  CAS  PubMed  Google Scholar 

  63. O'Mahony L, McCarthy J, Kelly P, Hurley G, Luo F, Chen K, O'Sullivan GC, Kiely B, Collins JK, Shanahan F, Quigley EM. Lactobacillus and Bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles. Gastroenterology 2005;128:541–551.

    Article  PubMed  Google Scholar 

  64. Dinan TG, Quigley EM, Ahmed SM, Scully P, O'Brien S, O'Mahony L, O'Mahony S, Shanahan F, Keeling PW. Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential biomarker? Gastroenterology 2006;130(2): 304–311.

    Article  CAS  PubMed  Google Scholar 

  65. Duchmann R, Kaiser I, Hermann E, Mayet W, Ewe K, Meyer zum Buschenfelde KH. Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD). Clin Exp Immunol 1995;102:448–455.

    Article  CAS  PubMed  Google Scholar 

  66. Sudo N, Sawamura S, Tanaka K, Aiba Y, Kubo C, Koga Y. The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. J Immunol 1997;159:1739–1745.

    CAS  PubMed  Google Scholar 

  67. Mountzouris KC, McCartney AL, Gibson GR. Intestinal microflora of human infants and current trends for its nutritional modulation. Br J Nutr 2002;87:405–420.

    CAS  PubMed  Google Scholar 

  68. Fanaro S, Chierici R, Guerrini P, Vigi V. Intestinal microflora in early infancy: composition and development. Acta Paediatr Suppl 2003;91:48–55.

    CAS  PubMed  Google Scholar 

  69. Mackie RI, Sghir A, Gaskins HR. Developmental microbial ecology of the neonatal gastrointestinal tract. Am J Clin Nutr 1999;69:1035S–1045S.

    CAS  PubMed  Google Scholar 

  70. Vaughan EE, de Vries MC, Zoetendal EG, Ben-Amor K, Akkermans AD, de Vos WM. The intestinal LABs. Antonie Van Leeuwenhoek 2002;82:341–352.

    Article  CAS  PubMed  Google Scholar 

  71. Favier CF, Vaughan EE, De Vos WM, Akkermans AD. Molecular monitoring of succession of bacterial communities in human neonates. Appl Environ Microbiol 2002;68:219–226.

    Article  CAS  PubMed  Google Scholar 

  72. Boehm G, Stahl B, Jelinek J, Knol J, Miniello V, Moro GE. Prebiotic carbohydrates in human milk and formulas. Acta Paediatr Suppl 2005;94:18–21.

    Article  PubMed  Google Scholar 

  73. Coppa GV, Bruni S, Morelli L, Soldi S, Gabrielli O. The first prebiotics in humans: human milk oligosaccharides. J Clin Gastroenterol 2004;38:S80–S83.

    Article  CAS  PubMed  Google Scholar 

  74. Morrow AL, Ruiz-Palacios GM, Jiang X, Newburg DS. Human-milk glycans that inhibit pathogen binding protect breast-feeding infants against infectious diarrhea. J Nutr 2005;135:1304–1307.

    CAS  PubMed  Google Scholar 

  75. Gibson GR, Roberfroid MB. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr 1995;125:1401–1412.

    CAS  PubMed  Google Scholar 

  76. Andersson Y, Lindquist S, Lagerqvist C, Hernell O. Lactoferrin is responsible for the fungistatic effect of human milk. Early Hum Dev 2000;59:95–105.

    Article  CAS  PubMed  Google Scholar 

  77. Baldi A, Ioannis P, Chiara P, Eleonora F, Roubini C, Vittorio D. Biological effects of milk proteins and their peptides with emphasis on those related to the gastrointestinal ecosystem. J Dairy Res 2005;72:66–72.

    Article  CAS  PubMed  Google Scholar 

  78. Kimura K, McCartney AL, McConnell MA, Tannock GW. Analysis of fecal populations of bifidobacteria and lactobacilli and investigation of the immunological responses of their human hosts to the predominant strains. Appl Environ Microbiol 1997;63:3394–3398.

    CAS  PubMed  Google Scholar 

  79. Hooper LV, Midtvedt T, Gordon JI. How host-microbial interactions shape the nutrient environment of the mammalian intestine. Annu Rev Nutr 2002;22:283–307.

    Article  CAS  PubMed  Google Scholar 

  80. Boehm G, Jelinek J, Stahl B, van Laere K, Knol J, Fanaro S, Moro G, Vigi V. Prebiotics in infant formulas. J Clin Gastroenterol 2004;38:S76–S79.

    Article  CAS  PubMed  Google Scholar 

  81. Bennet R, Nord CE, Zetterstrom R. Transient colonization of the gut of newborn infants by orally administered bifidobacteria and lactobacilli. Acta Paediatr 1992;81:784–787.

    Article  CAS  PubMed  Google Scholar 

  82. Allen SJ, Okoko B, Martinez E, Gregorio G, Dans LF. Probiotics for treating infectious diarrhoea. Cochrane Database Syst Rev 2004;CD003048.

    Google Scholar 

  83. Bin-Nun A, Bromiker R, Wilschanski M, Kaplan M, Rudensky B, Caplan M, Hammerman C. Oral probiotics prevent necrotizing enterocolitis in very low birth weight neonates. J Pediatr 2005;147:192–196.

    Article  Google Scholar 

  84. Schaub B, Lauener R, von Mutius E. The many faces of the hygiene hypothesis. J Allergy Clin Immunol 2006;117:969–977; quiz 978.

    Article  PubMed  Google Scholar 

  85. Kirjavainen PV, Arvola T, Salminen SJ, Isolauri E. Aberrant composition of gut microbiota of allergic infants: a target of bifidobacterial therapy at weaning? Gut 2002;51:51–55.

    Article  CAS  PubMed  Google Scholar 

  86. Ouwehand AC, Isolauri E, He F, Hashimoto H, Benno Y, Salminen S. Differences in Bifidobacterium flora composition in allergic and healthy infants. J Allergy Clin Immunol 2001;108:144–145.

    Article  CAS  PubMed  Google Scholar 

  87. Viljanen M, Savilahti E, Haahtela T, Juntunen-Backman K, Korpela R, Poussa T, Tuure T, Kuitunen M. Probiotics in the treatment of atopic eczema/dermatitis syndrome in infants: a double-blind placebo-controlled trial. Allergy 2005;60:494–500.

    Article  CAS  PubMed  Google Scholar 

  88. Kalliomaki M, Salminen S, Poussa T, Isolauri E. Probiotics during the first 7 years of life: a cumulative risk reduction of eczema in a randomized, placebo-controlled trial. J Allergy Clin Immunol 2007;119:1019–1021.

    Article  PubMed  Google Scholar 

  89. McMurdo ME. A healthy old age: realistic or futile goal? Br Med J 2000;321:1149–1151.

    Article  CAS  Google Scholar 

  90. Harmsen HJM, Raangs GC, Franks AH, Wilderboer-Veloo CM, Welling GW. The effect of prebiotic inulin and the probiotic Bifidobacterium longum in the faecal microflora of healthy volunteers measured by FISH and DGGE. Microbiol Ecol Health Dis 2002;14:211–219.

    Article  CAS  Google Scholar 

  91. Vanhoutte T, Huys G, De Brandt E, Swings J. Temporal stability analysis of the microbiota in human faeces by denaturing gradient gel electrophoresis using universal and group-specific 16S rRNA gene primers. FEMS Microbiol Ecol 2004;48:437–446.

    Article  CAS  PubMed  Google Scholar 

  92. Zoetendal EG, Akkermans AD, De Vos WM. Temperature gradient gel electrophoresis analysis of 16S rRNA from human faecal samples reveals stable and host-specific communities of active bacteria. Appl Environ Microbiol 1998;64:3854–3859.

    CAS  PubMed  Google Scholar 

  93. Blaut M, Collins MD, Welling GW, Dore J, van Loo J, de Vos W. Molecular biological methods for studying the gut microbiota: the EU human gut flora project. Br J Nutr 2002;87: S203–S211.

    Article  CAS  PubMed  Google Scholar 

  94. Gavini F, Cayuela C, Antoine JM, Lecoq C, Lefebvre B, Membre JM. Differences in the spatial distribution of bifidobacterial and enterobacterial species in human faecal microflora of three different (children, adults, elderly) age groups. Microb Ecol Health Dis 2001;13:40– 45.

    Article  Google Scholar 

  95. He FA, Ouwehand AC, Isolauri E, Hosoda M, Benno Y, Salminen S. Differences in composition and mucosal adhesion of Bifidobacteria isolated from healthy adults and healthy seniors. Curr Microbiol 2001;43:351–354.

    Article  CAS  PubMed  Google Scholar 

  96. Woodmansey EJ, McMurdo MET, Macfarlane GT, Macfarlane S. Comparison of composi tions and metabolic activities of faecal microbiota in young adults and in antibiotic-treated and non-antibiotic treated elderly subjects. Appl Environ Microbiol 2004;70:6113–6122.

    Article  CAS  PubMed  Google Scholar 

  97. Walls AWG, Steele JG. The relationship between oral health and nutrition in older people. Mech Ageing Dev 2004;125:853–857.

    Article  CAS  PubMed  Google Scholar 

  98. Bitar KN, Patil SB. Aging and gastrointestinal smooth muscle. Mech Ageing Dev 2004; 125:907–910.

    Article  CAS  PubMed  Google Scholar 

  99. Saffrey MJ. Ageing of the enteric nervous system. Mech Ageing Dev 2004;125:899–906.

    Article  CAS  PubMed  Google Scholar 

  100. Hogenauer C, Hammer HF, Krejs GJ, Reisinger EC. Mechanisms and management of antibiotic-associated diarrhoea. Clin Infect Dis 1998;27:702–710.

    Article  CAS  PubMed  Google Scholar 

  101. Mylonakis E, Ryan ET, Claderwood SB. Clostridium difficile-associated diarrhoea. Arch Intern Med 2001;161:525–533.

    Article  CAS  PubMed  Google Scholar 

  102. Ljungberg B, Nilsson-Ehle I, Edlund C, Nord CE. Influence of ciprofloxacin on the colonic microflora in young and elderly volunteers: no impact of the altered drug absorption. Scand J Infect Dis 1990;22:205–208.

    Article  CAS  PubMed  Google Scholar 

  103. George RH, Symonds JM, Dimock F, Brown JD, Arabi Y, Shinagawa N, Keighley MR, Alexander-Williams J, Burdon DW. Identification of Clostridium difficile as a cause of pseudomembranous colitis. Br Med J 1978;1:695.

    Article  CAS  PubMed  Google Scholar 

  104. Hall IC, O'Toole E. Intestinal flora in new-born infants with a description of a new pathogenic anaerobe, Bacillus difficilis. Am J Dis Child 1935;49:390–402.

    Google Scholar 

  105. Al-Eidan FA, McElnay JC, Scott MG, Kearney MP. Clostridium difficile-associated diar rhoea in hospitalised patients. J Clin Pharm Ther 2000;25:101–109.

    Article  CAS  PubMed  Google Scholar 

  106. Cunningham R, Dale B, undy B, Gaunt N. Proton pump inhibitors as a risk factor for Clostridium difficile diarrhoea. J Hosp Infect 2003;54:243–245.

    Article  CAS  PubMed  Google Scholar 

  107. Forestier C, De Champs C, Vatoux C, Joly B. Probiotic activities of Lactobacillus casei rhamnosus: in vitro adherence to intestinal cells and antimicrobial properties. Res Microbiol 2001;152:167–173.

    Article  CAS  PubMed  Google Scholar 

  108. Roffe C. Biotherapy for antibiotic-associated and other diarrhoeas. J Infect 1996;32:1–10.

    Article  CAS  PubMed  Google Scholar 

  109. Tvede M, Rask-Madsen J. Bacteriotherapy for chronic relapsing Clostridium difficile diar rhoea in six patients. Lancet 1989;I:1156–1160.

    Article  Google Scholar 

  110. McFarland LV. Meta-analysis of probiotics for the prevention of antibiotic associated diarrhoea and the treatment of Clostridium difficile disease. Am J Gastroenterol 2006;101:812–822.

    Article  PubMed  Google Scholar 

  111. Bartosch S, Woodmansey EJ, Paterson JCM, McMurdo MET, Macfarlane GT. Microbiolo gical effects of consuming a symbiotic containing Bifidobacterium bifidum, Bifidobacterium lactis, and oligofructose in elderly persons, determined by real-time polymerase chain reaction and counting of viable bacteria. Clin Infect Dis 2005;40:28–37.

    Article  PubMed  Google Scholar 

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Murphy, E., Murphy, C., O'Mahony, L. (2009). Influence of the Gut Microbiota with Ageing. In: Percival, S.L. (eds) Microbiology and Aging. Humana Press. https://doi.org/10.1007/978-1-59745-327-1_8

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