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MiRNA Biogenesis and Regulation of Diseases: An Overview

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MicroRNA Profiling

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1509))

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Abstract

MicroRNAs (miRNAs) are small RNA molecules, with their role in gene silencing and translational repression by binding to target mRNAs. Since it was discovered in 1993, miRNA are found in all eukaryotic cells conserved across the species. In recent years, regulation of miRNAs are extensively studied for their role in biological processes as well as in development and progression of various human diseases including retinal disorder, neurodegenerative diseases, cardiovascular disease and cancer. This chapter summarises miRNA biogenesis and explores their potential roles in a variety of diseases. miRNAs holds huge potential for diagnostic and prognostic biomarkers, and as predictors of drug response.

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Authors and Affiliations

  1. SEQOME Ltd, Waterford, Ireland

    Anchal Vishnoi

  2. Department of Science, Waterford Institute of Technology, Main Campus Cork Road, Waterford, Ireland

    Sweta Rani

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  1. Anchal Vishnoi
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  2. Sweta Rani
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Correspondence to Sweta Rani .

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  1. Department of Science, Waterford Institute of Technology, Waterford, Ireland

    Sweta Rani

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Vishnoi, A., Rani, S. (2017). MiRNA Biogenesis and Regulation of Diseases: An Overview. In: Rani, S. (eds) MicroRNA Profiling. Methods in Molecular Biology, vol 1509. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6524-3_1

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  • DOI: https://doi.org/10.1007/978-1-4939-6524-3_1

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-6522-9

  • Online ISBN: 978-1-4939-6524-3

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