Definition
The infinitesimal phase response curve (iPRC) is a measure of an oscillator, which specifies how the phase of that oscillator shifts, as a function of the phase of a perturbation as the width and height of the pulse go to zero, approximating a continuous time delta function (see “Weak Coupling Theory”). In neurons, the iPRC measures the spike time shift in response to the injection of a small current (or less often a conductance) pulse at a given time. The iPRC should scale linearly with pulse area.
Detailed Description
The iPRC of neurons is of interest for several reasons. First, by using the iPRC, a prediction can be made about the synchronizing properties of synaptically coupled neurons. Given small conduction delays and weak coupling between neurons, nonnegative PRCs (type I PRCs or monophasic PRCs; see “Phase Response Curve, Measurement and Shape of General”) typically lead to synchronization between neurons only if they are coupled via inhibitory connections. In...
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References
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Further Reading
Ermentrout B, Terman DH (2010) Mathematical foundations of neuroscience. Springer, New York
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Stiefel, K. (2014). Phase Resetting, Measurement of Infinitessimal. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_267-1
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DOI: https://doi.org/10.1007/978-1-4614-7320-6_267-1
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