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Complexity of Comparing Hidden Markov Models

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Algorithms and Computation (ISAAC 2001)

Part of the book series: Lecture Notes in Computer Science ((LNCS,volume 2223))

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Abstract

The basic theory of hidden Markov models was developed and applied to problems in speech recognition in the late 1960’s, and has since then been applied to numerous problems, e.g. biological sequence analysis. In this paper we consider the problem of computing the most likely string generated by a given model, and its implications on the complexity of comparing hidden Markov models. We show that computing the most likely string, and approximating its probability within any constant factor, is NP-hard, and establish the NP-hardness of comparing two hidden Markov models under the Lα- and L 1-norms. We discuss the applicability of the technique used to other measures of distance between probability distributions. In particular we show that it cannot be used to prove NP-hardness of determining the Kullback-Leibler distance between the probability distributions of two hidden Markov models, or of comparing them under the L k -norm for any xed even integer k.

Supported by grants from Carlsbergfondet and the Prog. in Math. and Mol. Biology

Partially supported by the IST Programme of the EU under contract number IST-1999-14186 (ALCOM-FT)

funded by the University of Aarhus Research Foundation

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References

  1. N. Abe and M. K. Warmuth. On the computational complexity of approximating distributions by probabilistic automata. Machine Learning, 9:205–260, 1992.

    MATH  Google Scholar 

  2. K. Asai, S. Hayamizu, and K. Handa. Prediction of protein secondary structure by the hidden markov model. Comp. Appl. in the Biosciences, 9:141–146, 1993.

    Google Scholar 

  3. A. Bateman, E. Birney, R. Durbin, S. R. Eddy, K. L. Howe, and E. L. L. Sonnhammer. The Pfam protein families database. Nucleic Acid Research, 28:263–266, 2000.

    Article  Google Scholar 

  4. T. Batu, L. Fortnow, R. Rubinfeld, W. D. Smith, and P. White. Testing that distributions are close. In Proc. 15th STOC, pages 259–269, 2000.

    Google Scholar 

  5. G. A. Churchill. Stochastic models for heterogeneous DNA sequences. Bull. Math. Biol., 51:79–94, 1989.

    Article  MathSciNet  MATH  Google Scholar 

  6. T. M. Cover and J. A. Thomas. Elements of Information Theory. John Wiley & Sons, New York, 1991.

    Book  MATH  Google Scholar 

  7. L. Engebretsen and J. Holmerin. Clique is hard to approximate within n(1-o(1)). In Proc. 27th ICALP, volume 1853 of Lecture Notes in Computer Science, pages 2–12, 2000.

    MATH  Google Scholar 

  8. J. Feigenbaum, S. Kannan, M. Strauss, and M. Viswanathan. An approximate l 1-difference algorithm for massive data streams. In Proc. 40th FOCS, pages 501–511, 1999.

    Google Scholar 

  9. J. Fong and M. Strauss. An approximate l p-difference algorithm for massive data streams. In Proc. 17th STACS, 2000.

    Google Scholar 

  10. J. Håstad. Clique is hard to approximate within n 1-∈. Acta Mathematica, 182:105–142, 1999.

    Article  MathSciNet  Google Scholar 

  11. A. Krogh. Two methods for improving performance of an HMM and their application for gene nding. In Proc. 5th ISMB, pages 179–186, 1997.

    Google Scholar 

  12. A. Krogh, M. Brown, I. S. Mian, K. Sjölander, and D. Haussler. Hidden markov models in computational biology: Applications to protein modeling. Jour. Mol. Biol, 235:1501–1531, 1994.

    Article  Google Scholar 

  13. R. B. Lyngsø, C. N. S. Pedersen, and H. Nielsen. Metrics and similarity measures for hidden Markov models. In Proc. 7th ISMB, pages 178–186, 1999.

    Google Scholar 

  14. L. R. Rabiner. A tutorial on hidden markov models and selected applications in speech recognition. In Proc. of the IEEE, volume 77, pages 257–286, 1989.

    Google Scholar 

  15. Y. Singer and M. K. Warmuth. Training algorithms for hidden Markov models using entropy based distance functions. In Proc. 9th NIPS, pages 641–647, 1996.

    Google Scholar 

  16. E. L. L. Sonnhammer, G. von Heijne, and A. Krogh. A hidden Markov model for predicting transmembrane helices in protein sequences. In Proc. 6th ISMB, 1998.

    Google Scholar 

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Lyngsø, R.B., Pedersen, C.N.S. (2001). Complexity of Comparing Hidden Markov Models. In: Eades, P., Takaoka, T. (eds) Algorithms and Computation. ISAAC 2001. Lecture Notes in Computer Science, vol 2223. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-45678-3_36

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  • DOI: https://doi.org/10.1007/3-540-45678-3_36

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-42985-2

  • Online ISBN: 978-3-540-45678-0

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